Workshop on Techniques in Modeling Human Cancer in Mice

项目摘要/摘要 一年一度的“小鼠人类肿瘤模型制作技术研讨会”的总体目标是 应用是在实验室提供关于建立人类癌症模型的强化尖端培训讲习班 鼠标指向一小群精选的早期职业科学家/实习生。完成课程的学员将获得 关于如何描述和分析人类癌症的小鼠模型的实用知识。 这门课程将包括上午的说教讲座，介绍特定的器官部位和 与这些器官部位相关的癌症的特征，随后是密集的动手实验室会议 学生将在人类癌症的老鼠模型的操作和分析方面获得经验。AS 作为基因工程和突变小鼠模型的全球资源，JAX具有独特的定位，可以提供 实践培训体验，这在世界其他任何地方都是不存在的。会议还将包括成像 肿瘤植入的技术、外科方法和病理学。此外，参与者还拥有 有机会展示他们的工作，并从课程教职员工和参与者那里获得建设性的反馈。 贾克斯致力于培养一批多元化的生物医学科学家。在NCI和 霍华德·休斯医学院，我们将积极招募和培训代表不足的少数族裔(URM)参与者 通过广泛的合作伙伴关系，深思熟虑地规划和使用奖学金资源。此外，我们还将 积极寻找并邀请城市管理人员担任研修班教师。 这一为期7天的强化沉浸式课程将提供给20名因杰出研究而被选中的参与者。 潜力。他们将与来自JAX的一群著名的小鼠遗传学家和癌症生物学家进行互动 和其他知名机构。班级的人数将被故意保持在较小的水平，以实现 良好的师生互动水平，并允许广泛的实验室培训和实践。这门课 将每年在我们的住宅会议设施和我们慷慨的设备适用的公海举行 基因组训练实验室。杰克逊实验室是美国国家癌症研究所指定的基础研究癌症中心， 有举办高级课程和科学会议的悠久历史。

PROJECT SUMMARY/ABSTRACT The overall goal for the annual “Workshop on Techniques in Modeling Human Cancer in Mice” proposed in this application is to deliver an intensive cutting-edge training workshop on modeling human cancer in the laboratory mouse to a small group of select early career scientists/trainees. Participants completing the course will acquire a working knowledge of how to characterize and analyze mouse models of human cancer. The course will consist of didactic lectures in the morning to introduce particular organ sites and the characteristics of cancers associated with those organ sites, followed by intensive hands-on laboratory sessions whereby students will gain experience in the manipulation and analysis of mouse models of human cancer. As a global resource for genetically engineered and mutant mouse models, JAX is uniquely positioned to provide a hands-on training experience that is not available anywhere else in the world. Sessions will also include imaging techniques, surgical approaches to the implantation of tumors and pathology. Additionally, participants have the opportunity to present their work and receive constructive feedback from course faculty and participants. JAX is deeply committed to training a diverse group of biomedical scientists. With support from NCI and the Howard Hughes Medical Institute, we will actively recruit and train under-represented minority (URM) participants through extensive partnerships, thoughtful planning and use of scholarship resources. Additionally, we will actively seek and invite URMs to serve as workshop faculty. This intensive 7-day immersive course will be offered to 20 participants selected for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from JAX and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction and to permit extensive laboratory training and practice. The course will be held annually at Highseas, our residential conference facility and our generously equipped applied genomic training laboratory. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings.