Quadrupole-Orbitrap Mass Spectrometer

项目摘要/摘要 该提案要求为热科学探索480项目提供资金，以支持美国国立卫生研究院 机构发展奖(IDEA)中心设在内华达州和NIH R01 资助研究人员。工具时间的很大一部分将是解决 三个IDEA中心拨款的蛋白质组需求，内华达州IDEA生物医学网络 NV-INBRE生物医学个性化医学中心 卓越研究(科布雷)和西部山区临床转化医学- 基础设施网络(CTR-IN)。Exploris 480将允许研究人员执行新的 蛋白质组学研究的类型，包括DIA蛋白质定量以发现生物标记物和 翻译后修饰(PTM)定位图用于通路信号分析。这个 拟议的Thermo Science Exploris 480将由内华达州号运营和维护 蛋白质组中心。

Project Summary/Abstract This proposal requests funding for a Thermo Scientific Exploris 480 to support NIH Institutional Development Award (IDeA) centers in the state of Nevada and NIH R01 funded researchers. A significant portion of the instrument time would be to address the proteomic needs of three IDeA center grants, Nevada IDeA Network of Biomedical Research Excellence (NV-INBRE), Personalized Medicine Center of Biomedical Research Excellence (COBRE) and the Mountain West Clinical Translational Medicine- Infrastructure Network (CTR-IN). The Exploris 480 will allow researchers to perform new types of proteomic studies including DIA protein quantitation for biomarker discovery and post-translational modification (PTM) site mapping for pathway signal analysis. The proposed Thermo Scientific Exploris 480 will be operated and maintained by the Nevada Proteomic Center.