权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Western States Node of the National Drug Abuse Treatment Clinical Trials Network

国家药物滥用治疗临床试验网络西部各州节点

基本信息

批准号：
10174894
负责人：
Keith N. Humphreys
金额：
$ 75.59万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10174894
关键词：
Academic Medical Centers Address Ambulatory Care Facilities American Behavioral Buprenorphine California Caring Clinical Clinical Treatment Clinical Trials Clinical Trials Network Clinics and Hospitals Cluster randomized trial Collaborations Complex Conduct Clinical Trials Data Data Science Data Set Disease Drug Use Disorder Drug abuse Drug usage Drug user Electronic Health Record Future General Practitioners Goals Health Health Sciences Health Services Health system Healthcare Hospitals Hybrids Hydromorphone Infrastructure Intervention Leadership Life Managed Care Medicaid Medical Mentors Methadone Methamphetamine Mirtazapine Morbidity - disease rate National Institute of Drug Abuse Neighborhood Health Center Opiate Addiction Oral Oregon Patient Care Patients Pharmaceutical Preparations Pharmacotherapy Placebos Policies Policy Maker Population Positioning Attribute Primary Health Care Protocols documentation Provider Public Health Publications Randomized Recording of previous events Recovery Research Research Personnel Research Support Resources Rural Community San Francisco Services Substance Use Disorder Supervision Techniques Telephone Testing Training Translating Trillium Universities Veterans Vulnerable Populations addiction advanced analytics base behavioral health care coordination care providers care systems data warehouse drug repurposing effective therapy effectiveness implementation study effectiveness implementation trial experience implementation trial improved innovation mHealth medical specialties methamphetamine use mortality multi-site trial novel opioid use disorder peer peer support phase III trial pragmatic trial prescription opioid protocol development substance use success telehealth treatment center trial comparing

项目摘要

Abstract The Western States Node's (WSN) research agenda for the National Drug Abuse Treatment Clinical Trials Network (CTN) competing renewal tests interventions to fill gaps in the Addiction Care Cascade, where progressively fewer people with drug use engage in treatment, receive pharmacotherapy, are retained in care, and experience sustained recovery. The Node proposes to continue the successful partnership between Oregon Health & Science University (OHSU; Todd Korthuis, MPI) and University of California San Francisco (UCSF; James Sorensen, Co-I), and adds Stanford University/Palo Alto VA (Keith Humphreys, MPI) to the collaboration. Six diverse health systems participate in WSN: 1) OCHIN, 2) The Palo Alto VA and national Veterans Healthcare Administration, 3) The OHSU health system, 4) Stanford Hospital and Clinics, 5) ProtoCall Services, Inc., and 6) Health Share and Trillium Medicaid managed care organizations. The WSN tests novel interventions that expand access to medications for opioid use disorder (MOUD). The overarching goal of the WSN's competing renewal application is to conduct collaborative research within the CTN that fills gaps in the Addiction Care Cascade and thereby enhances the lives of people living with drug use disorders. Our Addiction Care Cascade-focused research agenda developed through conversations with diverse investigators and stakeholders including people who use drugs. Two research themes (medication trials and hybrid implementation trials to close gaps in the Addiction Care Cascade) provide four examples of CTN studies that could help close treatment gaps. In Research Theme 1 (medication trials), Medication Trial 1 targets people with OUD who are not interested in currently available MOUD and randomizes them to receive long acting oral hydromorphone versus facilitated referral methadone or buprenorphine to improve engagement and retention in treatment. Medication Trial 2 is a multisite phase 3 trial of mirtazapine versus placebo for people with methamphetamine use disorder to reduce methamphetamine use. In Research Theme 2 (hybrid implementation trials), two trials compare strategies to enhance engagement and retention on MOUD. Hybrid Effectiveness-Implementation Trial 1 is a cluster- randomized trial of telephonic + mHealth behavioral support services to improve retention on buprenorphine in primary care. Hybrid Effectiveness-Implementation Trial 2 tests a telementoring peer support intervention versus weekly peer supervision to improve peer success in engaging and retaining people who use drugs in treatment. We suffuse this research agenda with the Node's infrastructure and expertise in vulnerable populations, health systems, electronic health records research, data science and clinical trials management. WSN offers these resources to the CTN network for use in future CTN protocols. Finally, WSN continues to use the CTN as a platform for training, dissemination, and research applications.

抽象的西部州节点 (WSN) 国家药物滥用治疗临床试验研究议程网络（CTN）竞争更新测试干预措施，以填补成瘾护理级联的空白，其中接受治疗、接受药物治疗、接受护理的吸毒者逐渐减少，并经历持续的康复。该节点建议继续双方之间的成功合作伙伴关系俄勒冈健康与科学大学 (OHSU; Todd Korthuis, MPI) 和加州大学旧金山分校（UCSF；James Sorensen，Co-I），并将斯坦福大学/帕洛阿尔托弗吉尼亚州（Keith Humphreys，MPI）添加到合作。六个不同的卫生系统参与 WSN：1) OCHIN，2) 帕洛阿尔托 VA 和国家退伍军人医疗保健管理局，3) OHSU 卫生系统，4) 斯坦福医院和诊所，5) ProtoCall Services, Inc.，以及 6) Health Share 和 Trillium Medicaid 管理式医疗组织。无线传感器网络测试新的干预措施，扩大阿片类药物使用障碍 (MOUD) 药物的获取范围。 WSN 竞争更新应用程序的总体目标是在 CTN 填补了成瘾护理级联的空白，从而改善了成瘾者的生活药物使用障碍。我们通过对话制定了以成瘾护理级联为重点的研究议程与不同的调查人员和利益相关者（包括吸毒者）合作。两个研究主题（药物试验和混合实施试验，以缩小成瘾护理级联中的差距）提供四种有助于缩小治疗差距的 CTN 研究示例。在研究主题 1（药物试验）中，药物试验 1 针对 OUD 患者，他们对当前可用的 MOUD 不感兴趣，并且将他们随机分配接受长效口服氢吗啡酮与便利转诊美沙酮或丁丙诺啡可提高治疗的参与度和保留率。药物试验 2 是多中心第 3 阶段米氮平与安慰剂对比甲基苯丙胺使用障碍患者的试验，以减少甲基苯丙胺的使用。在研究主题 2（混合实施试验）中，两项试验比较了以下策略：提高 MOUD 的参与度和保留率。混合有效性-实施试验 1 是一个集群- 电话+移动健康行为支持服务的随机试验，以提高丁丙诺啡的保留率初级保健。混合有效性-实施试验 2 测试远程辅导同伴支持干预与每周同伴监督相比，可以提高同伴在吸引和留住吸毒者方面的成功率治疗。我们在这个研究议程中加入了节点的基础设施和脆弱性方面的专业知识人口、卫生系统、电子健康记录研究、数据科学和临床试验管理。 WSN 向 CTN 网络提供这些资源，以便在未来的 CTN 协议中使用。最后，WSN 继续使用CTN作为培训、传播和研究应用的平台。