Workshop on Techniques in Modeling Human Cancer in Mice

项目总结/摘要 本年度“小鼠人类癌症建模技术研讨会”的总体目标是 申请是提供一个密集的尖端培训讲习班在实验室模拟人类癌症 一小群经过挑选的早期职业科学家/实习生。完成课程的参与者将获得 如何表征和分析人类癌症小鼠模型的工作知识。 该课程将包括上午的教学讲座，介绍特定的器官部位和 与这些器官部位相关的癌症的特征，然后是密集的动手实验室课程 借此学生将获得人类癌症小鼠模型的操作和分析经验。作为 作为基因工程和突变小鼠模型的全球资源，JAX具有独特的定位，可以提供 这是世界上其他任何地方都没有的实践培训经验。会议还将包括成像 技术、肿瘤植入的手术方法和病理学。此外，参与者还拥有 有机会展示他们的工作，并从课程教师和参与者获得建设性的反馈。 JAX致力于培养多样化的生物医学科学家。在NCI和 霍华德休斯医学研究所，我们将积极招募和培训代表性不足的少数民族（URM）的参与者 通过广泛的伙伴关系，周到的规划和奖学金资源的使用。此外，我们将 积极寻求并邀请URM担任研讨会教员。 这个为期7天的强化沉浸式课程将提供给20名因其出色的研究而被选中的参与者 潜力他们将与来自JAX的一组著名的小鼠遗传学家和癌症生物学家进行互动 和其他著名机构。班级的规模将被故意保持在较小的规模，以实现 学生与教师互动的理想水平，并允许广泛的实验室培训和实践。过程 将每年在公海举行，我们的住宅会议设施和我们的设备齐全的应用 基因组训练实验室杰克逊实验室是一个国家癌症研究所指定的基础研究癌症中心， 有着举办高级课程和科学会议的悠久历史。

PROJECT SUMMARY/ABSTRACT The overall goal for the annual “Workshop on Techniques in Modeling Human Cancer in Mice” proposed in this application is to deliver an intensive cutting-edge training workshop on modeling human cancer in the laboratory mouse to a small group of select early career scientists/trainees. Participants completing the course will acquire a working knowledge of how to characterize and analyze mouse models of human cancer. The course will consist of didactic lectures in the morning to introduce particular organ sites and the characteristics of cancers associated with those organ sites, followed by intensive hands-on laboratory sessions whereby students will gain experience in the manipulation and analysis of mouse models of human cancer. As a global resource for genetically engineered and mutant mouse models, JAX is uniquely positioned to provide a hands-on training experience that is not available anywhere else in the world. Sessions will also include imaging techniques, surgical approaches to the implantation of tumors and pathology. Additionally, participants have the opportunity to present their work and receive constructive feedback from course faculty and participants. JAX is deeply committed to training a diverse group of biomedical scientists. With support from NCI and the Howard Hughes Medical Institute, we will actively recruit and train under-represented minority (URM) participants through extensive partnerships, thoughtful planning and use of scholarship resources. Additionally, we will actively seek and invite URMs to serve as workshop faculty. This intensive 7-day immersive course will be offered to 20 participants selected for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from JAX and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction and to permit extensive laboratory training and practice. The course will be held annually at Highseas, our residential conference facility and our generously equipped applied genomic training laboratory. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings.