Fast deployed mobile laboratories to enhance situational awareness for pandemics and emerging infectious diseases: ONELAB

来自世界各地的专家意见建议并呼吁为疾病监测任务提供模块化的实验室系统。世界卫生组织将其称为“快速反应移动实验室”(RRML)。ONELAB将开发模块化RRML，以便在最广泛的环境中进行快速、灵活、可扩展的多场景部署。这些下一代设施将支持下一代测量技术/方法，并通过卫星通信形成广域地理信息系统支持的实验室信息系统。因此，同时提供需要点疾病检测，以及高级别的情况感知。ONELAB还将开发用于阶段性疾病检测响应的先进测量系统。利用一组急性病毒感染生物标志物，可以在疾病无症状潜伏期间及早发现疾病。在疾病暴发时使用它，在许多方面仍未确定时，支持有效的、立即的和有针对性的公共卫生干预。此外，使用针对COVID 19开发的成熟方法，ONELAB将开发和演示半自主疾病特定生物标记物发现的工作流程。这种敏捷科学的应用和交付增强了当前疾病检测的能力和能力--RRML的战略实质上取决于操作它们的熟练团队。因此，ONELAB建立了由经验丰富的专家组成的全球网络和伙伴关系，以：定义与背景一致的最佳实践；制定以共识为导向的运营概念；并通过大流行测试手册传播这一点。我们将通过培训和网络活动发展能力和能力-这些活动将在项目之后继续下去。最后，社区大规模测试需要所有公民的参与和接受，这就是为什么我们将与公众接触，并在教育外展资源的支持下制作一份公民指南。

Expert opinion from across the world recommends, & calls for, modular laboratory systems to be made available for disease monitoring missions. The WHO calls these, “Rapid Response Mobile Laboratories” (RRML). ONELAB will develop modular RRML for rapid, flexible, scalable, multi-scenario deployments into the widest range of possible settings. These next-generation facilities will support next generation measurement-technologies/methodologies and, through satellite communications, form wide-area GIS enabled laboratory information systems. Thus, simultaneously providing point-of-need disease detection, along with high-level situational awareness. ONELAB will also develop advanced measurement systems for a staged disease detection response. Exploiting a panel of acute viral infection biomarkers enables early detection of disease during its asymptomatic incubation. Using this at the outbreak of disease, when much is still undefined, supports effective immediate & targeted public health interventions. Additionally, using proven methodologies developed in response to COVID 19, ONELAB will develop & demonstrate a workflow for semi-autonomous disease specific biomarker discovery. This application & delivery of agile science enhances the capability & capacity of current disease testing-strategies substantially RRMLs are only as good as the skilled teams who operate them. So, ONELAB builds world-wide networks & partnerships of experienced experts to: define contextually-aligned best practice; develop a consensus-driven concepts of operation; and, disseminate this though a pandemic testing playbook. We will develop capability & capacity with training & networking-events that continue beyond the project. Finally, community mass-testing requires engagement & acceptance from all citizens, which is why we will engage with the public, & produce a citizen’s guide to mass community testing, supported by educational outreach resources.