An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-II

用于 NSLS-II NYSBC 操作的 NYX 光束线的 Eiger2 XE 9M 探测器

• 批准号: 10176813
• 负责人: KEVIN P BATTAILE
• 金额: $ 179.47万
• 依托单位: NEW YORK STRUCTURAL BIOLOGY CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176813
• 关键词: Area; Communities; Crystallography; Data Collection; Funding; Institution; Laboratories; Light; Methods; Modernization; New York; Photons; Radiation induced damage; Research; Roentgen Rays; Sampling; Services; Source; Speed; Structural Biologist; Synchrotrons; System; Time; United States National Institutes of Health; beamline; data quality; detector; expectation; member; programs; prototype; structural biology

Project Summary The New York Structural Biology Center (NYSBC) owns and operates the NYX beamline at the National Synchrotron Light Source II (NSLS-II) which is located at the Brookhaven National Laboratory (BNL) and operated for the benefit of the member institutions of the NYSBC and the community of non-consortium-member structural biologists. We seek funds to acquire a Dectris Eiger2 XE 9M X-ray detector for macromolecular crystallography. This advanced, high-speed readout of the detector will significantly increase the throughput of samples and therefore increase the number of projects that can be prosecuted in a set amount of time. The high frame rate will allow us to perform advanced crystallographic methods that are not possible with our current experimental setup, such as serial crystallography, ultra-fast rastering and potentially outrunning radiation damage during data collection. NYX has been operating with a prototype pixel array detector from Area Detector Systems Corporation (HF-4M) since its inception at NSLS-II. While the data quality from this detector has been comparable with other available detectors, ADSC ceased to operate several years ago with the result that the detector is no longer serviceable and is starting to fail. In order to remain valuable to users, it is imperative that we replace the ADSC HF-4M with a modern pixel array detector with the expectation that it will remain useful and serviceable for the next 8-10 years. Of particular importance is performing this upgrade prior to the temporary shutdown of the Advanced Photon Source for a facility upgrade in 2022 when the demand for synchrotron access for NIH-funded projects is expected to increase dramatically. Having this detector in place in 2021 will allow NYX to significantly enhance the NIH-funded research programs of the NYSBC consortium members, non- consortium members as well as be fully prepared to provide uninterrupted access to NIH-funded projects due to the temporary closure of the APS.

项目概要 纽约结构生物学中心 (NYSBC) 拥有并运营 NYX 光束线 位于布鲁克海文的国家同步加速器光源 II (NSLS-II) 国家实验室（BNL）并为该联盟成员机构的利益而运营 NYSBC 和非联盟成员结构生物学家社区。我们寻求 资金购买 Dectris Eiger2 XE 9M 大分子 X 射线检测器 晶体学。这种先进的高速读出探测器将显着 增加样本的吞吐量，从而增加可以进行的项目数量 在规定的时间内受到起诉。高帧率将使我们能够执行 我们目前的实验无法实现的先进晶体学方法 设置，例如串行晶体学、超快光栅和潜在的超越 数据收集过程中的辐射损伤。 NYX 一直在使用原型像素进行操作 Area Detector Systems Corporation (HF-4M) 自成立以来的阵列探测器 NSLS-II。虽然该检测器的数据质量与其他检测器相当 可用的探测器，ADSC 几年前就停止运行，结果是 探测器不再可用并且开始出现故障。为了保持价值 用户，我们必须用现代像素阵列替换 ADSC HF-4M 探测器，预计在接下来的 8-10 年内仍能保持有用和可用 年。特别重要的是在临时升级之前执行此升级 2022 年关闭先进光子源以进行设施升级 NIH 资助项目对同步加速器接入的需求预计将会增加 戏剧性地。 2021 年安装此探测器将使 NYX 能够显着 加强 NIH 资助的 NYSBC 联盟成员、非 联盟成员并做好充分准备，提供不间断的访问 由于 APS 暂时关闭，NIH 资助的项目。