A Transdiagnostic Assessment of Electroconvulsive Therapy Modulation of Anhedonia and Reward circuitry: Targets, Biomarkers and Predictors of Response
电惊厥治疗快感缺失和奖励回路调节的跨诊断评估:目标、生物标志物和反应预测因子
基本信息
- 批准号:10171912
- 负责人:
- 金额:$ 70.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-05 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:Amygdaloid structureAnatomyAnhedoniaAnisotropyAnteriorAntsAreaBehaviorBehavioralBilateralBiological MarkersBiologyBipolar DepressionBrainBrain imagingClinicalClinical TrialsDataDiagnosisDiffuseDimensionsDiseaseDorsalElectroconvulsive TherapyGeneralized seizuresGoalsHippocampus (Brain)HumanImageImaging technologyInferiorInferior frontal gyrusInsula of ReilLeadLearningLobuleMagnetic Resonance ImagingMajor Depressive DisorderMeasuresMedicineMethodologyMood DisordersMotivationNational Institute of Mental HealthNeurosciencesNucleus AccumbensParietalPathologicPathway interactionsPatientsPositive ValencePropertyProtocols documentationPsychiatryPsychological reinforcementRadialResearch Domain CriteriaRewardsSeveritiesStructureStructure of superior frontal gyrusSubcategorySymptomsSyndromeSystemTherapeuticTherapeutic Human ExperimentationTimeUnipolar DepressionVentral Tegmental Areabasebehavior measurementbiomarker performancecingulate cortexcohortconnectomedentate gyruseffective therapyexperienceimprovedinnovationmorphometrymultimodalityneuroimagingneuropsychiatric disorderneuroregulationnovelpleasurepredicting responseputamenresponsereward circuitryreward processingstemtargeted biomarkertherapeutic targettooltractographytranslational approach
项目摘要
Electroconvulsive Therapy (ECT) is the most effective treatment in psychiatry, and among the most
effective in medicine. Despite its apparent non-focal effects leading to a generalized seizure, its therapeutic
benefits are specific to a few clinical syndromes, including major depressive disorder (MDD) and bipolar
depression (BD). These two syndromes share core deficits in reward processing (i.e. anhedonia). ECT
improves anhedonia across mood disorders and syndromes, implying selective effects on the functional
dynamics and structural properties of reward networks.
Reward-related functions represent key behavioral dimensions of pathological relevance across
neuropsychiatric disorders, and have a central place as positive valence constructs in the RDoC matrix. There
has been a growing recognition that “anhedonia” does not represent a unitary dimension; among its
subcategories, three constructs emerge with clear relevance to behavior and disease: consummation (liking),
motivation (wanting) and reinforcement (learning). Quantitative behavioral measures exist for each of these
three, with clinical validity as biomarkers and predictors of response.
The anatomy of the reward network is well known, with a core in the ventral tegmental area (VTA) and
the Nucleus Accumbens (NAc), and projections to cortical and subcortical nodes via the mesocorticolimbic
pathway and its ramifications. The Human Connectome Project (HCP) has significantly advanced the
technologies for imaging brain connections in humans, accelerating innovation in the emerging field of
Connectomics. Preliminary data from our group describes the feasibility of obtaining multimodal MRI measures
of reward circuit biology (morphometry, tractography, functional connectivity) in patients undergoing ECT, and
extracting clinically meaningful information to identify treatment targets and develop biomarkers and predictors.
At a time when therapeutic research is stalled due to the absence of clear targets and useful
biomarkers, understanding the mechanisms of our most effective treatments is a priority for our field. In this
study, we propose a novel translational strategy that takes advantage of the high efficacy and fast response of
ECT, and uses it to probe target engagement at the circuit level. With a systems neuroscience framework, in
line with NIMH strategic priorities and the RDoC Initiative, we will focus on reward circuitry and its clinical
dimensions across two clinical syndromes that are commonly treated with ECT: MDD and BD. We will use
HCP multimodal MRI protocols combined with validated behavioral measures of reward constructs to assess
patients before, during and after ECT, in addition to a cohort of matched healthy controls that will be imaged
twice. This study is innovative in its proposal to combine ECT with multimodal MRI as a framework to study
anhedonia transdiagnostically, with the translational aims to (1) discover treatment targets, (2) develop
biomarkers and (3) identify predictors of response.
