Center for Integrative Neuroscience

项目总结/摘要 整体 该建议是继续发展生物医学研究卓越中心（COBRE）， 内华达州里诺大学（UNR）的综合神经科学。在全国范围内，神经科学的进步 正在许多方面进行，并解决基础和临床科学中的基本问题。的 COBRE在UNR的成立是为了协同和提高UNR神经科学研究的能力， 在内华达州，已经建立了一个专门的研究小组， 认知或细胞神经科学或生物工程方面的专业知识; 2）提供现代基础设施 需要在该领域开展有影响力的研究项目。第一阶段支持了七个项目和五个试点项目， 涵盖基础和临床研究的项目。指导的项目领导人取得了很高的成就 在同行评审的出版物和NIH和NSF的资金生产力。第一阶段还开展了研究 具有高影响力和使用的核心，包括建立该地区第一个功能磁共振成像设施。的资源 通过核心提供的已经远远超出了最初的目标，并已安装的方式， 成本效益高，可持续性强。第二阶段将进一步扩大和巩固这些成功， 最初的5个项目团队将继续建立UNR在细胞和认知神经科学方面的实力 同时也瞄准了计算神经科学的战略增长。项目负责人将由一名 强大的成功研究人员团队，他们将带来来自许多学科的观点和专业知识， 选择一个框架来促进真实的跨学科合作。神经影像学研究核心， 分子成像将扩大到提供一系列关键工具和培训， 并为COBRE项目和更广泛的神经科学界开辟新的研究机会。一个新 还将开发一个核心，以支持虚拟和增强现实的应用， 神经科学，一个我们再次确定具有高潜在影响和需求的领域。最后，COBRE将 继续推动UNR其他神经科学计划的快速增长，成为一个 新的神经科学研究所将在第二阶段开始时在大学的支持下建立。这 将使该中心的研究目标与最近启动的研究生项目联系起来，并发挥作用 在综合神经科学，并开始过渡到一个永久性的和自我维持的研究中心。

PROJECT SUMMARY/ABSTRACT Overall This proposal is continue the development of a Center of Biomedical Research Excellence (COBRE) in Integrative Neuroscience at the University of Nevada, Reno (UNR). Nationally, advances in the neurosciences are proceeding on many fronts and addressing fundamental questions in both basic and clinical science. The COBRE at UNR was established to synergize and elevate the capacity for neuroscience research at UNR and the state of Nevada, by 1) cross-fertilizing research units that had already developed teams of focused expertise in cognitive or cellular neuroscience or bioengineering; and 2) providing the modern infrastructure required to mount impactful research programs in the field. Phase I has supported seven projects and five pilot projects spanning both basic and clinical research. Mentored project leaders have achieved very high productivity in both peer-reviewed publications and NIH and NSF funding. Phase I also developed research cores with high impact and use, including establishing the first fMRI facility in the region. The resources provided through the cores have expanded far beyond the original aims, and have been mounted in ways that are highly cost-effective and sustainable. Phase II will further expand and solidify these successes, supporting an initial team of 5 projects that will continue to build UNR’s strength in cellular and cognitive neuroscience while also targeting strategic growth in computational neuroscience. The project leaders will be mentored by a strong team of successful researchers who will bring perspectives and expertise drawn from many disciplines, with a framework chosen to foster real interdisciplinary collaborations. Research cores for Neuroimaging and Molecular Imaging will be expanded to provide an array of critical tools and training that will both strengthen and open new research opportunities for COBRE projects and the broader neuroscience community. A new core will also be developed to support applications of virtual and augmented reality for sensory and cognitive neuroscience, an area where we have again identified high potential impact and need. Finally, the COBRE will continue to drive the rapid growth of other neuroscience initiatives at UNR, by becoming the research arm of a new Institute of Neuroscience that will be established with university support at the beginning of Phase II. This will allow the research aims of the center to connect with and leverage the recently initiated Graduate Program in Integrative Neuroscience, and begin the transition to a permanent and self-sustaining research center.