Developmental Mechanisms of Trachea-Esophageal Birth Defects

气管食管先天缺陷的发育机制

• 批准号: 10174982
• 负责人: Aaron M Zorn
• 金额: $ 6.07万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10174982
• 关键词: Advisory Committees; Animal Model; Biological Models; Budgets; Clinical; Communication; Communication Programs; Congenital Abnormality; Development; Esophagus; Faculty; Generations; Genomics; Genotype; Goals; Institutes; Institution; Medical center; Monitor; Patient Recruitments; Pediatric Hospitals; Personnel Management; Phenotype; Play; Reagent; Research Personnel; Role; Site; Trachea; United States National Institutes of Health; Universities; data sharing; human tissue; meetings; programs

This program includes three integrated projects, across two institutions, Cincinnati Children’s Hospital Medical Center (CCHMC) and Columbia University and includes multiple divisions and institutes. The program proposes broad and ambitious aims that encompass recruitment of patients with tracheaesophageal birth defects for phenotyping and genotyping, animal modeling of birth defects, and human tissue generation. To support these efforts we propose two cores, the Integrated Genomics Core and this Administrative Core. The Administrative Core will play several essential roles in helping to coordinate and ultimately achieve these ambitious goals. Importantly, the administrative core will allow the principle investigators to focus on the clinical and scientific aspects of this program. The administrative core will be responsible for scientific administration and coordination, monitoring of scientific progress, personnel management, compliance with regulatory assurances, communication within the program, organizing an annual retreat in Cincinnati, financial administration and budget oversight, and to help coordinate the sharing of new reagents and model systems, as well as help with sharing data between projects.

该计划包括三个综合项目，横跨两个机构，辛辛那提儿童医院医学