Discipline C: Radiochemisty, Analytical Track 2: Capability/Capacity Development - Expansion Alpha

学科 C：放射化学、分析轨道 2：能力/能力发展 - 扩展 Alpha

• 批准号: 10176090
• 负责人: Dustin May
• 金额: $ 15万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10176090
• 关键词: Discipline; Radiochemisty; Analytical; Track; Capability

Project Summary/Abstract - Discipline C: Radiochemistry Analytical Track 2: Radiochemistry Capacity/Capability Development (Alpha Expansion) The State Hygienic Laboratory’s (SHL) participation in this project contributes to the overall objective of the grant by enhancing the capacity and capabilities of Iowa’s State Hygienic Laboratory (SHL) to respond to foodborne radiological threats as part of an integrated food safety system by expanding SHL’s ability to quickly screen a variety food products for alpha-emitting radionuclides. Given SHL’s current ability to quantitatively analyze for discrete alpha-emitters, this enhanced screening capacity will help SHL triage samples and expedite both qualitative and quantitative analysis of food products for alpha-emitting radionuclides in a radiological emergency. The specific aims of this project are to: 1. Purchase a microwave digestion system and additional gas-flow proportional counting detectors to enable the performance of the FERN-RAD.0003.00, Rapid dissolution of liquid organic matrices in preparation for gross alpha particle analysis. 2. Expand the list of foods to able to be analyzed at SHL by FERN-RAD.0003.00 via Level B validation studies on a variety of solid food products. 3. Train designated staff in the analysis of foods for gross alpha particles via FERN-RAD.003.00. 4. Demonstrate competency through a proficiency test offered by a suitable proficiency testing program, or if unavailable, a laboratory developed competency exercise. 5. Attend the annual LFFM Face-to-Face Meeting. In the first six months of the grant period SHL will procure, install, and optimize a microwave digestion system, and implement the FERN.0003.00 method. SHL will also complete training of staff on this method in the first six months of the grant period. In the last six months of the grant period, SHL will screen 25 juice for gross alpha particles and perform FERN Level B validation studies on five solid food types to increase SHL’s screening capacity. Successful completion of this project will help the FDA enhance its nationally integrated food safety system and will strengthen its efforts to detect, prevent, and minimize foodborne exposures. This project is also be beneficial to SHL by enhancing its sample preparation and analytical capacity and providing a training opportunity for staff in sample preparation techniques and method validations.

项目概要/摘要-学科C：放射化学 分析轨道2：放射化学能力/能力发展（Alpha扩展） 国家卫生实验室（SHL）对该项目的参与有助于实现 通过提高爱荷华州的国家卫生实验室（SHL）的能力和能力， 食源性放射性威胁作为综合食品安全系统的一部分，通过扩大SHL的能力， 对各种食品进行阿尔法放射性核素检测。鉴于SHL目前的能力， 分析离散的α-发射体，这种增强的筛选能力将有助于SHL分类样品， 加快对食品中的α放射性核素进行定性和定量分析， 辐射紧急情况 该项目的具体目标是： 1.购买微波消解系统和额外的气流比例计数检测器， 实现FERN-RAD.0003.00的性能，液体有机基质在 用于总α粒子分析的准备。 2.扩展食品列表，以便能够在SHL通过FERN-RAD.0003.00通过B级验证进行分析 研究各种固体食品。 3.通过FERN-RAD.003.00培训指定人员分析食品中的总α粒子。 4.通过适当的能力测试计划提供的能力测试证明能力， 或者，如果没有，则进行实验室开发的能力练习。 5.参加年度实况调查团面对面会议。 在赠款期的前六个月，SHL将采购、安装和优化微波消解系统， 并执行FERN.0003.00方法。SHL还将在第一年完成对员工的培训 六个月的补助期。在最后六个月的赠款期间，SHL将筛选25果汁毛 α粒子，并对五种固体食物进行FERN B级验证研究，以增加SHL 筛选能力。该项目的成功完成将有助于FDA提高其国家综合 欧盟将加强其食品安全体系，并将加强努力，以检测、预防和尽量减少食源性暴露。这 该项目也有利于SHL提高其样品制备和分析能力，并提供 为工作人员提供样品制备技术和方法验证培训机会。