电休克疗法(ECT)是最有效的精神病学治疗方法之一
项目成果
期刊论文数量(37)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Rapid whole-brain electric field mapping in transcranial magnetic stimulation using deep learning.
- DOI:10.1371/journal.pone.0254588
- 发表时间:2021
- 期刊:
- 影响因子:3.7
- 作者:Xu G;Rathi Y;Camprodon JA;Cao H;Ning L
- 通讯作者:Ning L
Individual response to electroconvulsive therapy is not correlated between multiple treatment courses.
- DOI:10.1016/j.jad.2021.11.002
- 发表时间:2022-02-01
- 期刊:
- 影响因子:6.6
- 作者:Hart KL;Henry ME;McCoy TH;Seiner SJ;Luccarelli J
- 通讯作者:Luccarelli J
Transcranial direct current stimulation of default mode network parietal nodes decreases negative mind-wandering about the past.
- DOI:10.1007/s10608-019-10044-9
- 发表时间:2020-02
- 期刊:
- 影响因子:2.8
- 作者:Chou T;Hooley JM;Camprodon JA
- 通讯作者:Camprodon JA
Changes in seizure duration during acute course electroconvulsive therapy.
- DOI:10.1016/j.brs.2021.05.016
- 发表时间:2021-07
- 期刊:
- 影响因子:7.7
- 作者:Luccarelli J;McCoy TH Jr;Seiner SJ;Henry ME
- 通讯作者:Henry ME
Transcranial Direct Current Stimulation to the Left Dorsolateral Prefrontal Cortex Improves Cognitive Control in Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Behavioral and Neurophysiological Study.
- DOI:10.1016/j.bpsc.2020.11.006
- 发表时间:2021-04
- 期刊:
- 影响因子:0
- 作者:Dubreuil-Vall L;Gomez-Bernal F;Villegas AC;Cirillo P;Surman C;Ruffini G;Widge AS;Camprodon JA
- 通讯作者:Camprodon JA
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Joan A Camprodon其他文献
Joan A Camprodon的其他文献
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{{ truncateString('Joan A Camprodon', 18)}}的其他基金
State-dependent modulation of interactions of theta and gamma rhythms in working memory
工作记忆中θ节律和伽马节律相互作用的状态依赖性调节
- 批准号:
10740352 - 财政年份:2023
- 资助金额:
$ 70.6万 - 项目类别:
Suicide Circuit Therapeutics: Engaging Novel Targets with Rapid and Individualized MRI-Guided Accelerated TMS
自杀回路治疗:通过快速、个性化的 MRI 引导加速 TMS 参与新靶点
- 批准号:
10646517 - 财政年份:2023
- 资助金额:
$ 70.6万 - 项目类别:
Individualized Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
阿尔茨海默病的个体化闭环神经调节疗法
- 批准号:
10510106 - 财政年份:2022
- 资助金额:
$ 70.6万 - 项目类别:
Individualized Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
阿尔茨海默病的个体化闭环神经调节疗法
- 批准号:
10680555 - 财政年份:2022
- 资助金额:
$ 70.6万 - 项目类别:
Personalized target selection for TMS therapy using functional vs. structural connectivity MRI
使用功能性与结构性连接 MRI 进行 TMS 治疗的个性化靶点选择
- 批准号:
9433834 - 财政年份:2017
- 资助金额:
$ 70.6万 - 项目类别:
A Transdiagnostic Assessment of Electroconvulsive Therapy Modulation of Anhedonia and Reward circuitry: Targets, Biomarkers and Predictors of Response
电惊厥治疗快感缺失和奖励回路调节的跨诊断评估:目标、生物标志物和反应预测因子
- 批准号:
9398707 - 财政年份:2017
- 资助金额:
$ 70.6万 - 项目类别:
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