Building the brain: How mechanical forces shape human neural development

构建大脑：机械力如何塑造人类神经发育

• 批准号: 10216450
• 负责人: Medha M Pathak
• 金额: $ 15.7万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216450
• 关键词: Biochemical Genetics; Biological Process; Biomedical Engineering; Brain; Cells; Cues; Development; Developmental Biology; Human; Knowledge; Lead; Measures; Mechanics; Neurodevelopmental Disorder; Organ; Organoids; Pattern; Process; Program Development; Proliferating; Role; Shapes; Structure; Work; biophysical techniques; cellular transduction; fetal; insight; mechanical force; molecular imaging; neurodevelopment; prevent; public health relevance; tool

Abstract: As the brain develops, proliferating cells organize into structures, differentiate, migrate, extrude long processes and connect with other cells. These biological processes produce mechanical forces that shape cellular dynamics and organ patterning. A major unanswered question in developmental biology is how the mechanical forces produced during development are detected and transduced by cells to impact the biochemical and genetic programs of development. New biophysical approaches are required to answer this question. We aim to uncover the mechanical dynamics underlying human neural development by generating new molecular, imaging and bioengineering tools. We will measure and manipulate mechanical forces at different timepoints of human brain organoid formation. These studies will provide quantitative and mechanistic insights on the role of mechanical forces during development, and demonstrate how development fails when they are disrupted.

抽象的： 随着大脑的发展，增殖细胞组织成结构，分化，迁移， 挤压长过程并与其他单元格连接。这些生物过程产生 塑造细胞动力学和器官模式的机械力。一个主要的未得到答复 发育生物学中的问题是开发过程中产生的机械力 细胞检测并转导，以影响 发展。需要新的生物物理方法来回答这个问题。我们的目标 通过产生新的人类神经发育的机械动力学来揭示机械动力学 分子，成像和生物工程工具。我们将测量和操纵机械力 在人类脑器官形成的不同时间点。这些研究将提供定量 以及机械力在开发过程中的作用的机理见解，并证明了 开发被破坏时如何失败。

项目成果

Mechanobiology of neural development.

• DOI: 10.1016/j.ceb.2020.05.012
• 发表时间: 2020-10
• 期刊: Current opinion in cell biology
• 影响因子: 7.5
• 作者: Abuwarda H;Pathak MM
• 通讯作者: Pathak MM