Uncovering mechanisms of protein multifunctionality

揭示蛋白质多功能性的机制

• 批准号: DP210100998
• 负责人: Prof Paul Gooley
• 金额: $ 44.89万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-07-02 至 2025-07-01
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100998
• 关键词: Uncovering; mechanisms; protein; multifunctionality

This project aims to use viral proteins to uncover fundamental mechanisms underlying protein multifunctionality, a central but poorly understood aspect of biology. This project expects to use multidisciplinary approaches to define novel and unexpected mechanisms by which single protein sequences can generate proteins with profoundly different structures and functions. Expected outcomes include a major shift in the understanding of protein function in life, with most immediate impact in virology. This should provide significant benefits in identifying new strategies for treating viral infections, but also enhance developing multidisciplinary approaches to solve complex biological problems.

该项目旨在利用病毒蛋白揭示蛋白质多功能性的基本机制，这是生物学的一个核心但鲜为人知的方面。该项目期望使用多学科方法来定义新的和意想不到的机制，通过这些机制，单个蛋白质序列可以产生具有完全不同结构和功能的蛋白质。预期结果包括对生命中蛋白质功能的理解发生重大转变，对病毒学产生最直接的影响。这将为确定治疗病毒感染的新策略提供显著的好处，但也将促进发展多学科方法来解决复杂的生物学问题。