Pilot Administrative Core - Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions

试点行政核心是“症状科学研究中心”的一个组成部分， 代谢组学和多种慢性病“将产生和支持先导研究人员和研究 解决多种慢性病(MCC)的症状。尽管MCC在成年人中有所增加，但几乎没有 了解复杂和协同作用的代谢物和潜在症状的代谢途径，因此 症状管理干预措施不发达。整体中心建议推进 了解症状，解决知识中的差距，从而更准确地减轻症状 干预措施。试点行政核心将对具体和令人痛苦的症状进行研究 患有慢性疾病和高血压(HTN)的黑人成年人的疲劳、抑郁和焦虑 慢性疾病是造成MCC和健康差距的重要原因。试点研究将审查 与症状和症状群相关的个人、生物和行为因素，并检查 与这些症状相关的代谢物和代谢途径。由于该中心的科学框架是 经过测试和改进的代谢途径可能会被发现，这可能有助于未来的干预工作。这个 试点行政核心将作为跨学科研究的孵化器，基于该中心的 由高分辨代谢组学衍生的症状、簇和代谢物的科学框架 黑人成年人患有MCC，并将扩大试点研究项目的数量和质量。总体目标 目的是：1.通过支持两项初步的先导研究，培养专注于该中心科学领域的研究人员 在1-2年内，并支持跨学科调查小组为以下项目开发另外三项试点研究 3-5年；2.为项目监督、试点调查员指导和培训提供支持性基础设施， 以及获得侧重于症状机制的资源(代谢组学和微生物组) 通过应用智力、方法、伦理和跨学科资源来开发和 实施科学严谨的试点研究；以及3.为试点的成功传播提供指导 研究，并对试点研究的结果、效果大小和资源进行严格评估，以发展未来 严谨的研究和R01级的拨款申请。办法包括招募未来的试点申请， 严格的科学审查，监测试点进展，对试点调查人员进行跨学科指导，以及 统一方法，包括共同数据要素和创新数据分析。建议的两项 试点项目将针对患有HTN以及肥胖或艾滋病毒感染的人群。通过对...的发现 对于该中心，我们展望了该框架的未来扩展，以支持对症状和 MCC中的症状群包括HTN和其他黑人成年人的慢性疾病。这些研究将 提供基本知识以最终提高MCC的生活质量，并将中心调查人员定位为 以创新和精确的方法进行未来的调查。

The Pilot Administrative Core, a component of the “Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions,” will generate and support pilot investigators and studies addressing symptoms in multiple chronic conditions (MCC). Although MCCs are increasing in adults, little is known about the complex and synergizing metabolites and metabolic pathways underlying symptoms, thus symptom management interventions are under-developed. The overall Center proposes to advance the understanding of symptoms to address the gaps in knowledge that will lead to more precise symptom-reducing interventions. The Pilot Administrative Core will generate research on the specific and distressing symptoms of fatigue, depression and anxiety in Black adults living with a chronic condition and hypertension (HTN), a chronic condition that significantly contributes to MCC and health disparities. Pilot studies will examine individual, biological, and behavioral factors related to the symptoms and symptom clusters, and examine metabolites and metabolic pathways associated with these symptoms. As the Center's scientific framework is tested and refined, metabolic pathways may be uncovered that may contribute to future intervention work. The Pilot Administrative Core will function as an incubator for interdisciplinary research based on the Center's scientific framework of symptoms and clusters and metabolites derived from high resolution metabolomics in Black adults with MCC and will expand the number and quality of pilot research projects. The overall aims are to: 1. Develop researchers focused on the Center's area of science by supporting two initial pilot studies in years 1-2, and supporting interdisciplinary investigator teams to develop three additional pilot studies for years 3-5; 2. Provide a supportive infrastructure for project oversight, pilot investigator mentoring and training, and access to resources focused on the mechanisms of symptoms (metabolomics and the microbiome) through application of intellectual, methodological, ethical, and interdisciplinary resources to develop and implement scientifically rigorous pilot studies; and 3. Provide mentoring for successful dissemination of pilot studies, with critical assessment of pilot study outcomes, effect sizes and resources in order to develop future rigorous studies and R01-level grant applications. Approaches include recruitment of future pilot applications, rigorous scientific reviews, monitoring of pilot progress, interdisciplinary mentoring of pilot investigators, and harmonization of methods including common data elements and innovative data analysis. The proposed two pilot projects will address populations with HTN and either obesity or HIV infections. Through the discoveries of the Center, we envision future extension of the framework to support sustained inquiry on symptom and symptom clusters within MCC including HTN and other chronic conditions in Black adults. These studies will contribute essential knowledge to ultimately improve quality of life in MCC and position Center investigators to conduct future inquiry with innovative and precision approaches.