1Florida Alzheimer's Disease Research Center Biomarker Core

1佛罗里达阿尔茨海默病研究中心生物标志物核心

• 批准号: 10190777
• 负责人: David E Vaillancourt
• 金额: $ 27.62万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10190777
• 关键词: African American; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Amyloid; Amyloid beta-Protein; Amyloid deposition; Autopsy; Back; Biological; Biological Assay; Biological Markers; Characteristics; Classification Scheme; Clinical; Clinical Data; Cognitive aging; Communication; Data; Data Set; Databases; Dementia; Diffusion; Disease Progression; Education; Elderly; Florida; Funding; Future; Goals; Gold; Grant; Hippocampus (Brain); Hispanic Americans; Image; Individual; Infrastructure; Light; Machine Learning; Magnetic Resonance Imaging; Measures; Memory Disorders; Mission; Modality; Multimodal Imaging; Nerve Degeneration; Neurites; Online Systems; Participant; Pathology; Pathway interactions; Plasma; Positron-Emission Tomography; Process; Protocols documentation; Proxy; Publishing; Research; Research Personnel; Research Training; Site; Structure; Time; Universities; Water; Work; base; cognitive neuroscience; cohort; computational platform; computerized data processing; data management; data sharing; deep learning; demographics; density; healthy aging; image processing; imaging modality; in vivo; innovation; machine learning algorithm; multimodal data; multimodality; neurofilament; neuroimaging; novel; software development; specific biomarkers; support vector machine; tau Proteins; tractography; web services; white matter; β-amyloid burden

SUMMARY: Biomarker Core Alzheimer’s disease (AD) classically develops in the elderly. The classical way to confirm an AD diagnosis is the presence of amyloid deposition and tau pathology at post-mortem; however in-vivo biomarkers can serve as proxies of these characteristics and are invaluable in separating healthy aging from AD as well as placing individuals along the AD continuum. The Biomarker Core works closely with the three Clinical Core sites across Miami and Gainesville, as well as the Data Core to provide timely access to raw, pre-processed, and post- processed data. The Aims of this Biomarker Core include: 1) Web-based Neuroimaging Portal for Accessing, Visualizing, and Sharing Multimodal Imaging Data. 2) Integrating New Imaging and Biofluid Modalities into the Neuroimaging Portal. 3) Multimodal, Multiclass, and Machine Learning Algorithms of Imaging and Biofluid Markers. 4) Provide Support for Ongoing and Future R01, U01, REC, K01, K99, T32, and F32 grants across the network of Florida and non-Florida Projects. There is a rich and expansive group of grants that will be able to leverage the biomarker datasets acquired within the Clinical Core, including those funded as part of the Research and Education Core (REC). This core will provide the needed communication, data sharing, analysis support, and neuroimaging training for research in these projects to proceed. We believe that this study, which would be one of the largest of its kind, will combine data acquired at the Wien Center for Alzheimer’s Disease and Memory Disorders, UM Center for Cognitive Neuroscience and Aging, and University of Florida. Access to this new multimodal dataset in AD and other dementias will provide added statistical meaningfulness in studying dementia and inclusion of a large number of Hispanics and African Americans, which is much needed given the current demographics of the popular ADNI database.

摘要：生物标志物核心 阿尔茨海默氏病（AD）经典地在古老的角度发展。确认AD诊断的经典方法是 验尸后存在淀粉样蛋白沉积和tau病理学；但是，体内生物标志物可以作为 这些特征的代表，在将健康的衰老与AD分开以及放置方面是无价的 沿广告连续体的个人。生物标志物核心与三个临床核心部位紧密合作 迈阿密和盖恩斯维尔以及数据核心，可及时访问原始，预处理和后 处理的数据。该生物标志物核心的目的包括：1）基于Web的神经成像门户用于访问， 可视化和共享多模式成像数据。 2）将新的成像和生物流体方式整合到 神经影像门户。 3）成像和生物流体的多模式，多类和机器学习算法 标记。 4）为正在进行和未来的R01，U01，REC，K01，K99，T32和F32的支持提供支持 佛罗里达州和非氯化氯化氯化绿色项目的网络。有一群丰富而广泛的赠款能够 利用临床核心内获得的生物标志物数据集，包括作为研究的一部分资助的生物标志物 和教育核心（REC）。该核心将提供所需的通信，数据共享，分析支持， 以及在这些项目中进行研究的神经影像学培训。我们认为这项研究将是 同类中最大的是，将在阿尔茨海默氏病和记忆中心中获得的数据结合 疾病，UM认知神经科学与衰老中心以及佛罗里达大学。访问这个新的 AD和其他痴呆症中的多模式数据集将在研究痴呆症时提供额外的统计意义 以及包括大量西班牙裔和非洲裔美国人，鉴于当前 流行的ADNI数据库的人口统计。