Clonal hematopoiesis and severity of COVID-19 disease

克隆造血和 COVID-19 疾病的严重程度

基本信息

  • 批准号:
    10196497
  • 负责人:
  • 金额:
    $ 33.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-01 至 2023-02-28
  • 项目状态:
    已结题

项目摘要

SUMMARY COVID-19 disease has a diverse range of outcomes, and this individual-to-individual variability is poorly understood. Clonal hematopoiesis is a prevalent, age-associated condition that arises from the accumulation of various somatic mutations in hematopoietic cells and can lead to their clonal amplification. These mutant clones corrupt immune cell function and contribute to mortality and increased cardiovascular disease risk through cytokine dysregulation. The proposed research will investigate the hypothesis that clonal hematopoiesis is a hematologic host factor that predisposes persons to develop severe COVID-19 disease. Through a collaborative effort between Kenneth Walsh Ph.D. (UVA) and Christopher deFilippi M.D. (Inova) the proposed research will explore the possibility that clonal hematopoiesis-mediated alterations to the immune system are associated with clinical laboratory measures of a marked inflammatory response, biochemical evidence of cardiac injury and poor clinical outcomes in patients with COVID-19 infection. Patients will be consented and enrolled at the Inova hospital system in northern Virginia that delivers service to more than 2 million people per year in the Washington, D.C metro area with a large volume of hospitalized COVID-19 positive patients. Upon enrollment, biospecimens will be collected and banked. Clinical data will be extracted from the electronic medical record and stored in research form in Research Electronic Data Capture software. DNA will be sent to Dr. Walsh’s laboratory at UVA for analysis of clonal hematopoiesis. DNA from the Inova group will be processed at UVA to assess clonal hematopoiesis via targeted, error-corrected DNA sequencing. This analysis employs an enrichment panel to capture driver genes of interest and the construction of libraries with DNA barcodes. Following deep next generation DNA sequencing, a bioinformatic platform is employed to distinguish true variant calls from noise at a particular exonic location. These data on clonal hematopoiesis will then be shared with the team at Inova to test whether there are associations between somatic mutations, clinical outcome, and markers of inflammation and cardiac injury.
总结

项目成果

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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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KENNETH WALSH其他文献

KENNETH WALSH的其他文献

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{{ truncateString('KENNETH WALSH', 18)}}的其他基金

Clonal hematopoiesis and severity of COVID-19 disease
克隆造血和 COVID-19 疾病的严重程度
  • 批准号:
    10413986
  • 财政年份:
    2021
  • 资助金额:
    $ 33.66万
  • 项目类别:
Mosaic loss of Y chromosome in blood and heart failure
血液中 Y 染色体马赛克丢失与心力衰竭
  • 批准号:
    10277645
  • 财政年份:
    2021
  • 资助金额:
    $ 33.66万
  • 项目类别:
Mosaic loss of Y chromosome in blood and heart failure
血液中 Y 染色体马赛克丢失与心力衰竭
  • 批准号:
    10714372
  • 财政年份:
    2021
  • 资助金额:
    $ 33.66万
  • 项目类别:
Mosaic loss of Y chromosome in blood and heart failure
血液中 Y 染色体马赛克丢失与心力衰竭
  • 批准号:
    10646348
  • 财政年份:
    2021
  • 资助金额:
    $ 33.66万
  • 项目类别:
Role of therapy-related clonal hematopoiesis in anthracycline-induced cardiotoxicity
治疗相关克隆造血在蒽环类药物引起的心脏毒性中的作用
  • 批准号:
    10172973
  • 财政年份:
    2020
  • 资助金额:
    $ 33.66万
  • 项目类别:
Role of therapy-related clonal hematopoiesis in anthracycline-induced cardiotoxicity
治疗相关克隆造血在蒽环类药物引起的心脏毒性中的作用
  • 批准号:
    10394732
  • 财政年份:
    2020
  • 资助金额:
    $ 33.66万
  • 项目类别:
Role of therapy-related clonal hematopoiesis in anthracycline-induced cardiotoxicity
治疗相关克隆造血在蒽环类药物引起的心脏毒性中的作用
  • 批准号:
    10614493
  • 财政年份:
    2020
  • 资助金额:
    $ 33.66万
  • 项目类别:
Hematopoietic stem cell mutations and ischemic cardio-metabolic disease
造血干细胞突变与缺血性心脏代谢疾病
  • 批准号:
    9900053
  • 财政年份:
    2019
  • 资助金额:
    $ 33.66万
  • 项目类别:
Hematopoietic stem cell mutations and ischemic cardio-metabolic disease
造血干细胞突变与缺血性心脏代谢疾病
  • 批准号:
    10378063
  • 财政年份:
    2019
  • 资助金额:
    $ 33.66万
  • 项目类别:
Clonal hematopoiesis and accelerated metabolic dysfunction in obesity
肥胖症中的克隆造血和加速代谢功能障碍
  • 批准号:
    10390471
  • 财政年份:
    2019
  • 资助金额:
    $ 33.66万
  • 项目类别:

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