Building the brain: How mechanical forces shape human neural development
Building the brain: How mechanical forces shape human neural development
批准号:
10179706
负责人:
Medha M Pathak
金额:
$39.25万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-30 至 2023-08-31
关键词:
Biochemical GeneticsBiological ProcessBiomedical EngineeringBrainCellsCuesDevelopmentDevelopmental BiologyHumanKnowledgeLeadMeasuresMechanicsNeurodevelopmental DisorderOrganOrganoidsPatternProcessProgram DevelopmentProliferatingRoleShapesStructureWorkbiophysical techniquescellular transductionfetalinsightmechanical forcemolecular imagingneurodevelopmentpreventpublic health relevancetool
中文摘要
文摘:
英文摘要
Abstract:
As the brain develops, proliferating cells organize into structures, differentiate, migrate,
extrude long processes and connect with other cells. These biological processes produce
mechanical forces that shape cellular dynamics and organ patterning. A major unanswered
question in developmental biology is how the mechanical forces produced during development
are detected and transduced by cells to impact the biochemical and genetic programs of
development. New biophysical approaches are required to answer this question. We aim to
uncover the mechanical dynamics underlying human neural development by generating new
molecular, imaging and bioengineering tools. We will measure and manipulate mechanical forces
at different timepoints of human brain organoid formation. These studies will provide quantitative
and mechanistic insights on the role of mechanical forces during development, and demonstrate
how development fails when they are disrupted.
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会议论文
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批准号:10092758
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项目类别:
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资助金额:$2.15万
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财政年份:2020
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负责人:Medha M Pathak
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依托单位:
Building the brain: How mechanical forces shape human neural development
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批准号:10216450
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项目类别:
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资助金额:$15.7万
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Piezo1 in neural stem cell mechano-regulation
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批准号:9788548
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项目类别:
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资助金额:$34.28万
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财政年份:2018
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负责人:Medha M Pathak
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依托单位:
Piezo1 in neural stem cell mechano-regulation
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批准号:10207802
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项目类别:
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资助金额:$33.82万
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财政年份:2018
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负责人:Medha M Pathak
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依托单位:
Piezo1 in neural stem cell mechano-regulation
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批准号:10441343
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项目类别:
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资助金额:$33.82万
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财政年份:2018
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负责人:Medha M Pathak
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依托单位:
海外基金