Development of the first wireless near infrared spectroscopy device for preclinical monitoring of cerebral oxygenation

开发第一台用于临床前脑氧合监测的无线近红外光谱仪

• 批准号: 10174203
• 负责人: Zeinab Barati
• 金额: $ 5.5万
• 依托单位: BARATI MEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10174203
• 关键词: Acute; Adult; Anesthesia procedures; Animal Model; Animals; Behavioral; Biomedical Research; Biotechnology; Blood flow; Brain; Brain Infarction; Brain Injuries; Brain Ischemia; Cause of Death; Cerebral Infarction; Cerebral cortex; Cerebrovascular Circulation; Clinical Trials; Data; Development; Devices; Evaluation; Failure; Feedback; Fiber Optics; Fibrinolytic Agents; Goals; Gold; Hour; Image; Imaging Device; Infarction; Ischemia; Ischemic Stroke; Knowledge; Laser-Doppler Flowmetry; Letters; Licensing; Light; Linear Regressions; Liquid substance; Location; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Medical; Middle Cerebral Artery Occlusion; Modeling; Monitor; Mus; Near-Infrared Spectroscopy; Neurologic; Neuroprotective Agents; Noise; Optics; Oryctolagus cuniculus; Oxyhemoglobin; Penetration; Pharmaceutical Preparations; Phase; Pre-Clinical Model; Procedures; Property; Rattus; Reaction; Reperfusion Therapy; Research; Secure; Signal Transduction; Skin; Small Business Innovation Research Grant; Source; Stroke; System; Technology; Testing; Therapeutic; Time; Tissues; Translations; Treatment Efficacy; United States; Visualization; Wireless Technology; Work; absorption; base; cerebral oxygenation; cost; cost effective; data acquisition; deoxyhemoglobin; disability; drug candidate; feature extraction; improved; in vivo; innovation; instrument; ischemic injury; male; miniaturize; minimally invasive; non-invasive monitor; optical imaging; pre-clinical; preclinical efficacy; preclinical study; prototype; sensor; stroke model; technological innovation; tool; user-friendly

PROJECT SUMMARY Stroke is the fifth largest cause of death and a leading cause of long-term disability among adults in the United States. More than 300 neuroprotective and thrombolytic drug candidates for ischemic stroke have failed in clinical trials between 1995 and 2015, raising concerns regarding the efficacy of preclinical studies. Our long- term goal is to improve the value of animal models of ischemic stroke and accelerate the path of the most efficacious treatments to clinical trials with reduced failure rates and associated costs. The goal of this SBIR proposal is to demonstrate the utility of a wireless optical imaging instrument for providing an in vivo estimate of brain ischemia. Such knowledge will reduce inconsistency in animal models of ischemic stroke and enable longitudinal assessment of treatments’ efficacy. At Barati Medical, LLC, we have developed a miniaturized, wireless near infrared spectroscopy (NIRS) prototype for noninvasive monitoring of cerebral oxygenation parameters, i.e. deoxyhemoglobin (Hb) and oxyhemoglobin (HbO2), in rats. In a preliminary study, our prototype detected a twofold reduction in cerebral oxygenation during deep anesthesia relative to light anesthesia in a male rat. The product of this proposal will be a cost-effective, miniaturized, wireless NIRS platform for the measurement of cerebral oxygenation in small lab animals, which enables in vivo, longitudinal assessment of brain injury models and treatments’ efficacy. Our innovation centers on the utility of a cost-effective NIRS solution in predicting the infarct volume after procedures of middle cerebral artery occlusion (MCAO) in freely moving animals. No other in vivo measure is readily available that accurately predicts infarct volume or behavioral deficit. Our Specific Aims are to refine the NIRS prototype, demonstrate the feasibility of the NIRS device in predicting behavioral deficits and infarct volume at 48h after ischemic stroke, and show the feasibility of continuous, long- term measurement of cerebral oxygenation during the subacute phase of ischemic stroke in rats.

项目总结

项目成果

Near infrared spectroscopy detection of hemispheric cerebral ischemia following middle cerebral artery occlusion in rats.

近红外光谱检测大鼠大脑中动脉闭塞后半球脑缺血的情况

• DOI: 10.1016/j.neuint.2022.105460
• 发表时间: 2023
• 期刊: Neurochemistry international
• 影响因子: 4.2
• 作者: Wong,Ardy;Bhuiyan,MohammadIqbalHossain;Rothman,Jeffrey;Drew,Kelly;Pourrezaei,Kambiz;Sun,Dandan;Barati,Zeinab
• 通讯作者: Barati,Zeinab