Allergen Exposure Reduction as a Disease-Modifying Strategy in Allergen-Sensitized Children with Asthma

项目摘要/总结： Torie Grant，医学博士，MHS是约翰霍普金斯大学儿科和医学助理教授 医学院。格兰特博士寻求K23指导的以患者为导向的研究职业发展奖 为了获得技能，知识和指导的研究经验，这是必要的基础， 职业生涯作为一个独立的临床研究人员研究成人肺部疾病的儿科决定因素。博士 格兰特的职业发展计划包括在约翰霍普金斯大学攻读流行病学博士学位 彭博公共卫生学院。她的导师团队包括知名的医生科学家， 数十年的研究和指导经验：罗伯特·伍德博士（联合小学导师）拥有超过30年的 儿科哮喘研究和指导经验; Elizabeth Matsui博士（共同主要导师）一直是 多项儿童哮喘研究的PI，重点关注环境暴露; Robert Wise博士是 肺功能测试和哮喘临床试验; Corinne Keet博士是哮喘流行病学专家 以及哮喘和过敏性疾病的环境风险;艾伦埃弗雷特博士是生物标志物发现方面的专家; 罗杰·彭博士是一位环境生物统计学家，在环境暴露和健康方面具有专长。 成果。 目前的儿童哮喘治疗在实现哮喘控制方面是有效的，但对哮喘患者的治疗效果甚微。 哮喘进展到成年。新出现的证据表明，室内过敏原暴露可能 过敏原致敏儿童从童年到成年对肺功能的有害影响 哮喘本提案的目标1旨在研究室内过敏原暴露的长期影响， 致敏对肺功能发育和成人阻塞性肺病风险的影响。目标2将检验 减少室内变应原暴露对肺功能的影响。目标3将探讨 室内过敏原暴露减少和肺纤维化和重塑的假设驱动的生物标志物。 这些目标将为我们理解室内过敏原暴露在肺中的作用增加重要的知识。 功能增长，概念化过敏原减少作为一种疾病修饰疗法。格兰特博士的背景 她是一名内科医生、儿科医生和过敏症免疫学家，受过流行病学和生物统计学方面的培训， 研究儿童哮喘成人肺功能结局的理想候选者。

PROJECT ABSTRACT/SUMMARY: Torie Grant, MD, MHS is an Assistant Professor of Pediatrics and Medicine at Johns Hopkins University School of Medicine. Dr. Grant seeks a K23 Mentored Patient-Oriented Research Career Development Award in order to obtain the skills, knowledge, and mentored research experience that are the essential foundation for a career as an independent clinical investigator studying pediatric determinants of adult lung disease. Dr. Grant's career development plan includes the pursuit of a PhD in epidemiology at the Johns Hopkins Bloomberg School of Public Health. Her mentorship team includes established physician scientists with decades of research and mentorship experience: Dr. Robert Wood (co-primary mentor) has over 30 years of pediatric asthma research and mentoring experience; Dr. Elizabeth Matsui (co-primary mentor) has been the PI of multiple pediatric asthma studies focusing on environmental exposures; Dr. Robert Wise is an expert in pulmonary function testing and asthma clinical trialist; Dr. Corinne Keet is an expert is asthma epidemiology and environmental risks for asthma and allergic diseases; Dr. Allen Everett is an expert in biomarker discovery; and Dr. Roger Peng is an environmental biostatistician with expertise in environmental exposures and health outcomes. Current pediatric asthma therapies are effective in achieving asthma control, but have little effect on the progression of asthma into adulthood. Emerging evidence suggests that indoor allergen exposure may have deleterious effects on lung function trajectory from childhood to adulthood among allergen-sensitized children with asthma. Aim 1 of this proposal seeks to examine the long-term effects of indoor allergen exposure and sensitization on lung function growth and risk of adult obstructive lung disease. Aim 2 will examine the effects of indoor allergen exposure reduction on lung function growth. Aim 3 will explore the relationship between indoor allergen exposure reduction and hypothesis-driven biomarkers of pulmonary fibrosis and remodeling. These aims will add critical knowledge to our understanding of the role of indoor allergen exposure in lung function growth, conceptualizing allergen reduction as a disease-modifying therapy. Dr. Grant's background as an internist, pediatrician, and allergist-immunologist, with training in epidemiology and biostatistics, makes her the ideal candidate to study adult lung function outcomes in pediatric asthma.