Development of the first wireless near infrared spectroscopy device for preclinical monitoring of cerebral oxygenation
开发第一台用于临床前脑氧合监测的无线近红外光谱仪
基本信息
- 批准号:10174203
- 负责人:
- 金额:$ 5.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAnesthesia proceduresAnimal ModelAnimalsBehavioralBiomedical ResearchBiotechnologyBlood flowBrainBrain InfarctionBrain InjuriesBrain IschemiaCause of DeathCerebral InfarctionCerebral cortexCerebrovascular CirculationClinical TrialsDataDevelopmentDevicesEvaluationFailureFeedbackFiber OpticsFibrinolytic AgentsGoalsGoldHourImageImaging DeviceInfarctionIschemiaIschemic StrokeKnowledgeLaser-Doppler FlowmetryLettersLicensingLightLinear RegressionsLiquid substanceLocationLongitudinal StudiesMagnetic Resonance ImagingMeasurementMeasuresMedicalMiddle Cerebral Artery OcclusionModelingMonitorMusNear-Infrared SpectroscopyNeurologicNeuroprotective AgentsNoiseOpticsOryctolagus cuniculusOxyhemoglobinPenetrationPharmaceutical PreparationsPhasePre-Clinical ModelProceduresPropertyRattusReactionReperfusion TherapyResearchSecureSignal TransductionSkinSmall Business Innovation Research GrantSourceStrokeSystemTechnologyTestingTherapeuticTimeTissuesTranslationsTreatment EfficacyUnited StatesVisualizationWireless TechnologyWorkabsorptionbasecerebral oxygenationcostcost effectivedata acquisitiondeoxyhemoglobindisabilitydrug candidatefeature extractionimprovedin vivoinnovationinstrumentischemic injurymaleminiaturizeminimally invasivenon-invasive monitoroptical imagingpre-clinicalpreclinical efficacypreclinical studyprototypesensorstroke modeltechnological innovationtooluser-friendly
项目摘要
PROJECT SUMMARY
Stroke is the fifth largest cause of death and a leading cause of long-term disability among adults in the United
States. More than 300 neuroprotective and thrombolytic drug candidates for ischemic stroke have failed in
clinical trials between 1995 and 2015, raising concerns regarding the efficacy of preclinical studies. Our long-
term goal is to improve the value of animal models of ischemic stroke and accelerate the path of the most
efficacious treatments to clinical trials with reduced failure rates and associated costs. The goal of this SBIR
proposal is to demonstrate the utility of a wireless optical imaging instrument for providing an in vivo estimate
of brain ischemia. Such knowledge will reduce inconsistency in animal models of ischemic stroke and enable
longitudinal assessment of treatments’ efficacy.
At Barati Medical, LLC, we have developed a miniaturized, wireless near infrared spectroscopy (NIRS)
prototype for noninvasive monitoring of cerebral oxygenation parameters, i.e. deoxyhemoglobin (Hb) and
oxyhemoglobin (HbO2), in rats. In a preliminary study, our prototype detected a twofold reduction in cerebral
oxygenation during deep anesthesia relative to light anesthesia in a male rat. The product of this proposal will
be a cost-effective, miniaturized, wireless NIRS platform for the measurement of cerebral oxygenation in small
lab animals, which enables in vivo, longitudinal assessment of brain injury models and treatments’ efficacy.
Our innovation centers on the utility of a cost-effective NIRS solution in predicting the infarct volume after
procedures of middle cerebral artery occlusion (MCAO) in freely moving animals. No other in vivo measure is
readily available that accurately predicts infarct volume or behavioral deficit.
Our Specific Aims are to refine the NIRS prototype, demonstrate the feasibility of the NIRS device in predicting
behavioral deficits and infarct volume at 48h after ischemic stroke, and show the feasibility of continuous, long-
term measurement of cerebral oxygenation during the subacute phase of ischemic stroke in rats.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Near infrared spectroscopy detection of hemispheric cerebral ischemia following middle cerebral artery occlusion in rats.
近红外光谱检测大鼠大脑中动脉闭塞后半球脑缺血的情况
- DOI:10.1016/j.neuint.2022.105460
- 发表时间:2023
- 期刊:
- 影响因子:4.2
- 作者:Wong,Ardy;Bhuiyan,MohammadIqbalHossain;Rothman,Jeffrey;Drew,Kelly;Pourrezaei,Kambiz;Sun,Dandan;Barati,Zeinab
- 通讯作者:Barati,Zeinab
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