Center for Integrative Neuroscience

综合神经科学中心

• 批准号: 10418518
• 负责人: MICHAEL A WEBSTER
• 金额: $ 106.77万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10418518
• 关键词: Address; Area; Award; Basic Science; Behavior; Biomedical Engineering; Brain; Centers of Research Excellence; Clinical Research; Clinical Sciences; Cognition; Cognitive; Collaborations; Communities; Computer Analysis; Computer Models; Core Facility; Data; Data Analytics; Development; Discipline; Disease; Extramural Activities; Faculty; Financial Support; Fostering; Functional Magnetic Resonance Imaging; Funding; Funding Agency; Goals; Growth; Healthcare; Impairment; Infrastructure; Institutes; Institution; Knowledge; Machine Learning; Mentors; Mission; Modernization; Molecular Computations; Neurologic; Neurosciences; Neurosciences Research; Nevada; Output; Peer Review; Phase; Pilot Projects; Positioning Attribute; Productivity; Publications; Research; Research Infrastructure; Research Personnel; Research Priority; Research Support; Research Training; Resources; Scientific Advances and Accomplishments; Secure; Services; Time; Training Programs; United States National Institutes of Health; Universities; Virtual and Augmented reality; arm; base; cellular imaging; computational neuroscience; cost; cost effective; deep learning; design; driving force; molecular imaging; neuroimaging; programs; rapid growth; relating to nervous system; research facility; success; sustainable resource; synergism; tenure track; undergraduate student; virtual reality

Project Summary Overall This proposal is to continue the development of a Center of Biomedical Research Excellence (COBRE) in Integrative Neuroscience at the University of Nevada, Reno (UNR). Nationally, advances in the neurosciences are proceeding on many fronts and addressing fundamental questions in both basic and clinical science. The COBRE at UNR was established to synergize and elevate the capacity for neuroscience research at UNR and the state of Nevada, by 1) cross-fertilizing research units that had already developed teams of focused expertise in cognitive or cellular neuroscience or bioengineering; and 2) providing the modern infrastructure required to mount impactful research programs in the field. Phase I and II have supported 24 tenure-track junior faculty in both basic and clinical research. These mentored project leaders have achieved very high productivity in both peer-reviewed publications and NIH, NSF, and agency funding. Phases I and II also developed research cores with high impact and use, including establishing the first fMRI facility in the region. The resources provided through the cores have expanded far beyond the original aims, and have been mounted in ways that are highly cost-effective and sustainable. Phase III will further expand and solidify these successes, supporting four research cores for 1) Neuroimaging; 2) Computational Modeling and Analysis; 3) Cellular and Molecular Imaging; and 4) Virtual and Augmented Reality Interactions. The Computational Core represents an expansion of the data analytics services supported in Phase II to include facilities and technical support for AI and deep learning, and will fill an area we have identified of high potential impact and need. The cores will continue to serve a large number of investigators and their teams and the user base will be further expanded and strengthened by a Pilot Project Program providing investigator project support and a pool of funds for using core facilities. Finally, the COBRE will continue to drive the rapid growth of other neuroscience initiatives at UNR, by becoming the research arm of the Institute of Neuroscience established with university support at the beginning of Phase II. This will allow the research aims of the center to connect with and leverage the broader neuroscience research and training initiatives at the university, and to transition to a permanent and sustained research center.

项目摘要 整体 该提案将继续发展生物医学研究卓越中心（COBRE）， 内华达州里诺大学（UNR）的综合神经科学。在全国范围内，神经科学的进展 正在许多方面进行，并解决基础和临床科学中的基本问题。的 COBRE在UNR的成立是为了协同和提高UNR神经科学研究的能力， 在内华达州，已经建立了一个专门的研究小组， 认知或细胞神经科学或生物工程方面的专业知识; 2）提供现代基础设施 需要在该领域开展有影响力的研究项目。第一阶段和第二阶段支持了24个终身教职轨道 初级教员在基础和临床研究。这些受指导的项目负责人取得了很高的成就， 在同行评审的出版物和NIH，NSF和机构资金的生产力。第一和第二阶段还 开发了具有高影响力和使用的研究核心，包括建立该地区第一个功能磁共振成像设施。 通过这些核心提供的资源已经远远超出了最初的目标， 以高成本效益和可持续的方式安装。第三阶段将进一步扩大和巩固这些 成功，支持四个研究核心：1）神经成像; 2）计算建模和分析; 3） 细胞和分子成像;以及4）虚拟和增强现实交互。计算核心 代表第二阶段支持的数据分析服务的扩展，包括设施和技术 支持人工智能和深度学习，并将填补我们已经确定的高潜在影响和需求的领域。的 核心系统将继续为大量调查人员及其团队服务，用户群将进一步扩大， 通过一个试点项目方案予以扩大和加强，该方案提供调查员项目支助和 使用核心设施的资金。最后，COBRE将继续推动其他神经科学的快速发展 在UNR的倡议，成为神经科学研究所的研究部门建立与大学 在第二阶段开始时提供支持。这将使该中心的研究目标能够与 利用大学更广泛的神经科学研究和培训计划，并过渡到 永久和持续的研究中心。