Imaging Core

成像核心

• 批准号: 10652566
• 负责人: Richard E. Carson
• 金额: $ 51.96万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10652566
• 关键词: Adverse effects; Blood; Blood specimen; Brain imaging; Calibration; Clinical; Clinical Data; Data; Data Analyses; Data Storage and Retrieval; Dedications; Development; Devices; Drug Addiction; Environment; Equipment; Generations; Goals; Human; Image; Image Analysis; Imaging Device; Infrastructure; Institutional Review Boards; Kinetics; Laboratories; Methodology; Methods; Mission; Molecular; Monitor; Multi-Institutional Clinical Trial; Participant; Patients; Pennsylvania; Physics; Pilot Projects; Positron-Emission Tomography; Procedures; Protocols documentation; Radiation; Radiochemistry; Reporting; Research; Research Design; Research Personnel; Resolution; Resources; Safety; Scheme; Services; Time; Tracer; Universities; Work; addiction; archive data; data archive; data exchange; design; dosimetry; experience; image archival system; image reconstruction; imaging agent; imaging capabilities; imaging facilities; imaging modality; imaging study; instrumentation; novel; opioid use disorder; parametric imaging; protocol development; radiotracer

IMAGING CORE The Penn PET Addiction Center of Excellence (PACE) Imaging Core will support the design, implementation, execution, and analysis of the PET imaging components of the Center's pilot projects. The Imaging Core will function as a resource for expertise and guidance for investigators and will also serve as a functioning platform to provide services for P30 investigators that include imaging study design, imaging study execution including imaging-related patient coordination, image analysis, PET image data archiving, and regulatory support. As such, the Imaging Core will work closely with the other Cores and the PIs of the P30 Core Center's pilot projects to support the Center's mission in drug addiction research and to expand the scope of PET imaging for research on opiate use disorders at Penn and Yale University. Specific aims of the Imaging Core include: 1) to design the PET components of the Penn PACE pilot core projects; 2) to coordinate and execute PET imaging studies proposed in the Pilot Core at Penn and at Yale; 3) to guide and execute PET image analyses, including kinetic analysis and novel image analysis approaches; and (4) to guide and support regulatory submissions and provide oversight of imaging studies by working closely with the other Cores on data and safety monitoring for the PET imaging component of Pilot Core projects. The Imaging Core is co-led by Dr. David Mankoff of Penn and Dr. Richard Carson of the Yale University PET Center. The Imaging Core takes advantage of a highly developed infrastructure for human PET imaging research at both the Penn and the Yale University PET Centers. The core also benefits from synergistic expertise at Penn (multi-center clinical trials, protocol development, regulatory infrastructure) and Yale (molecular brain imaging methodology, tracer kinetic analysis). The Core has a unusual depth of combined depth of expertise in PET instrumentation physics, image generation, and data analysis – along with dedicated unique scanner resources- to support the scientific mission of this P30 Center.

成像核心 宾州PET成瘾卓越中心（PACE）成像核心将支持设计，实施， 执行和分析该中心试点项目的PET成像组件。成像核心将 作为调查人员的专门知识和指导资源，还将作为一个运作平台 为P30研究者提供服务，包括成像研究设计、成像研究执行，包括 与成像相关的患者协调、图像分析、PET图像数据存档和监管支持。作为 因此，成像核心将与P30核心中心试点的其他核心和PI密切合作 支持该中心在药物成瘾研究方面的使命和扩大PET成像范围的项目 在宾夕法尼亚大学和耶鲁大学进行阿片类药物使用障碍的研究。成像核心的具体目标包括： 1)设计宾夕法尼亚大学PACE试点核心项目的PET组件; 2）协调和执行PET 在Penn和Yale的Pilot Core中提出的成像研究; 3）指导和执行PET图像分析， 包括动力学分析和新的图像分析方法;（4）指导和支持监管 提交并通过与其他核心就数据和 试点核心项目PET成像部分的安全监测。成像核心由Dr. 宾夕法尼亚大学的大卫曼科夫和耶鲁大学PET中心的理查德卡森博士。成像核心需要 宾夕法尼亚大学和耶鲁大学高度发达的人体PET成像研究基础设施的优势 大学PET中心。核心还受益于宾夕法尼亚大学的协同专业知识（多中心临床试验， 协议开发，监管基础设施）和耶鲁大学（分子脑成像方法，示踪动力学 分析）。核心在PET仪器物理学方面有着不同寻常的专业知识， 图像生成和数据分析-沿着专用的独特扫描仪资源-以支持科学 这个P30中心的使命。