课题基金 / 基金详情

Innate immune cell contribution in wood smoke induced effects to pulmonary function

Innate immune cell contribution in wood smoke induced effects to pulmonary function
先天免疫细胞在木烟中的作用对肺功能产生影响
批准号:
10195519
负责人:
CHRISTOPHER Todd MIGLIACCIO
金额:
$22.15万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-03-17 至 2023-02-28

项目摘要

项目成果

CHRISTOPHER Todd MIGLIACCIO的其他基金

相似基金

相关文献

中文摘要
翻译
天然免疫细胞在木材烟雾对肺功能影响中的作用 野火是一个日益严重的全球问题,也是公众健康的一个重大问题。每年,野火都在继续 世界各地数以万计的大火和数百万英亩的大火成为头条新闻。由于…的影响 随着气候的变化,这些野火变得更加激烈,燃烧的时间也越来越长。尽管野火威胁到 直接影响生命,而野火烟雾影响我们所有人--特别是在野火的强度和持续时间不断升级的情况下 全球范围内。令人兴奋的新的初步数据显示,来自一个社区的个人被危险物质淹没 持续49天的野火烟雾水平(日平均值:PM2.5微克/立方米)显示出以下显著下降 野火事件后至少两年的肺功能,在年龄较大的(65岁)观察到的影响更大 队列中的一小部分。此外,我们还显示了肺部炎症和呼吸道高反应性, 在我们的急性木材烟雾暴露的小鼠模型中,细胞因子介体的促进作用。这样做的目的是 建议确定野火烟雾如何影响先天免疫、巨噬细胞亚群和 先天淋巴样细胞,产生警报和炎症介质,导致组织重塑和 肺功能下降。我们提出的中心假设是ILC2活动是由IL-33启动的 和巨噬细胞对木材烟雾暴露的反应,导致产生和释放 引发病理变化的炎性介质。为了有效地检验这一假设,以下是具体的 目标1:接触WS将导致时间、剂量、年龄和性别相关的不良反应 对肺部的影响。目标2:暴露在高水平的野火烟雾中将导致先天免疫力的改变 促进肺部组织重塑的成分。拟议的研究将利用最新情况- 蒙大拿大学ART吸入和肺生理学核心设施开发小鼠模型 社区曝光率。 影响 总之,拟议的尖端小鼠研究补充了正在进行的独特的纵向人类 研究将对野火烟雾引起的健康影响和巨噬细胞产生持续而强大的影响 免疫生物学。该项目的成功完成将为一部小说提供一个重要的缺失环节 环境对呼吸健康产生不利影响的机制,也提供了与其他 环境污染物(如香烟烟雾、柴油废气、颗粒物)可能是 肺功能减退。最后,通过了解巨噬细胞亚群如何影响炎症反应 在ILC2s中,可以更精确和更有效地开发治疗方法,从而显著 推进针对这一日益严重的公共卫生问题的治疗选择。
英文摘要
Innate immune cell contribution in wood smoke induced effects to pulmonary function Wildfires are a growing global issue, and a significant concern for public health. Each year, wildfires continue to make headlines as tens of thousands of fires and millions of acres burn around the world. Due to the effects of climate change, these wildfires have become more intense and longer burning. Although wildfires threaten lives directly, and wildfire smoke affects us all—particularly as the intensity and duration of wildfires escalates globally. exciting new preliminary data shows that individuals from a community inundated with hazardous levels of wildfire smoke (daily average: 220.9 µg/m3 of PM2.5) for 49 days exhibited a significant decrease in lung function at least two years after the wildfire event, with a greater effect observed in the older (>65 years) fraction of the cohort. Moreover, we demonstrate pulmonary inflammation and airway hyperreactivity, facilitated by cytokine mediators in our mouse model of acute wood smoke exposure. The objective of this proposal is to determine how wildfire smoke affects components of innate immunity, macrophage subsets and innate lymphoid cells, into generating alarmins and inflammatory mediators that result in tissue remodeling and decreased lung function. We propose the central hypothesis that ILC2 activities are initiated by IL-33 and macrophages in response to wood smoke exposure, resulting in the production and release of inflammatory mediators which trigger pathology. To effectively test this hypothesis, the following specific aims will be addressed: Aim 1: Exposure to WS will result in time-, dose-, age-, and sex-dependent adverse pulmonary effects. Aim 2: Exposure to high levels of wildfire smoke will result in alterations to innate immune components that will promote tissue remodeling in the lungs. The proposed studies will utilize the state-of-the- art Inhalation and Pulmonary Physiology Core facility at the University of Montana to develop a mouse model of the community exposures. Impact Together, the proposed cutting-edge murine studies complementing the ongoing unique longitudinal human studies will have a sustained and powerful impact on wildfire smoke-induced health effects and macrophage immunobiology. The successful completion of the project will provide a significant missing link into a novel mechanism by which the environment adversely affects respiratory health, and also provide a link to how other environmental pollutants (e.g. cigarette smoke, diesel exhaust, particulate matter) may serve as risk factors for diminished lung function. Lastly by understanding how macrophage subsets influence inflammatory responses in ILC2s, therapeutic approaches can be developed with greater precision and efficacy, thereby significantly advancing treatment options for this growing public health concern.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Innate immune cell contribution in wood smoke induced effects to pulmonary function
  • 批准号:
    10373084
  • 项目类别:
  • 资助金额:
    $18.5万
  • 财政年份:
    2021
  • 负责人:
    CHRISTOPHER Todd MIGLIACCIO
  • 依托单位:
THE ROLE OF PULMONARY SUBPOPULATIONS AND TH2 IMMUNITY IN BALB/C SILICOSIS MODEL
  • 批准号:
    8360469
  • 项目类别:
  • 资助金额:
    $2.05万
  • 财政年份:
    2011
  • 负责人:
    CHRISTOPHER Todd MIGLIACCIO
  • 依托单位:
REGULATION OF MACROPHAGE FUNCTION BY COMPONENTS OF WOODSMOKE
  • 批准号:
    8360466
  • 项目类别:
  • 资助金额:
    $16.81万
  • 财政年份:
    2011
  • 负责人:
    CHRISTOPHER Todd MIGLIACCIO
  • 依托单位:
REGULATION OF MACROPHAGE FUNCTION BY COMPONENTS OF WOODSMOKE
  • 批准号:
    8167597
  • 项目类别:
  • 资助金额:
    $15.23万
  • 财政年份:
    2010
  • 负责人:
    CHRISTOPHER Todd MIGLIACCIO
  • 依托单位:
海外基金