Epidemiologic and Translational Investigation of Long-Term Kidney Outcomes After COVID-19

COVID-19 后长期肾脏结局的流行病学和转化调查

• 批准号: 10378162
• 负责人: Steven Menez
• 金额: $ 19.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378162
• 关键词: 2019-nCoV; APOL1 gene; Acute; Acute Renal Failure with Renal Papillary Necrosis; Albuminuria; Award; Biological Markers; Blood; CCL2 gene; COVID-19; COVID-19 diagnosis; COVID-19 disparity; COVID-19 impact; COVID-19 patient; COVID-19 survivors; Clinical; Complication; Computerized Medical Record; Country; Creatinine; Data; Diagnosis; Doctor of Philosophy; Epidemiology; Evaluation; Event; Five-Year Plans; Foundations; Funding; Goals; Health; Health system; High Prevalence; Hospital Mortality; Hospitalization; Hospitals; IL8 gene; Incidence; Inflammation; Inflammatory; Injury; Injury to Kidney; Interleukin-1 beta; Interleukin-10; Interleukin-18; Interleukin-2; Interleukin-4; Interleukin-6; Investigation; Kidney; Knowledge; LCN2 gene; Letters; Measurement; Measures; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Morbidity - disease rate; Natural History; Nature; Nephrology; Outcome; Patients; Pattern; Persons; Phenotype; Physicians; Premature Mortality; Prevalence; Process; Prognosis; Protocols documentation; Public Health Schools; Race; Recording of previous events; Registries; Renal function; Research; Research Design; Research Personnel; Research Project Grants; SARS-CoV-2 infection; Sampling; Scientist; Serum; Survivors; TNF gene; Time; Training; Training and Education; Tubular formation; UMOD gene; Universities; Urine; Viral; Work; adjudicate; analytical method; career; cohort; experience; follow-up; functional decline; high risk; insight; instructor; medical schools; mortality; multiplex assay; novel coronavirus; pandemic disease; post-COVID-19; prevent; professor; recruit; research study; risk variant; sex

PROJECT SUMMARY/ABSTRACT Candidate Steven Menez, MD, MHS, is an Instructor of Medicine in the Division of Nephrology at Johns Hopkins University School of Medicine, who will be promoted to Assistant Professor of Medicine on July 1, 2020. He seeks a K23 Mentored Patient-Oriented Research Career Development Award in order to develop and execute his proposed research project aimed at investigating the long-term kidney outcomes in hospitalized patients diagnosed with the novel Coronavirus Disease 2019 (COVID-19) surviving to discharge. This proposal additionally details a five-year plan consisting of advanced training in analytic methods and research study design, as well as mentorship by Chirag Parikh, MD, PhD, and Morgan Grams, MD, PhD. Dr. Menez’s immediate career goals include the investigation of kidney injury and inflammation phenotypes in hospitalized patients with COVID-19 surviving to discharge and the evaluation of long-term kidney outcomes and mortality in COVID-19 hospitalization survivors. His long-term goal is to become an independent physician-scientist specializing in translational AKI research, with a specific focus on preventing the progression of CKD after AKI, in particular viral-associated AKI. Throughout this award process he will enrich his education and training through additional classes at the Johns Hopkins Bloomberg School of Public Health, in addition to working closely with his team of mentors and advisors. Dr. Menez’s proposed work will help in his transition to an R01- funded independent investigator. Project Over 6 million people worldwide have been diagnosed with COVID-19.1,2 Acute kidney injury (AKI) is a frequent complication in hospitalizations for COVID-19, which has been associated with poor short-term outcomes, including in-hospital mortality.3,4 The goals of this proposal are to investigate the prevalence of elevated albuminuria and other biomarkers of kidney injury and inflammation at 3 months post-discharge in 250 patients with COVID-19 surviving hospitalization, and to associate these markers with kidney function decline and mortality at 24 months. This study will also quantify changes in kidney function over time in a larger cohort of all patients in the Johns Hopkins Health System admitted with COVID-19 (N~2000). The candidate hypothesizes that patients hospitalized with COVID-19 who develop clinical AKI and survive to discharge will have significantly greater albuminuria and higher levels of biomarkers of kidney injury and inflammation at 3 months post-discharge, and these phenotypes will associate with worse kidney outcomes and mortality up to 24 months. Further, he hypothesizes that patients with clinical AKI in the hospital will have worse kidney function decline and higher mortality at 24 months than patients without clinical AKI.

项目总结/摘要 候选 Steven Menez，医学博士，MHS，是约翰霍普金斯大学肾脏科的医学讲师 大学医学院，谁将晋升为医学助理教授2020年7月1日。他 寻求K23指导以患者为导向的研究职业发展奖，以开发和执行 他提出的研究项目旨在调查住院患者的长期肾脏结果， 被诊断患有2019新型冠状病毒病（COVID-19），并存活至出院。这项建议 此外，还详细介绍了一个五年计划，包括分析方法和研究学习的高级培训 设计，以及由Chirag Parikh，MD，PhD和Morgan Grams，MD，PhD指导。梅内兹医生 近期职业目标包括研究住院患者的肾损伤和炎症表型， 存活出院的COVID-19患者以及长期肾脏结局和死亡率的评估 在COVID-19住院幸存者中。他的长期目标是成为一名独立的物理学家兼科学家 专门从事阿基研究，特别关注预防阿基后CKD的进展， 特别是病毒相关阿基。在整个获奖过程中，他将丰富他的教育和培训 除了工作，我还在约翰霍普金斯布隆伯格公共卫生学院上了额外的课程， 与他的导师和顾问团队密切合作。梅内兹博士提出的工作将有助于他过渡到R 01- 资助的独立调查员 项目 全球已有超过600万人被诊断患有COVID-19。1，2急性肾损伤（阿基）是常见的 COVID-19住院并发症，这与短期结果不佳有关， 包括住院死亡率。3，4本提案的目的是调查 250例患者出院后3个月的白蛋白尿和其他肾损伤和炎症生物标志物 COVID-19存活住院，并将这些标志物与肾功能下降和 24个月时的死亡率。这项研究还将在一个更大的队列中量化肾功能随时间的变化， 约翰霍普金斯卫生系统收治的所有COVID-19患者（N~2000）。候选 假设因COVID-19住院并发生临床阿基并存活至出院的患者将 在3岁时，蛋白尿明显增多，肾损伤和炎症的生物标志物水平也更高 这些表型将与更差的肾脏结局和死亡率相关， 24个月此外，他假设在医院中患有临床阿基的患者的肾脏会更差， 与无临床阿基的患者相比，24个月时的功能下降和死亡率更高。