MIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C Program

MIS-C 计划：儿科心脏网络 MIS-C 计划数据协调中心

• 批准号: 10202823
• 负责人: Julie Elaine Miller
• 金额: $ 432.76万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-04 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202823
• 关键词: 2019-nCoV; Address; Agreement; Budgets; COVID-19; Childhood; Clinical Trials Data Monitoring Committees; Cohort Studies; Data; Data Coordinating Center; Development; Electrocardiogram; Goals; Heart; Individual; Information Dissemination; Infrastructure; Knowledge; Laboratories; Leadership; Link; Logistics; Longterm Follow-up; Magnetic Resonance Imaging; Maintenance; Methods; Monitor; National Heart, Lung, and Blood Institute; Natural History; Outcome; Participant; Periodicity; Phenotype; Progress Reports; Protocols documentation; Research; Review Committee; Running; Services; Site; System; TimeLine; United States National Institutes of Health; Update; Work; cloud based; data integration; electronic data capture system; insurance claims; operation; payment; programs; recruit; social media; symposium; trial design; web site; webinar

PROJECT SUMMARY/ABSTRACT To address the knowledge gap discussed previously, NIH is initiating a national research program focused on pediatric SARS-CoV-2, COVID-19 and MIS-C. This goal of the program is to gain comprehensive understanding of phenotype, natural history, outcomes, and pathobiology of MIS-C. The Program will have several components including a MIS-C Cohort Study, adaptive design trials, long-term follow-up and a robust cloud-based data platform. The PHN DCC will serve to coordinate some of the components of the Program. The Specific Aims of the DCC are as follows: AIM 1: MANAGE CORE PROGRAM OPERATIONS AIM 2: MANAGE MIS-C COHORT STUDY DEVELOPMENT, LAUNCH, AND DISSEMINATION OF RESULTS AIM 3: PROVIDE SUPPORT SERVICES TO PROGRAM COMPONENTS

项目总结/摘要 为了解决前面讨论的知识差距，NIH正在启动一项国家研究计划，重点是 儿科SARS-CoV-2、COVID-19和MIS-C。该计划的目标是获得全面的 了解MIS-C的表型、自然史、结局和病理生物学。该方案将有 几个组成部分，包括MIS-C队列研究，适应性设计试验，长期随访和稳健的 基于云的数据平台菲律宾发展协调委员会将负责协调该方案的一些组成部分。 发展协调委员会的具体目标如下： 目标1：管理核心业务 目标2：管理MIS-C队列研究的开发、启动和传播 结果 目标3：向可持续发展组成部分提供支助服务