Diversity Supplement: Mechanistic Assessment of Blood Flow Restricted Training for an ACL Injury

多样性补充：ACL 损伤血流受限训练的机制评估

基本信息

批准号：
10175754
负责人：
Brian Noehren
金额：
$ 12.46万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-22 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10175754
关键词：
Address Affect Area Atrophic Automobile Driving Biological Biomechanics Blood flow Cell Nucleus Cell Respiration Cell model Clinical Clinical Trials Data Disadvantaged Dose Elderly Exposure to Faculty Fiber Fibrosis Funding Genetic Transcription Goals Human Imaging Techniques Impairment In Vitro Individual Injury Intake Intestines Kidney Knock-out Lead Learning Liver MADH3 gene Magnetic Resonance Imaging Measures Mediating Mitochondria Molecular Morphology Mus Muscle Muscle Cells Muscle Fibers Muscle Weakness Muscular Atrophy National Institute of Arthritis and Musculoskeletal and Skin Diseases Nutritionist Operative Surgical Procedures Outcome Parents Participant Pathway interactions Patients Persons Physical therapy Proteins Publishing Reconstructive Surgical Procedures Research Research Personnel Research Project Grants Respiration Risk Role Signal Transduction Skeletal Muscle Succinate Dehydrogenase Techniques Testing Time Tissues Training Transforming Growth Factor beta Vitamin D Vitamin D Deficiency Vitamin D supplementation Vitamin D3 Receptor Work anterior cruciate ligament injury anterior cruciate ligament reconstruction anterior cruciate ligament rupture experience improved innovation knee mechanics mRNA Expression member muscle strength new therapeutic target parent grant quadriceps muscle receptor binding receptor expression response skills treatment as usual vastus lateralis young adult

项目摘要

Abstract: Anterior cruciate ligament reconstruction surgery results in protracted quadriceps weakness that is associated with altered biomechanics and heightened risk of subsequent injuries. Little progress has been made in improving quadriceps strength in the past 15-20 years. Alterations in the morphological and cellular composition of the vastus lateralis muscle promote muscle weakness following an anterior cruciate ligament reconstruction. These features are not responsive to traditional physical therapy techniques. A promising emerging treatment, blood flow restriction training (BFRT) has been shown to address these same alterations in healthy subjects; however, it has never been tested in those with an injury. Pilot data in the current proposal shows that BFRT can lead to a significant increase in muscle strength following an anterior cruciate ligament injury. This project seeks to mechanistically determine the ability of BFRT to address underlying muscle cellular deficits following anterior cruciate ligament reconstruction compared to usual care. Goals in the current proposal are as follows: aim 1 will determine if BFRT is able to significantly improve knee mechanics and quadriceps strength following an anterior cruciate ligament reconstruction compared to usual care. Aim 2 will use advanced magnetic resonance imaging techniques to assess improvements in quadriceps morphology after training with BFRT. Lastly, aim 3 will identify BFRT-mediated improvements in cellular deficits in the quadriceps as the result of BFRT training versus usual care. The expected outcomes will show for the first time that BFRT is an effective mechanistic treatment for normalizing quadriceps strength within individuals following an anterior cruciate ligament reconstruction.

抽象的：前交叉韧带重建手术导致持久的股四头肌无力，与之相关随着生物力学的改变，随后受伤的风险增加。几乎没有进展在过去的15 - 20年中，提高股四头肌的强度。形态和细胞的改变股外侧肌肉的组成促进前交叉韧带后肌肉无力重建。这些特征对传统物理疗法技术没有反应。有希望的新兴治疗，血流限制训练（BFRT）已被证明可以解决这些相同的改变在健康的受试者中；但是，在受伤的人中从未对其进行测试。当前提案中的试点数据表明BFRT可能导致前交叉韧带后肌肉强度显着增加受伤。该项目试图从机械上确定BFRT解决潜在肌肉的能力与通常的护理相比，前交叉韧带重建后的细胞缺陷。目前的目标建议如下：AIM 1将确定BFRT是否能够显着改善膝盖力学和与通常的护理相比，前交叉韧带重建后的股四头肌强度。 AIM 2意志使用先进的磁共振成像技术来评估股四头肌形态的改进在接受BFRT训练之后。最后，AIM 3将确定BFRT介导的细胞缺陷改善股四头肌是BFRT培训与常规护理的结果。预期的结果将首次显示该BFRT是一种有效的机械处理，用于使股四头肌的强度正常化。前交叉韧带重建。