CC16 in Childhood and Resilience to Persistent Asthma into Adult Life (Supplement)
CC16 in Childhood and Resilience to Persistent Asthma into Adult Life (Supplement)
批准号:
10189106
负责人:
Stefano Guerra
金额:
$14.92万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-07-06 至 2021-08-31
关键词:
2019-nCoVAcademic Medical CentersAddressAdhesionsAdultAdult Respiratory Distress SyndromeAffectAgeAmbulatory Care FacilitiesAnti-Inflammatory AgentsArizonaAsthmaBloodBlood CirculationCOVID-19CellsChildhoodClinicalClinical DataColonoscopyControl GroupsDataDevelopmentDiseaseDisease ProgressionDistalEmployee HealthEndothelial CellsFrequenciesFundingGenesGoalsHealth PersonnelHospitalizationImmune responseIndividualInfectionInfiltrationInflammationInflammatoryInflammatory ResponseInpatientsLeukocytesLifeLungLung infectionsMeasuresMedicalMolecularOutpatientsParticipantPathway interactionsPatientsPeptidyl-Dipeptidase APilot ProjectsPlayPopulationPredispositionProceduresProductionPropertyProteinsProteomicsReportingRhinovirusRisk stratificationRoleSamplingScheduleSecretory CellSeverity of illnessSwabSymptomsTestingTimeViralVirusantimicrobialbasecase controlcell typecoronavirus diseasecostinsightinterestmetabolomicsnovelpandemic diseaseparent grantpreventprospectiveprotective effectreceptorrecruitresilienceresponsescreeningsecretory proteinsex
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
In response to NOT-AI-20-031 [“Notice of Special Interest: Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)”] and in line with the scope of the parent grant, the
goal of this supplement is to determine the role of Club cell secretory protein (CC16) in providing
resilience to COVID-19. CC16 is a homodimeric pneumoprotein that is encoded by the SCGB1A1 gene,
mainly produced by Club cells in the distal airways, and readily measured in circulation.
The central hypothesis of our parent grant is that CC16 exerts protective effects in the lungs by modulating
susceptibility and inflammatory responses to airway infections. In addition, because CC16-secreting Club cells
are among the main airway cell types expressing Angiotensin-Converting Enzyme 2 (ACE2), it is plausible that
– by infecting Club cells – SARS-CoV-2 can affect their survival and/or secretory machinery, and in turn impact
production of CC16. Here, we postulate that CC16 plays a critical role in susceptibility and host inflammatory
responses to SARS-CoV-2 and propose the following specific aim:
Specific Aim - To determine the relation of circulating CC16 to the presence and clinical progression of
COVID-19.
In this pilot study, we will collect clinical data and biospecimens from both inpatients and outpatients with
COVID-19 at Banner University Medical Center – Tucson. Depending on the dynamics of the pandemic, we
estimate that we will recruit between 75-125 inpatients and 100-200 outpatients. In addition, we will recruit a
group of controls (with a target case:control ratio of 2:1). Data from these participants will be used to compare
circulating levels of CC16 across the three groups of controls, COVID-19 outpatients, and COVID-19
inpatients. In addition, circulating deficits of CC16 will be tested for prediction of subsequent clinical
progression of disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CC16 in Childhood and Resilience to Persistent Asthma into Adult Life
-
批准号:10224859
-
项目类别:
-
资助金额:$72.3万
-
财政年份:2017
-
负责人:Stefano Guerra
-
依托单位:
CC16 in Childhood and Resilience to Persistent Asthma into Adult Life
-
批准号:9426640
-
项目类别:
-
资助金额:$72.76万
-
财政年份:2017
-
负责人:Stefano Guerra
-
依托单位:
Early Origins of Chronic Lung Disease: Outcomes into the Fifth Decade of Life
-
批准号:10610445
-
项目类别:
-
资助金额:$151.98万
-
财政年份:2016
-
负责人:Stefano Guerra
-
依托单位:
Early Origins of Chronic Airflow Limitation: Outcomes Into the 4th Decade of Life
-
批准号:9455772
-
项目类别:
-
资助金额:$137.64万
-
财政年份:2016
-
负责人:Stefano Guerra
-
依托单位:
Early Origins of Chronic Lung Disease: Outcomes into the Fifth Decade of Life
-
批准号:10405444
-
项目类别:
-
资助金额:$151.8万
-
财政年份:2016
-
负责人:Stefano Guerra
-
依托单位:
Validation of serum biomarker signatures predictive of incident COPD
-
批准号:8262689
-
项目类别:
-
资助金额:$44.88万
-
财政年份:2011
-
负责人:Stefano Guerra
-
依托单位:
Validation of serum biomarker signatures predictive of incident COPD
-
批准号:8073770
-
项目类别:
-
资助金额:$45.71万
-
财政年份:2011
-
负责人:Stefano Guerra
-
依托单位:
Serum Biomarkers of COPD: a population-based prospective study
-
批准号:8431380
-
项目类别:
-
资助金额:$35.7万
-
财政年份:2009
-
负责人:Stefano Guerra
-
依托单位:
Serum Biomarkers of COPD: a population-based prospective study
-
批准号:7573285
-
项目类别:
-
资助金额:$37.75万
-
财政年份:2009
-
负责人:Stefano Guerra
-
依托单位:
Serum Biomarkers of COPD: a population-based prospective study
-
批准号:8217147
-
项目类别:
-
资助金额:$37.5万
-
财政年份:2009
-
负责人:Stefano Guerra
-
依托单位:
Serum Biomarkers of COPD: a population-based prospective study
-
批准号:8021003
-
项目类别:
-
资助金额:$37.88万
-
财政年份:2009
-
负责人:Stefano Guerra
-
依托单位:
Serum Biomarkers of COPD: a population-based prospective study
-
批准号:7760635
-
项目类别:
-
资助金额:$37.82万
-
财政年份:2009
-
负责人:Stefano Guerra
-
依托单位:
Serum Biomarkers of COPD: a population-based prospective study
-
批准号:7842891
-
项目类别:
-
资助金额:$17.66万
-
财政年份:2009
-
负责人:Stefano Guerra
-
依托单位:
Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and Morality
-
批准号:7129518
-
项目类别:
-
资助金额:$15.1万
-
财政年份:2006
-
负责人:Stefano Guerra
-
依托单位:
Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and Morality
-
批准号:7268137
-
项目类别:
-
资助金额:$14.66万
-
财政年份:2006
-
负责人:Stefano Guerra
-
依托单位:
Childhood Predictors of Airway Structure, Function, and Disease in Adult Life
-
批准号:8319856
-
项目类别:
-
资助金额:$110.84万
-
财政年份:1996
-
负责人:Stefano Guerra
-
依托单位:
Childhood Predictors of Airway Structure, Function, and Disease in Adult Life
-
批准号:8441514
-
项目类别:
-
资助金额:$105.39万
-
财政年份:1996
-
负责人:Stefano Guerra
-
依托单位:
海外基金