Fast deployed mobile laboratories to enhance situational awareness for pandemics and emerging infectious diseases: ONELAB

来自世界各地的专家建议并呼吁为疾病监测任务提供模块化实验室系统。世界卫生组织称之为“快速反应移动的实验室”。ONELAB将开发模块化RRML，用于快速，灵活，可扩展，多场景部署到最广泛的可能设置中。这些下一代设施将支持下一代测量技术/方法，并通过卫星通信，形成广域GIS实验室信息系统。因此，沿着高水平的情境感知，同时提供即时疾病检测。ONELAB还将开发先进的测量系统，用于分阶段的疾病检测反应。利用一组急性病毒感染生物标志物能够在无症状潜伏期内早期检测疾病。在疾病爆发时，当许多情况仍然不确定时，利用这一点可以支持有效的立即和有针对性的公共卫生干预措施。此外，ONELAB将使用为应对COVID 19而开发的成熟方法，开发并演示半自主疾病特异性生物标志物发现的工作流程。这种敏捷科学的应用和交付增强了当前疾病测试策略的能力，而RRML的有效性取决于操作它们的熟练团队。因此，ONELAB建立了经验丰富的专家的全球网络和合作伙伴关系：定义与背景一致的最佳实践;制定共识驱动的操作概念;并通过流行病测试剧本传播。我们将通过培训和网络活动来发展能力和能力，这些活动将持续到项目之后。最后，社区大规模测试需要所有公民的参与和接受，这就是为什么我们将与公众接触，并制作一个公民指南，以大规模社区测试，由教育推广资源的支持。

Expert opinion from across the world recommends, & calls for, modular laboratory systems to be made available for disease monitoring missions. The WHO calls these, “Rapid Response Mobile Laboratories” (RRML). ONELAB will develop modular RRML for rapid, flexible, scalable, multi-scenario deployments into the widest range of possible settings. These next-generation facilities will support next generation measurement-technologies/methodologies and, through satellite communications, form wide-area GIS enabled laboratory information systems. Thus, simultaneously providing point-of-need disease detection, along with high-level situational awareness. ONELAB will also develop advanced measurement systems for a staged disease detection response. Exploiting a panel of acute viral infection biomarkers enables early detection of disease during its asymptomatic incubation. Using this at the outbreak of disease, when much is still undefined, supports effective immediate & targeted public health interventions. Additionally, using proven methodologies developed in response to COVID 19, ONELAB will develop & demonstrate a workflow for semi-autonomous disease specific biomarker discovery. This application & delivery of agile science enhances the capability & capacity of current disease testing-strategies substantially RRMLs are only as good as the skilled teams who operate them. So, ONELAB builds world-wide networks & partnerships of experienced experts to: define contextually-aligned best practice; develop a consensus-driven concepts of operation; and, disseminate this though a pandemic testing playbook. We will develop capability & capacity with training & networking-events that continue beyond the project. Finally, community mass-testing requires engagement & acceptance from all citizens, which is why we will engage with the public, & produce a citizen’s guide to mass community testing, supported by educational outreach resources.