Quadrupole-Orbitrap Mass Spectrometer

四极杆轨道阱质谱仪

• 批准号: 10177083
• 负责人: David Roger Quilici
• 金额: $ 60万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2022-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177083
• 关键词: Address; Award; Biomedical Research; Centers of Research Excellence; Clinical; Development; Funding; Grant; Network Infrastructure; Nevada; Post-Translational Modification Site; Proteins; Proteomics; Request for Proposals; Research Personnel; Signal Pathway; Time; United States National Institutes of Health; biomarker discovery; instrument; mass spectrometer; personalized medicine; translational medicine

Project Summary/Abstract This proposal requests funding for a Thermo Scientific Exploris 480 to support NIH Institutional Development Award (IDeA) centers in the state of Nevada and NIH R01 funded researchers. A significant portion of the instrument time would be to address the proteomic needs of three IDeA center grants, Nevada IDeA Network of Biomedical Research Excellence (NV-INBRE), Personalized Medicine Center of Biomedical Research Excellence (COBRE) and the Mountain West Clinical Translational Medicine- Infrastructure Network (CTR-IN). The Exploris 480 will allow researchers to perform new types of proteomic studies including DIA protein quantitation for biomarker discovery and post-translational modification (PTM) site mapping for pathway signal analysis. The proposed Thermo Scientific Exploris 480 will be operated and maintained by the Nevada Proteomic Center.

项目总结/摘要 该提案要求为Thermo Scientific Exploris 480提供资金，以支持NIH 内华达州和NIH R 01的机构发展奖（IDEA）中心 资助的研究人员。仪器的很大一部分时间将用于解决 三个IDEA中心赠款的蛋白质组学需求，内华达州IDEA生物医学网络 卓越研究（NV-INBRE），生物医学个性化医学中心 卓越研究（COBRE）和西山临床转化医学- 基础设施网络（CTR-IN）。Exploris 480将允许研究人员执行新的 蛋白质组学研究的类型，包括用于生物标志物发现的DIA蛋白质定量， 翻译后修饰（PTM）位点定位用于途径信号分析。的 拟议的Thermo Scientific Exploris 480将由内华达州运营和维护 蛋白质组学中心。