Vevo 3100 ultrasound scanner and PV loop system

杰斐逊高频超声核心设备提供临床前成像服务 托马斯·杰斐逊大学(TJU)的调查人员。Vevo 2100超声波系统(Fujifilm Visualsonics，加拿大安大略省多伦多)，该公司于2011年根据授予Dr Flemming Forsberg(此应用程序的PI)支持非侵入性高分辨率成像以及 组织微环境的光声量化。常用应用程序包括 分析多项心功能参数，包括射血分数、短轴缩短率、 大小、体积、壁厚等、原位肿瘤和器官体积量化、血管 监测，非线性对比成像，超声触发的药物输送工作，对比增强 光声成像和组织氧合水平的量化。我们想象的动物模型 范围从果蝇幼虫到兔子，但主要由小鼠和大鼠组成。在过去的十年里， 该系统已被20多名杰斐逊教职员工使用。这些都导致了无数的 出版物和持续的研究合作。目前，该系统被14个NIH使用 资助的调查员及其运作对这些赠款的进展至关重要。这些调查人员 跨越多个TJU科室，包括放射科、内科、整形外科和病理学。 然而，Visualsonics已经宣布将不再在2100型号线上提供服务。 因此，该应用程序申请资金购买较新的Vevo 3100 LAZR-X系统，这将 在可预见的未来提供可靠的小型动物扫描功能，同时还提供 在2100型号的基础上，在多个领域进行了重大技术升级。此外，我们还将获得一个 数据科学国际公司的压力-体积回路记录系统，该系统使用不同的 植入监测器来检测体内的真实生理参数，最重要的是，可以直接 与Vevo 3100系统连接在一起。该系统的所有选定主要用户都在进行 以及资金充足的联邦研究项目，这些项目目前和未来都需要活体成像 翻译应用于癌症生物学、心血管疾病和新兴疾病的动物模型 分子疗法。Vevo 3100超声波扫描仪与压力-体积回路一起使用 记录系统是真正最先进的活体成像和测量系统，致力于 没有平等的对待，小动物。因此，这些系统将对广泛的、 联邦政府支持的，TJU的小型动物研究工作。

The Jefferson High Frequency Ultrasound Core Facility provides preclinical imaging services to investigators across Thomas Jefferson University (TJU). A Vevo 2100 ultrasound system (FujiFilm VisualSonics Toronto, Ontario, Canada), which was acquired in 2011 under an S10 awarded to Dr Flemming Forsberg (the PI of this application) enables noninvasive high-resolution imaging as well as opto-acoustic quantification of the tissue microenvironment. Frequently used applications include analysis of multiple cardiac functional parameters including ejection fraction, fractional shortening, dimensions, volumes, wall thickness, etc., orthotopic tumor and organ volume quantification, vascularity monitoring, nonlinear contrast imaging, ultrasound-triggered drug delivery work, contrast-enhanced photoacoustic imaging, and quantification of tissue oxygenation levels. Animal models we have imaged range from fruit fly larvae to rabbits, but primarily consist of mice and rats. Over the last decade, the system has been used by more than 20 Jefferson faculty members. These have resulted in a countless publications and ongoing research collaborations. At the current time, the system is utilized by 14 NIH funded investigators and its operation is crucial to the progress of these grants. These investigators span multiple TJU departments including Radiology, Medicine, Orthopedic Surgery, and Pathology. However, VisualSonics has announced that it will no longer provide service on the 2100 model line. Hence, this application requests funding to purchase the newer Vevo 3100 LAZR-X system, which will provide reliable small animal scanning capabilities for the foreseeable future, while also offering significant technological upgrades in multiple areas over the 2100 model. Moreover, we will acquire a pressure-volume loop recording system from Data Sciences International, which uses different implanted monitors to detect in vivo real-physiological parameters, and, most importantly, can be directly linked together with the Vevo 3100 system. All the selected major users of this system have ongoing and well-funded federal research programs that have the current and future needs of in vivo imaging of animal models for translational applications in cancer biology, cardiovascular disease and emerging molecular therapies. The Vevo 3100 ultrasound scanner together with the pressure-volume loop recording system is truly the state-of-the-art in vivo imaging and measurement system dedicated to, and without equal for, small animals. Consequently, these systems will be a major boost to the extensive, federally supported, small animal research efforts at TJU.