VITAL: VIrtual Twins as tools for personalised clinicAL care

VITAL：虚拟双胞胎作为个性化临床护理的工具

• 批准号: 10106393
• 金额: $ 96.19万
• 依托单位: KING'S COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10106393
• 关键词: VITAL; VIrtual; Twins; tools; personalised

VITAL will deliver a comprehensive clinically validated multi-scale, multi-organ modelling platform that is driven by and can represent individual patient data acquired, both in the clinic and from wearable technology. The platform will create a virtual human twin for individualised and sex-specific optimisation of medical (pharmacological) orsurgical (interventional) therapy for complex, multifactorial cardiovascular disorders that have systemic impact and high risk of comorbidities of a.o. the kidney and brain: systemic hypertension, heart failure (with/without preserved ejection fraction) and hemodynamically complicated atrial septal defects.User-friendly interfaces, co-created with healthcare professionals, will provide access to the technology. The platform consolidates existing multi-scale and multi-organ models of the heart, lung and systemic circulation and their regulatory mechanisms, and advances the state-of-the art by incorporating currently missing biophysics-based, physiology-underpinned components (kidney-related blood pressure control, hormonal actions, vascular region-specific smooth muscle cell functionality, and cardiac and arterial growth and remodelling mechanobiological mechanisms). By the end of the project, the platform will have been validated and tested in more than 200 patients across 5 clinical studies in France and the UK to optimise the treatment of patients with resistant systemic hypertension, heart failure or atrial septum defects. A unique aspect of VITAL is its focus on monitoring the mental health of patients to understand their expectations and reservations towards digital health technology. VITAL technology will be compliant with and contribute directly to the VPHi and EDITH virtual twin ecosystem. This will further unlock the potential of new digital tools that intelligently combine the power of physics-based multi-scale models, artificial intelligence and data to provide better health care for all.

VITAL将提供一个全面的、经过临床验证的多尺度、多器官建模平台，该平台由临床和可穿戴技术中获得的个体患者数据驱动，并可以代表这些数据。该平台将创建一个虚拟的人类双胞胎，用于个性化和性别特异性的医学（药理学）或外科（介入）治疗复杂的多因素心血管疾病，这些疾病具有全身性影响，并有肾脏和大脑合并症的高风险：全身性高血压、心力衰竭（有/没有保留射血分数）和血流动力学复杂的房间隔缺陷。与医疗保健专业人员共同创建的用户友好界面将提供对该技术的访问。该平台整合了现有的多尺度、多器官的心脏、肺和体循环模型及其调控机制，并通过整合目前缺失的基于生物物理学、以生理学为基础的组件（肾脏相关血压控制、激素作用、血管区域特异性平滑肌细胞功能、心脏和动脉生长和重塑机械生物学机制）来推进最先进的技术。到项目结束时，该平台将在法国和英国的5项临床研究中对200多名患者进行验证和测试，以优化顽固性全身性高血压、心力衰竭或房间隔缺损患者的治疗。VITAL的一个独特之处在于，它专注于监测患者的心理健康状况，以了解他们对数字健康技术的期望和保留。VITAL技术将符合VPHi和EDITH虚拟孪生生态系统，并直接为其做出贡献。这将进一步释放新的数字工具的潜力，这些工具将基于物理的多尺度模型、人工智能和数据的力量智能地结合起来，为所有人提供更好的医疗保健。