Risk and Resilience in Developmental Diversity and Mental Health (R2D2-MH)

患有精神健康（MH）疾病的个人及其家人，特别是那些患有高度流行的神经发育障碍（NDD）的人，面临着高度的歧视和耻辱，这严重影响了他们的身心健康。我们在NDD研究前沿的世界领先的合作小组将启动一个新的项目-？心理健康中的风险、复原力和发展多样性？（R2 D2-MH）。我们提出了一个双重的范式转变，以改善MH条件的人及其家庭的福祉。我们将（i）从以风险为重点的研究转向理解和促进复原力，以及（ii）从基于诊断的方法转向发展多样性方法，该方法将定义整个人类生命周期的福祉和功能。R2D2- MH旨在确定遗传和环境保护/恢复力因素以及它们如何影响发育多样性和MH。我们将在多个层面调查两个高度流行的早期风险MH条件：早产和遗传责任的NDD。我们的项目有四个主要目标1.提供欧洲最大的关于早期人类大脑发育和MH结果的多尺度数据集; 2确定对NDD不利影响的恢复力的生物学机制; 3.与利益攸关方共同开发新的数字化工具，以增加参与性研究/医学并减少污名化; 4.建立预测模型以指导个性化干预。R2D2-MH整合了欧洲，以色列和澳大利亚的跨学科和互补专业知识，涵盖伦理学，流行病学，社会学，遗传学，细胞生物学，神经科学，计算建模，信息技术，心理学和精神病学。我们的研究是高度参与：它嵌入参与者和患者参与研究，以确保我们的预期结果是真正的翻译，并将有助于减少耻辱和负担的个人与MH条件。

Individuals with mental health (MH) conditions and their families, especially those with highly prevalent neurodevelopmental disorders (NDDs), are exposed to high levels of discrimination and stigma, which significantly affects their physical and mental well-being. Our world-leading collaborative group at the forefront of research in NDDs will launch a new project - ?Risk, Resilience and Developmental Diversity in Mental Health? (R2D2-MH). We propose a double paradigm shift to improve the wellbeing of people with MH conditions and their families. We will move (i) from risk-focused studies towards understanding and promoting resilience, and (ii) from a diagnosis based approach to a developmental diversity approach that will define wellbeing and functioning across the human lifespan. R2D2- MH aims to identify genetic and environmental protective/resilience factors and how they influence developmental diversity and MH. We will investigate at multiple levels two highly prevalent early risks for MH conditions: prematurity and genetic liability for NDDs. Our project has four main ambitions 1. Provide the largest European multi-scale dataset on early human brain development and MH outcomes; 2 Identify biological mechanisms of resilience to the adverse effects of NDD; 3. Co-develop, with the stakeholders, new digital tools to increase participatory research/medicine and reduce stigma; 4. Establish predictive models to guide personalised interventions. R2D2-MH integratesinterdisciplinary and complementary expertise across Europe, Israel, and Australia that covers ethics, epidemiology, sociology, genetics, cell biology, neuroscience, computational modelling, Information Technology, psychology, and psychiatry. Our research is highly engaged: it embeds participant and patient involvement in research to ensure that our expected outcomes are truly translational, and will help to reduce stigma and burden for individuals with MH conditions.