The influence of repetitive head impacts on motion perception

重复头部撞击对运动感知的影响

• 批准号: 10187694
• 负责人: Nicholas Murray
• 金额: $ 21.63万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10187694
• 关键词: Athletic; Behavior; Blindness; Brain; Brain Concussion; Characteristics; Control Groups; Data; Diagnosis; Eye Abnormalities; Eye Movements; Impairment; Institutes; Investigation; Knowledge; Manufactured football; Mission; Motion Perception; National Institute of Neurological Disorders and Stroke; Neurologic; Neurosciences; Observational Study; Participant; Performance; Research; Risk; Saccades; Seasons; Smooth Pursuit; Sports; Testing; Time; Visual Acuity; Visual Perception; base; behavioral impairment; head impact; innovation; nervous system disorder; novel; oculomotor; recruit; response; student athlete

The objective of this application will be to determine the lasting consequences of repetitive head impacts (RHIs) on motion perception and oculomotor response during dynamic visual acuity (DVA). The specific aims of this project are to (1) examine the effect of RHI on oculomotor control over a single athletic season and (2) does RHIs impair motion perception after a single athletic season? The proposed research is consistent with NINDS’s mission to seek fundamental knowledge about the brain to use that knowledge to reduce the burden of neurological disease. It is hypothesized the presence of RHIs will result in smooth pursuit gain, saccadic magnitude and peak saccadic velocity decreases along with a loss of visual acuity during the DVA tasks over the single season of contact sports. To test these hypotheses, the proposed research will institute a observational study that involves assessing oculomotor control and behavior on adaptive DVA tasks from pre-, mid-, and post-season of a single season of RHIs, that are independent of a sport-related concussion, as compared to non-RHIs controls. Thirty-five athletes from both the RHIs and control group will be recruited from Division I student-athlete football players and non-contact controls. Participants will be excluded if they have a diagnosed sport-related concussion during the single athletic season or if they have a prior existing neurological condition. Based on the pilot data, it is expected to see impaired smooth pursuit gain and saccadic mean/peak velocity in the RHI group over time. It is predicted this will lead to visual acuity loss and impaired behavioral performance in visual perception tasks. This project is innovative as little is known regarding the consequence of RHIs. The findings will be the first to assess if motion perception is altered as a result of RHIs and whether this potential DVA loss is a result of abnormal eye movements. In addition, this study will be the first to examine the characteristics of SPEMs and saccades in the presence of RHIs. These novel investigations have not been previously established and should be further evaluated to understand the risk of RHIs.

本申请的目的是确定在动态视敏度（DVA）期间重复头部撞击（RHI）对运动感知和眼动反应的持久后果。本项目的具体目的是（1）检查RHI对单个运动赛季的眼动控制的影响，（2）RHI是否会在单个运动赛季后损害运动感知？这项拟议中的研究与NINDS的使命是一致的，即寻求有关大脑的基本知识，并利用这些知识来减轻神经系统疾病的负担。假设RHI的存在将导致在接触性运动的单个季节中在DVA任务期间平滑的追踪增益、扫视幅度和峰值扫视速度降低沿着视力的丧失。为了验证这些假设，拟议的研究将进行一项观察性研究，包括评估RHIs单季的季前、季中和季后适应性DVA任务的眼动控制和行为，与非RHIs对照相比，这些任务独立于运动相关的脑震荡。将从第一组学生运动员足球运动员和非接触性对照组中招募来自RHI和对照组的35名运动员。参与者将被排除在外，如果他们有一个诊断运动相关的脑震荡在单一的运动赛季，或者如果他们有一个先前存在的神经系统疾病。基于导频数据，预期随着时间的推移在RHI组中看到受损的平滑追踪增益和扫视平均/峰值速度。据预测，这将导致视敏度丧失和视觉感知任务中的行为表现受损。该项目具有创新性，因为人们对RHI的后果知之甚少。这些发现将首次评估RHI是否会改变运动感知，以及这种潜在的DVA丧失是否是异常眼球运动的结果。此外，这项研究将是第一个研究的特点，SPEM和眼跳的存在RHI。这些新的研究之前尚未建立，应进一步评估以了解RHI的风险。