Clinical Scholars Biomedical Research Training Program

项目摘要 纪念斯隆-凯特琳癌症中心的临床学者生物医学研究培训计划 （MSKCC）为杰出的医学博士或 医学博士/博士由大卫斯普里格斯博士领导。该计划的目标是准备高素质的医生，科学家 从事癌症生物学和临床研究的工作。研究员由校长培训 研究人员具有非常广泛的科学兴趣，涵盖了现代癌症的大部分领域 research. 44名导师中有一半以上是医生科学家，他们是强有力的榜样 结合实验室和临床研究和实践的职业。该计划包括一个结构化和 有凝聚力的两年制课程，结合实验室研究，在癌症生物学的教学课程工作， 生物信息学培训和职业发展讲习班。学员可以使用 纪念斯隆-凯特琳癌症中心，一个基础，转化和临床研究的机构 活动在高度协作的研究环境中近距离进行。的研究范畴 主要重点包括：1）人类癌症生物学，小鼠癌症模型，遗传学和分子生物学 病理学; 2）药物开发和基于机制的治疗; 3）参与的信号和途径 细胞增殖的控制; 4）发育生物学和细胞分化中涉及的调节途径; 5)细胞-细胞相互作用、粘附和蛋白质靶向; 6）肿瘤免疫学、免疫疗法和免疫治疗。 移植生物学临床学者生物医学研究培训计划已经有了很长的时间， 成功的培训历史，几乎所有的毕业生继续在高生产力的研究生涯。 因此，该计划在满足国家对医生科学家的需求方面产生了重大影响，他们可以 在将癌症生物学的基本发现转化为患者护理方面发挥主导作用。

PROJECT SUMMARY The Clinical Scholars Biomedical Research Training Program at Memorial Sloan-Kettering Cancer Center (MSKCC) provides a mentored laboratory training experience in cancer research for outstanding MD's or MD/PhD's led by Dr. David Spriggs. The goal of the Program is to prepare highly qualified physician-scientists for a career at the interface of cancer biology and clinical research. The fellows are trained by principal investigators with an exceptionally broad range of scientific interests spanning most areas of modern cancer research. More than one half of the 44 preceptors are physician scientists, who represent strong role models for careers combining laboratory and clinical research and practice. The Program consists of a structured and cohesive two-year curriculum that combines laboratory research, didactic course work in cancer biology, bioinformatics training and career development workshops. Trainees have access to all resources of the Memorial Sloan-Kettering Cancer Center, an instituion in which basic, translational and clinical research activites take place in close proximity in a highly collaborative research environment. The research areas of principal emphasis include: 1) Human cancer biology, mouse models of cancer, genetics and molecular pathology; 2) Drug development and mechanism-based therapeutics; 3) Signals and pathways involved in control of cell proliferation; 4) Regulatory pathways involved in developmental biology and cell differentiation; 5) Cell-cell interactions, adhesion and protein targeting; 6) Tumor immunology, immunotherapy and transplantation biology. The Clinical Scholars Biomedical Research Training Program has had a long and successful training history with nearly all of its graduates continuing in highly productive research careers. Thus, the Program has had signficant impact in meeting the national need for physician-scientists who can play leading roles in translating basic discoveries in cancer biology into patient care.