Functional imaging of cortico-limbic predictors of emotion regulation, emotion reactivity, and risk for suicidal ideation and behavior

情绪调节、情绪反应性以及自杀意念和行为风险的皮质边缘预测因子的功能成像

• 批准号: 10171911
• 负责人: Michael F Armey
• 金额: $ 51.62万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-09 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10171911
• 关键词: Age; Amygdaloid structure; Anger; Anterior; Applications Grants; Behavior; C10; Characteristics; Cognition; Communities; Computers; Corpus striatum structure; Coupled; Data; Ecological momentary assessment; Elements; Emotional; Emotions; Enrollment; Event; Feeling suicidal; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Gender; Genetic; Goals; Hippocampus (Brain); Hospitalization; Hyperactivity; Individual; Inpatients; Intervention; Investments; Laboratories; MRI Scans; Magnetic Resonance Imaging; Measures; Medial; Meta-Analysis; Modeling; Monitor; National Institute of Mental Health; Participant; Patients; Prefrontal Cortex; Process; Psychiatric Diagnosis; Psychophysiology; Public Health; Regulation; Research; Resolution; Rest; Risk Factors; Sampling; Structure; Suicide; Suicide attempt; Suicide prevention; Symptoms; Thalamic structure; United States; Universities; Work; base; brain behavior; cingulate cortex; completed suicide; emotion regulation; emotional experience; endophenotype; executive function; experience; follow-up; gray matter; heart rate variability; information processing; interest; morphometry; multimodality; neural circuit; neuroimaging; novel; prisma; response; stress reactivity; suicidal; suicidal behavior; suicidal morbidity; suicidal risk; suicide rate

Project Summary/Abstract Suicide rates are on the rise, and recent investments in treatment and intervention have done little to turn the tide. While studies have identified cross-sectional predictors of suicidal ideation and behavior (e.g. age, gender, psychiatric diagnosis), the processes that underpin episodic suicide risk – that is, episodes of suicidal ideation and behavior as they occur in the real world – remain poorly understood. Neuroimaging studies examining structural and functional alterations present in individuals with suicidal ideation (SI) and behavior (SB) have implicated elements of a fronto-striato-amygdala circuit underlying executive control and emotion processing as conferring suicide risk. This circuit involves key regions of interest (ROIs) including the dorsolateral prefrontal cortex (dlPFC), ventral medial PFC (vmPFC)/orbitofrontal cortex (OFC), and projections to the thalamus, amygdala, hippocampus, caudate, and frontotemporal-striatum. This neural circuit may moderate emotional response through an opponent process model of reactivity to, and regulation of, emotional experiences. Specifically, initial reactivity to emotion involves bottom-up information processing from sensorimotor inputs to the amygdala and, ultimately, to the anterior cingulate cortex (ACC) and associated ROIs. Conversely, regulation of emotional experiences involves top-down information processing, effortful control, higher cognition, and executive functioning, originating in the PFC and associated ROIs. Our team (1R01MH095786), is developing an emotion reactivity translational endophenotype for suicide integrating genetics, psychophysiological monitoring coupled to an emotion reactivity task (i.e. Paced Audio Serial Addition Task), and real-world symptom and experiential sampling via ecological momentary assessment (EMA). Preliminary findings suggest that participants who have made a suicide attempt (SA) show greater anger reactivity during the most stressful part of the PASAT as compared to participants with SI; this response may represent a novel emotion reactivity marker of suicide risk. We believe that an important next step in understanding emotion reactivity in suicide is to examine the fronto-striato-amygdala top-down/bottom-up information-processing model using functional neuroimaging in association with laboratory-based and real-world measures (i.e. ecological momentary assessment) of emotion reactivity and regulation.

项目摘要/摘要 自杀率正在上升，最近在治疗和干预方面的投资对扭转 潮汐。虽然研究已经确定了自杀意念和行为的横断面预测因素(例如年龄、性别、 精神病诊断)，即支持间歇性自杀风险的过程 以及在现实世界中发生的行为-仍然鲜为人知。神经影像研究检查 有自杀意念(SI)和行为(SB)的个体存在结构和功能改变 作为执行控制和情绪处理基础的额叶-纹状体-杏仁核回路的牵连成分 有自杀风险。该环路涉及关键感兴趣区(ROI)，包括前额背外侧 大脑皮质(DlPFC)、腹侧PFC(VmPFC)/眶前叶皮质(OFC)和丘脑的投射， 杏仁核、海马体、尾状核和额颞纹状体。这种神经回路可能会缓和情绪 通过对情绪体验的反应和调节的对手过程模型作出反应。 具体地说，对情绪的初始反应涉及自下而上的信息处理，从感觉运动输入到 杏仁核，并最终到达前扣带皮质(ACC)和相关的ROI。相反， 情绪体验的调节涉及自上而下的信息处理，努力控制，更高 认知和执行功能，起源于PFC和相关的ROI。我们的团队(1R01MH095786)， 正在开发一种结合遗传学的自杀情绪反应性翻译内表型， 与情绪反应性任务(即，步调音频序列添加任务)相耦合的心理生理监测， 以及通过生态瞬时评估(EMA)进行的真实症状和经验采样。初步 研究结果表明，有过自杀企图(SA)的参与者在 与SI参与者相比，PASAT中压力最大的部分；这种反应可能代表了一种新的 自杀风险的情绪反应标记物。我们认为，理解情绪的下一步重要步骤 自杀的反应性是检查额纹状体杏仁核自上而下/自下而上的信息处理 使用功能神经成像并结合基于实验室和真实世界的测量(即 情绪反应和调节的生态瞬时评估)。

项目成果

Validation of an emotional stop-signal task to probe individual differences in emotional response inhibition: Relationships with positive and negative urgency.

• DOI: 10.1177/23982128211058269
• 发表时间: 2021-01
• 期刊: Brain and neuroscience advances
• 作者: Allen KJD;Johnson SL;Burke TA;Sammon MM;Wu C;Kramer MA;Wu J;Schatten HT;Armey MF;Hooley JM
• 通讯作者: Hooley JM

Characteristics of suicide attempts associated with lethality and method: A latent class analysis of the Military Suicide Research Consortium.

与致死率和方法相关的自杀未遂特征：军事自杀研究联盟的潜在类别分析。

• DOI: 10.1016/j.jpsychires.2022.02.016
• 发表时间: 2022
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Gromatsky,Molly;Edwards,EmilyR;Sullivan,SarahR;vanLissa,CasparJ;Lane,Robert;Spears,AngelaPage;Mitchell,EmilyL;Armey,MichaelF;Cáceda,Ricardo;Goodman,Marianne
• 通讯作者: Goodman,Marianne