Epidemiologic and Translational Investigation of Long-Term Kidney Outcomes After COVID-19
COVID-19 后长期肾脏结局的流行病学和转化调查
基本信息
- 批准号:10190314
- 负责人:
- 金额:$ 19.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAPOL1 geneAcuteAcute Renal Failure with Renal Papillary NecrosisAffectAlbuminuriaAwardBiological MarkersBloodCCL2 geneCOVID-19COVID-19 diagnosisCOVID-19 patientClinicalComplicationComputerized Medical RecordCountryCreatinineDataDiagnosisDoctor of PhilosophyEpidemiologyEvaluationEventFive-Year PlansFoundationsFundingGoalsHealthHealth systemHigh PrevalenceHospital MortalityHospitalizationHospitalsIL8 geneIncidenceInflammationInflammatoryInjuryInjury to KidneyInterleukin-1 betaInterleukin-10Interleukin-18Interleukin-2Interleukin-4Interleukin-6InvestigationKidneyKnowledgeLCN2 geneLettersMeasurementMeasuresMedicineMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMethodsMorbidity - disease rateNatural HistoryNatureNephrologyOutcomePatientsPatternPhenotypePhysiciansPremature MortalityPrevalenceProcessPrognosisProtocols documentationPublic Health SchoolsRaceRecording of previous eventsRegistriesRenal functionResearchResearch DesignResearch PersonnelResearch Project GrantsSARS-CoV-2 infectionSamplingScientistSerumSurvivorsTNF geneTimeTrainingTraining and EducationTubular formationUMOD geneUniversitiesUrineViralWorkadjudicateanalytical methodcareercohortexperiencefollow-upfunctional declinehigh riskinsightinstructormedical schoolsmortalitymultiplex assaynovel coronaviruspandemic diseasepreventprofessorrecruitresearch studyrisk variantsex
项目摘要
PROJECT SUMMARY/ABSTRACT
Candidate
Steven Menez, MD, MHS, is an Instructor of Medicine in the Division of Nephrology at Johns Hopkins
University School of Medicine, who will be promoted to Assistant Professor of Medicine on July 1, 2020. He
seeks a K23 Mentored Patient-Oriented Research Career Development Award in order to develop and execute
his proposed research project aimed at investigating the long-term kidney outcomes in hospitalized patients
diagnosed with the novel Coronavirus Disease 2019 (COVID-19) surviving to discharge. This proposal
additionally details a five-year plan consisting of advanced training in analytic methods and research study
design, as well as mentorship by Chirag Parikh, MD, PhD, and Morgan Grams, MD, PhD. Dr. Menez’s
immediate career goals include the investigation of kidney injury and inflammation phenotypes in hospitalized
patients with COVID-19 surviving to discharge and the evaluation of long-term kidney outcomes and mortality
in COVID-19 hospitalization survivors. His long-term goal is to become an independent physician-scientist
specializing in translational AKI research, with a specific focus on preventing the progression of CKD after AKI,
in particular viral-associated AKI. Throughout this award process he will enrich his education and training
through additional classes at the Johns Hopkins Bloomberg School of Public Health, in addition to working
closely with his team of mentors and advisors. Dr. Menez’s proposed work will help in his transition to an R01-
funded independent investigator.
Project
Over 6 million people worldwide have been diagnosed with COVID-19.1,2 Acute kidney injury (AKI) is a frequent
complication in hospitalizations for COVID-19, which has been associated with poor short-term outcomes,
including in-hospital mortality.3,4 The goals of this proposal are to investigate the prevalence of elevated
albuminuria and other biomarkers of kidney injury and inflammation at 3 months post-discharge in 250 patients
with COVID-19 surviving hospitalization, and to associate these markers with kidney function decline and
mortality at 24 months. This study will also quantify changes in kidney function over time in a larger cohort of
all patients in the Johns Hopkins Health System admitted with COVID-19 (N~2000). The candidate
hypothesizes that patients hospitalized with COVID-19 who develop clinical AKI and survive to discharge will
have significantly greater albuminuria and higher levels of biomarkers of kidney injury and inflammation at 3
months post-discharge, and these phenotypes will associate with worse kidney outcomes and mortality up to
24 months. Further, he hypothesizes that patients with clinical AKI in the hospital will have worse kidney
function decline and higher mortality at 24 months than patients without clinical AKI.
项目摘要/摘要
侯选人
史蒂文·梅内兹,医学博士,MHS,约翰霍普金斯大学肾脏病学部医学讲师
他将于2020年7月1日晋升为医学助理教授。他
寻求K23导师以患者为导向的研究职业发展奖,以开发和执行
他提出的研究项目旨在调查住院患者的长期肾脏结果。
被诊断出患有新型冠状病毒病2019年(新冠肺炎),存活出院。这项建议
此外,还详细介绍了由分析方法高级培训和研究性学习组成的五年计划
设计,以及Chirag Parikh医学博士和Morgan Grams医学博士的指导。梅内兹医生的
近期职业目标包括调查住院患者的肾脏损伤和炎症表型。
新冠肺炎患者出院后存活及远期肾脏结局和死亡率的评估
在新冠肺炎住院的幸存者。他的长期目标是成为一名独立的内科医生-科学家
专门从事翻译AKI研究,特别关注预防AKI后CKD的进展,
尤其是与病毒相关的AKI。在整个颁奖过程中,他将丰富自己的教育和培训
通过约翰霍普金斯大学彭博公共卫生学院的额外课程,除了工作
与他的导师和顾问团队密切合作。梅内斯博士提议的工作将有助于他过渡到R01-
资助独立调查员。
项目
全球已有600多万人被诊断为COVID-19.1,2急性肾损伤(AKI)是一种常见的疾病
新冠肺炎患者的住院并发症一直与不良的短期结果有关,
包括住院死亡率。3,4这项提议的目标是调查高血压病的患病率
250例患者出院后3个月蛋白尿及其他肾脏损伤和炎症标志物
新冠肺炎患者在住院期间存活,并将这些标志物与肾功能下降和
死亡率为24个月。这项研究还将量化肾功能随时间的变化。
所有住在约翰霍普金斯卫生系统的患者均接受新冠肺炎治疗(2000年1月)。候选人
假设新冠肺炎患者在住院期间出现临床急性KI并存活至出院
在3岁时有显著更多的蛋白尿和更高水平的肾脏损伤和炎症的生物标志物
出院后几个月,这些表型将与更差的肾脏结果和死亡率相关,最高可达
24个月。此外,他还假设,在医院接受临床AKI治疗的患者肾脏会更差。
24个月时的功能下降和死亡率高于无临床AKI的患者。
项目成果
期刊论文数量(0)
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Steven Menez其他文献
Steven Menez的其他文献
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{{ truncateString('Steven Menez', 18)}}的其他基金
Epidemiologic and Translational Investigation of Long-Term Kidney Outcomes After COVID-19
COVID-19 后长期肾脏结局的流行病学和转化调查
- 批准号:
10378162 - 财政年份:2021
- 资助金额:
$ 19.97万 - 项目类别:
Epidemiologic and Translational Investigation of Long-Term Kidney Outcomes After COVID-19
COVID-19 后长期肾脏结局的流行病学和转化调查
- 批准号:
10543194 - 财政年份:2021
- 资助金额:
$ 19.97万 - 项目类别: