Imaging Core

项目摘要：耶鲁大学ADRC成像核心 耶鲁大学阿尔茨海默病研究中心的总体目标是促进对阿尔茨海默病的理解和治疗 阿尔茨海默病(AD)。这项工作需要集成广泛的核心职能，包括临床、 神经病理学和神经成像。人体成像研究允许开发成像生物标记物 AD病理的时间序列的特征，并导致更好地将患者分配到 临床研究和临床试验。成像是耶鲁大学的一个主要优势，广度就是例证 和深度，由耶鲁PET中心和耶鲁磁共振研究中心(MRRC)提供。在 宠物中心，最近重要工作的一个例子是引入了带有SV2A的PET突触成像 示踪剂11C-UCB-J在核磁共振方面，耶鲁大学的MRRC已经产生了许多新的方法来表征 个体的功能连接体，并将功能组织与行为和临床变量联系起来 总体而言，这两个中心开发了尖端成像技术，并应用这些技术来回答 重要的临床问题。通过创建这个耶鲁ADRC图像核心(YAIC)，我们利用 了解耶鲁大学的成像优势，提供最先进的成像数据采集和分析 专注于开发应对AD的新方法。YAIC将为以下项目提供公共基础设施 获取、处理和分析多模式成像数据，以支持和培训AD调查人员和 开发下一代成像工具。当前和未来的方法将应用于正在进行的 成像研究，以获取丰富的，多方面的和多模式的数据集在人类受试者。此外， 本程序的翻译部分考察了非人灵长类动物(NHP)作为模型的效用 人类公元前。成像核心将实现以下具体目标：目标1：开发和优化PET 图像和数据分析战略，以促进受试者内部和之间的比较。多重示踪剂在- 受试者的相关性很重要，涉及淀粉样蛋白、tau蛋白、突触密度和葡萄糖代谢。目标2：实现 增强我们基于MR的功能连接组建模，以更好地表现患者的功能表型和联系 大脑与行为的关系。这种方法在本地化网络时为每个人提供了一个功能配置文件 揭示了支撑这些功能的网络组织原则。目标三：发展和丰富多元文化 受试者内和受试者间研究中正电子发射计算机断层扫描和功能磁共振成像之间的模式分析。功能磁共振成像的结合- 基于PET可测量的神经变性区域模式的连通性提供了理想的 有机会了解疾病发展的途径。目标4：扩展方法论 开发用于对NHP数据进行人工分析。正在进行的老年卫生保健计划研究，提供了 将活体PET和MR成像与死后测量进行比较的机会 神经病理学核心。

Project Summary: Yale ADRC Imaging Core The Yale Alzheimer Disease Research Center has the overall goal to advance understanding and treatment of Alzheimer’s disease (AD). This effort requires integration of a wide array of core functions, including Clinical, Neuropathology, and Neuroimaging. Human imaging studies allow for the development of imaging biomarkers of AD, characterization of the temporal sequence of AD pathology, and lead to better assignment of patients to clinical research studies and clinical trials. Imaging is a major strength at Yale, as exemplified by the breadth and depth offered by the Yale PET Center and the Yale Magnetic Resonance Research Center (MRRC). In the PET Center, an example of recent significant work is the introduction of PET synaptic imaging with the SV2A tracer 11C-UCB-J. In MRI, the Yale MRRC has generated numerous novel methods to characterize an individual’s functional connectome and relate the functional organization to behavior and clinical variables Overall, these two Centers develop cutting edge imaging technologies and apply these techniques to answer important clinical questions. By creating this Yale ADRC Imaging Core (YAIC), we leverage the vast experience of Yale’s imaging strengths to provide state-of-the-art acquisition and analysis of imaging data and to focus on the development of novel approaches to AD. The YAIC will provide a common infrastructure for acquisition, processing, and analysis of multimodal imaging data, to support and train AD investigators and develop the next generation of imaging tools. The current and future methods will be applied to ongoing imaging studies to acquire a rich, multi-faceted and multi-modality dataset in human subjects. In addition, the translational component of this program examines the utility of nonhuman primates (NHPs) as a model for human AD. The Imaging Core will perform the following specific aims: Aim 1: To develop and optimize PET image and data analysis strategies to facilitate within- and between-subject comparisons. Multi-tracer within- subject correlations are important, involving amyloid, tau, synaptic density, and glucose metabolism. Aim 2: To enhance our MR-based functional connectome modeling to better functionally phenotype patients and link brain to behavior. This approach provides a functional profile for each individual while localizing the networks and revealing the network organizing principles supporting these functions. Aim 3: To develop and enrich multi- modality analyses between PET and fMRI for within- and between-subject studies. The combination of fMRI- based connectivity with the regional patterns of neurodegeneration measurable with PET provides an ideal opportunity for understanding the pathways of disease progression. Aim 4: To extend the methodologies developed for human analysis to NHP data. Ongoing studies in aged NHPs are being performed, providing the opportunity to compare in vivo PET and MR imaging with post-mortem measures provided by the Neuropathology Core.