Trauma Research Fellowship

项目摘要/摘要 我们提出了一项培训计划，每年招募两名博士后学者，获得为期两年的奖学金 致力于创伤的病理生理学研究。该培训计划的目标是培养 基础、翻译和临床研究领域的有才华的人，教他们设计和 实施成功的研究项目，并为他们提供道德和方法方面的背景 科学研究。我们特别感兴趣的是培养将成为下一代 与创伤、烧伤的生理反应和恢复有关的几个领域的研究人员，以及 创伤性休克，如炎症和免疫因素，复苏机制，脓毒症， 失血性休克，器官系统功能障碍，伤口愈合和再生。 培训计划包括两年的全职工作，在一人或一人的监督下进行研究 更多的是有才华的研究培训学院导师，通常涉及跨 学科和部门。实习生的任命从为期三天的负责任行为课程开始 在研究和其他几项旨在保护妇女和儿童权利和福利的培训活动中 对人体受试者进行研究以及人文关怀和使用的监管要求 实验动物。此外，研究员完成公共卫生硕士(公共卫生硕士)学位，重点 生物统计学，医学文献的批判性评价，研究方法，项目管理，以及 格兰特精神，以及正在进行的每周研讨会。受训者被要求在GRAND展示他们的研究成果 向全国会议提交摘要，并发表他们的工作。 计划领导包括一个培训咨询委员会，以协助计划主任招聘和 选择学员，批准学员研究和教学计划，将学员与研究型培训配对 教职员工，并监测计划活动，以及一个计划评估委员会，以提供整体计划 评估。多样性招聘和保留委员会协助方案联合主任努力 吸引和留住代表性不足的群体的成员，以增加培训计划的多样性。 该计划中的所有研究培训学院都是现任NIH或其他机构的资深研究人员 校外资助，是经验丰富的内科科学家导师。教职员工有不同的 兴趣，允许多名候选人在培训计划内找到合适的导师，并且有 深厚的多学科协作机构历史。临床医生-科学家导师提供职业 就当代学者扮演的多重角色向受训者提供指导和额外支持 创伤和烧伤外科医生参与研究、临床、教育和外展活动。 对学术创伤和烧伤外科医生的需求日益增长，以指导后续的 并引领创新疗法的发展。这笔赠款旨在帮助满足这一需求。

Project Summary/Abstract We propose a training program that will recruit two postdoctoral scholars per year for a two-year fellowship devoted to research on the pathophysiology of trauma. The goals of this training program are to nurture talented individuals in the areas of basic, translational, and clinical investigation, to teach them to design and implement successful research projects, and to provide them a background in the ethics and methods of scientific research. We are particularly interested in training individuals who will become the next generation of investigators in several areas related to the physiologic response to and recovery from trauma, burn, and traumatic shock, such as inflammatory and immunologic factors, resuscitative mechanisms, sepsis, hemorrhagic shock, organ system dysfunction, and wound healing and regeneration. The training program includes two years of full-time effort conducting research under the supervision of one or more of a large group of talented Research Training Faculty mentors, often involving collaboration across disciplines and departments. Trainee appointments begin with a three-day course in the Responsible Conduct of Research and in several other training activities geared toward protection of the rights and welfare of and the regulatory requirements for conducting research with human subjects and for the humane care and use of laboratory animals. In addition, fellows complete a Master’s of Public Health (MPH) degree, with an emphasis in biostatistics, critical appraisal of medical literature, research methodology, project management, and grantsmanship, as well as ongoing weekly seminars. Trainees are required to present their research at grand rounds and research conferences, to submit abstracts to national meetings, and to publish their work. Program leadership includes a Training Advisory Committee to assist the Program Director in recruiting and selecting trainees, approving trainee research and didactic plans, matching trainees with Research Training Faculty, and monitoring of program activities, and a Program Evaluation Committee to provide overall program evaluation. The Diversity Recruitment and Retention Committee assists the Program Co-Director in efforts to attract and retain members of underrepresented groups to increase the diversity of the training program. All of the Research Training Faculty in the program are established investigators with current NIH or other extramural funding and are experienced mentors of physician-scientists. Faculty members have diverse interests, allowing multiple candidates to find appropriate mentors within the training program, and there is a strong institutional history of multidisciplinary collaboration. Clinician-Scientist mentors provide career guidance and additional support to trainees with regard to the multiple roles filled by contemporary academic trauma and burn surgeons involved in research, clinical, educational, and outreach activities. There is a growing demand for academic trauma and burn surgeons to guide subsequent generations of providers and lead the development of innovative treatments. This grant is designed to help meet this need.