Vevo 3100 ultrasound scanner and PV loop system

杰斐逊高频超声核心设施提供临床前成像服务， 托马斯杰斐逊大学（TJU）的调查人员。Vevo 2100超声系统（FujiFilm VisualSonics多伦多，安大略，加拿大），该公司于2011年根据授予Dr Flemming Forsberg（本申请的PI）能够实现无创高分辨率成像， 组织微环境的光声量化。常用的应用程序包括 分析多个心脏功能参数，包括射血分数，缩短分数， 尺寸、体积、壁厚等，原位肿瘤和器官体积定量，血管分布 监测，非线性对比成像，超声触发药物释放工作，对比增强 光声成像和组织氧合水平的定量。我们对动物模型进行了成像 范围从果蝇幼虫到兔子，但主要由小鼠和大鼠组成。在过去的十年里， 该系统已被20多名杰斐逊教师使用。这导致了无数的 出版物和正在进行的研究合作。目前，该系统由14个国家卫生研究院使用。 资助的调查人员及其运作对这些赠款的进展至关重要。这些研究者 跨多个TJU部门，包括放射学，医学，整形外科和病理学。 然而，VisualSonics已经宣布，它将不再提供2100模型线的服务。 因此，该申请要求提供资金购买更新的Vevo 3100 LAZR-X系统，该系统将 在可预见的未来提供可靠的小动物扫描能力，同时还提供 在2100型的多个领域进行了重大技术升级。此外，我们还将获得 来自Data Sciences International的压力-体积回路记录系统，该系统使用不同的 植入监测器，以检测体内真实生理参数，最重要的是，可以直接 与Vevo 3100系统连接。该系统的所有选定主要用户都在不断 以及资金充足的联邦研究计划，这些计划目前和未来需要体内成像， 动物模型在癌症生物学、心血管疾病和新兴疾病中的转化应用 分子疗法Vevo 3100超声扫描仪和压力-容积环 记录系统是真正的最先进的体内成像和测量系统， 没有平等的，小动物。因此，这些系统将大大促进广泛的， 联邦政府支持的小型动物研究项目

The Jefferson High Frequency Ultrasound Core Facility provides preclinical imaging services to investigators across Thomas Jefferson University (TJU). A Vevo 2100 ultrasound system (FujiFilm VisualSonics Toronto, Ontario, Canada), which was acquired in 2011 under an S10 awarded to Dr Flemming Forsberg (the PI of this application) enables noninvasive high-resolution imaging as well as opto-acoustic quantification of the tissue microenvironment. Frequently used applications include analysis of multiple cardiac functional parameters including ejection fraction, fractional shortening, dimensions, volumes, wall thickness, etc., orthotopic tumor and organ volume quantification, vascularity monitoring, nonlinear contrast imaging, ultrasound-triggered drug delivery work, contrast-enhanced photoacoustic imaging, and quantification of tissue oxygenation levels. Animal models we have imaged range from fruit fly larvae to rabbits, but primarily consist of mice and rats. Over the last decade, the system has been used by more than 20 Jefferson faculty members. These have resulted in a countless publications and ongoing research collaborations. At the current time, the system is utilized by 14 NIH funded investigators and its operation is crucial to the progress of these grants. These investigators span multiple TJU departments including Radiology, Medicine, Orthopedic Surgery, and Pathology. However, VisualSonics has announced that it will no longer provide service on the 2100 model line. Hence, this application requests funding to purchase the newer Vevo 3100 LAZR-X system, which will provide reliable small animal scanning capabilities for the foreseeable future, while also offering significant technological upgrades in multiple areas over the 2100 model. Moreover, we will acquire a pressure-volume loop recording system from Data Sciences International, which uses different implanted monitors to detect in vivo real-physiological parameters, and, most importantly, can be directly linked together with the Vevo 3100 system. All the selected major users of this system have ongoing and well-funded federal research programs that have the current and future needs of in vivo imaging of animal models for translational applications in cancer biology, cardiovascular disease and emerging molecular therapies. The Vevo 3100 ultrasound scanner together with the pressure-volume loop recording system is truly the state-of-the-art in vivo imaging and measurement system dedicated to, and without equal for, small animals. Consequently, these systems will be a major boost to the extensive, federally supported, small animal research efforts at TJU.