Electroretinogram: a new human biomarker for smoking cessation treatment

视网膜电图：戒烟治疗的新人类生物标志物

基本信息

批准号：
10180928
负责人：
Sean Xiao Luo
金额：
$ 19.98万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10180928
关键词：
Abstinence Address Alcohol consumption Amacrine Cells Animal Experiments Area Attention deficit hyperactivity disorder Behavior Therapy Biological Markers Brain Clinical Clinical Research Clinical Trials Cocaine Users Collaborations Cone Corpus striatum structure Data Data Analytics Development Diagnosis Disease Dopamine Dopamine D1 Receptor Dopamine D2 Receptor Dose Early treatment Electroretinography Exhibits Funding Future Gold Grant Human Incentives Individual Knowledge Light Maintenance Measures Medicine Mental disorders Mentored Patient-Oriented Research Career Development Award Mentors Neurotransmitters Nicotine Dependence Oral Participant Patients Pharmacological Treatment Pharmacology Physiology Positron-Emission Tomography Prediction of Response to Therapy Protocols documentation Proxy Public Health Records Research Research Methodology Research Personnel Retina Rewards Ritalin Secure Severities Signal Transduction Smoker Smoking Cessation Intervention Substance Use Disorder Symptoms Techniques Testing Tobacco Use Disorder Tobacco smoking behavior Tobacco use Training Programs Variant Ventral Striatum Writing addiction analytical method base biomarker development career cigarette smoking cocaine use contingency management cost effectiveness craving financial incentive genetic manipulation global health individual patient individual variation neuromechanism neurotransmission non-smoking opioid use outcome prediction programs psychostimulant recruit response smoking cessation substance use treatment treatment response

项目摘要

Project Title: Electroretinogram: A New Human Biomarker for Smoking Cessation Treatment Project Summary: In this application for a K23 Mentored Patient Oriented Research Career Development Award, Dr. Sean Luo proposes a comprehensive plan for developing into an independent researcher to develop biomarkers in substance use disorders, and in particular, tobacco use disorder. Specifically, this proposal will focus on developing a new human biomarker, electroretinogram, for dopamine release. Tobacco smoking continues to be a major public health challenge. Several lines of evidence suggest that dopamine release deficit is involved in the development and maintenance of nicotine dependence. We hypothesize that those smokers who do not have a deficit in dopamine release will more likely respond to behavioral treatments for smoking cessation, and in particular, financial incentives contingent on abstinence (Contingency Management). Previous pilot data suggest that flash blue cone electroretinogram (ERG), which records electrical signals from the retina in response to light, is a clinically accessible correlate to dopamine release in the brain. We propose an ERG-based biomarker, and a pilot clinical trial to apply this biomarker to personalize smoking cessation treatment. This clinically tractable biomarker of central dopamine release may have a large number of future applications in the diagnosis and treatment of other mental illnesses and substance use disorders. While pursuing this line of research with the expertise of his mentors (Dr. Edward Nunes and Dr. Frances Levin) and preceptors (Drs. Diana Martinez, Stephen Tsang, Alan Budney and Jill Williams), Dr. Luo will concurrently engage in an individualized training program so as to develop in the following important areas: (1) retinal physiology and biomarker development (2) retinal data analytic methods (3) clinical research methods (4) behavioral and pharmacological treatment of tobacco use disorder (5) grant writing and administration.

项目名称：电视图：一种新的人类生物标志物，用于戒烟治疗项目摘要：在此申请中，K23指导了以患者为导向的研究职业发展奖项，肖恩·卢（Sean Luo）博士提出了一项综合计划，以发展为独立研究人员开发在药物使用障碍的生物标志物，尤其是烟草使用障碍。具体来说，这是提案将着重于开发一种新的人类生物标志物电视图，以释放多巴胺。烟草吸烟仍然是一个主要的公共卫生挑战。几条证据表明多巴胺释放赤字涉及尼古丁依赖性的发展和维持。我们假设这一点那些没有多巴胺释放不足的吸烟者会更有可能对行为治疗做出反应为了戒烟，尤其是戒酒的经济激励措施（意外事件）管理）。以前的飞行员数据表明闪电蓝锥电子图（ERG），该图记录来自视网膜的电信号响应光，是在临床上与多巴胺释放相关的大脑。我们提出了一个基于ERG的生物标志物，并进行了一项试验临床试验，以应用此生物标志物来个性化戒烟治疗。这种临床上可拖动的中央多巴胺释放的生物标志物可能具有较大的未来在诊断和治疗其他精神疾病和药物使用方面的应用数量疾病。在他的导师的专业知识（Edward Nunes博士和博士）的同时，进行了这一研究。弗朗西斯·莱文（Frances Levin））和受体（Diana Martinez博士，Stephen Tsang，Alan Budney和Jill Williams），Luo博士将同时参与个性化的培训计划，以在以下重要领域发展：（1）视网膜生理学和生物标志物发育（2）视网膜数据分析方法（3）临床研究方法（4）烟草使用障碍的行为和药理治疗（5）授予写作和行政。