Fast deployed mobile laboratories to enhance situational awareness for pandemics and emerging infectious diseases: ONELAB

来自世界各地的专家意见建议并呼吁为疾病监测任务提供模块化实验室系统。世卫组织称这些实验室为“快速反应移动实验室”（RRML）。ONELAB将开发模块化RRML，用于快速、灵活、可扩展、多场景的部署，以实现最广泛的可能设置。这些下一代设施将支持下一代测量技术/方法，并通过卫星通信形成广域GIS实验室信息系统。因此，同时提供定点疾病检测，以及高水平的态势感知。ONELAB还将为分期疾病检测反应开发先进的测量系统。利用一组急性病毒感染生物标志物可以在无症状潜伏期早期发现疾病。在疾病暴发时使用这种方法，在许多方面仍未确定的情况下，可支持有效和有针对性的即时公共卫生干预措施。此外，利用为应对COVID - 19而开发的成熟方法，ONELAB将开发和演示半自主疾病特异性生物标志物发现的工作流程。敏捷科学的这种应用和交付增强了当前疾病测试策略的能力和能力——实质上，rrml只与操作它们的熟练团队一样好。因此，ONELAB建立了由经验丰富的专家组成的全球网络和合作伙伴关系，以：定义符合具体情况的最佳实践；形成以共识为导向的经营理念；并通过大流行测试手册传播这一点。我们将通过在项目结束后继续进行的培训和网络活动来发展能力和能力。最后，社区大规模测试需要所有公民的参与和接受，这就是为什么我们将与公众接触，并在教育外展资源的支持下制作一份大规模社区测试的公民指南。

Expert opinion from across the world recommends, & calls for, modular laboratory systems to be made available for disease monitoring missions. The WHO calls these, “Rapid Response Mobile Laboratories” (RRML). ONELAB will develop modular RRML for rapid, flexible, scalable, multi-scenario deployments into the widest range of possible settings. These next-generation facilities will support next generation measurement-technologies/methodologies and, through satellite communications, form wide-area GIS enabled laboratory information systems. Thus, simultaneously providing point-of-need disease detection, along with high-level situational awareness. ONELAB will also develop advanced measurement systems for a staged disease detection response. Exploiting a panel of acute viral infection biomarkers enables early detection of disease during its asymptomatic incubation. Using this at the outbreak of disease, when much is still undefined, supports effective immediate & targeted public health interventions. Additionally, using proven methodologies developed in response to COVID 19, ONELAB will develop & demonstrate a workflow for semi-autonomous disease specific biomarker discovery. This application & delivery of agile science enhances the capability & capacity of current disease testing-strategies substantially RRMLs are only as good as the skilled teams who operate them. So, ONELAB builds world-wide networks & partnerships of experienced experts to: define contextually-aligned best practice; develop a consensus-driven concepts of operation; and, disseminate this though a pandemic testing playbook. We will develop capability & capacity with training & networking-events that continue beyond the project. Finally, community mass-testing requires engagement & acceptance from all citizens, which is why we will engage with the public, & produce a citizen’s guide to mass community testing, supported by educational outreach resources.