Developmental Mechanisms of Trachea-Esophageal Birth Defects

该方案包括三个综合项目，涉及两个机构，辛辛那提儿童医院医疗 中心(CCHMC)和哥伦比亚大学，包括多个部门和研究所。该计划 提出广泛而雄心勃勃的目标，包括招募气管食道分娩患者 缺陷用于表型和基因分型、出生缺陷的动物模型和人类组织生成。至 为了支持这些努力，我们提出了两个核心，集成基因组学核心和这个管理核心。这个 管理核心将在帮助协调并最终实现这些方面发挥几个重要作用 雄心勃勃的目标。重要的是，管理核心将允许主要调查人员专注于临床 以及这一计划的科学方面。行政核心将负责科学管理 以及协调、监测科学进步、人员管理、遵守法规 保证，方案内的沟通，在辛辛那提组织年度务虚会，金融 行政和预算监督，并帮助协调新试剂和模型系统的共享， 以及帮助在项目之间共享数据。

This program includes three integrated projects, across two institutions, Cincinnati Children’s Hospital Medical Center (CCHMC) and Columbia University and includes multiple divisions and institutes. The program proposes broad and ambitious aims that encompass recruitment of patients with tracheaesophageal birth defects for phenotyping and genotyping, animal modeling of birth defects, and human tissue generation. To support these efforts we propose two cores, the Integrated Genomics Core and this Administrative Core. The Administrative Core will play several essential roles in helping to coordinate and ultimately achieve these ambitious goals. Importantly, the administrative core will allow the principle investigators to focus on the clinical and scientific aspects of this program. The administrative core will be responsible for scientific administration and coordination, monitoring of scientific progress, personnel management, compliance with regulatory assurances, communication within the program, organizing an annual retreat in Cincinnati, financial administration and budget oversight, and to help coordinate the sharing of new reagents and model systems, as well as help with sharing data between projects.