Biostatistics Core

生物统计学核心

• 批准号: 10197007
• 负责人: Ravi Varadhan
• 金额: $ 16.94万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-21 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197007
• 关键词: Address; Animals; Bioinformatics; Biology; Biometry; Biostatistics Core; Bone Marrow Transplantation; Cancer Biology; Clinic; Clinical; Clinical Research; Collaborations; Collection; Consultations; Custom; Data Analyses; Data Storage and Retrieval; Detection; Development; Ensure; Equipment; Experimental Designs; Faculty; Funding; Genomics; Goals; Hematologic Neoplasms; Human; Individual; Informatics; Information Storage; Information Technology; Laboratories; Laboratory Finding; Laboratory Study; Learning; Manuscripts; Methodology; Methods; Modeling; Monitor; Morbidity - disease rate; Morphologic artifacts; Oncology; Positioning Attribute; Program Research Project Grants; Quality Control; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Safety; Specialist; Techniques; Technology; Translating; Translations; Transplantation; Universities; Visualization; Work; Writing; bioinformatics resource; career; complex data; data acquisition; design; experimental analysis; genomic data; human disease; improved outcome; innovation; medical schools; member; mid-career faculty; mortality; preclinical study; programs; sound; stem; synergism; therapeutic target; tool

Biostatistics Core Project Summary The Biostatistics and Bioinformatics Core (“BB Core”) Resource will provide comprehensive biostatistics consultation and collaboration to all Research Projects in the proposed Johns Hopkins Bone Marrow Transplantation in Human Disease Program Project Grant. In addition, it will provide support for data storage, informatics, and computing, and assist with the identification and solution of complex data tasks arising in the course of project activities. Core members will work with project investigators across a wide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives, availability of public- access genomic information, and data storage), statistical quality control (including artifact detection and preprocessing of data from genomic technologies), data analysis (including visualization, biostatistical modeling, and assistance with manuscript writing), and development of innovative customized biostatistics and bioinformatics methodologies and tools if required by specific projects. The Biostatistics Core Resource is housed in the Division of Biostatistics and Bioinformatics, Department of Oncology at Johns Hopkins University School of Medicine. This Division comprises an active and committed group of biostatistics and bioinformatics faculty, as well as non-faculty biostatisticians and bioinformaticians, with access to state-of-the art equipment and a broad range of expertise. This Core Resource is the continuation of the long-standing resource within the ongoing BMT P01. Core members have a strong commitment to this P01, stemming from more than 30 years of collaboration with the BMT program. All proposed Projects make use of this Core Resource in every Aim. The primary objective of the BB Core is to guide and assist the project investigators in the design, conduct, and analysis of the laboratory and clinical studies proposed in this P01. This core is led by Dr. Ravi Varadhan, Associate Professor, Oncology Biostatistics and Bioinformatics. The Core focuses its efforts on assisting both the clinical and laboratory investigators in translating their pre-clinical studies into clinical studies by providing state-of-the-art experimental designs and analyses through statistical consultation and collaboration with respect to methodology, feasibility, safety monitoring, analysis, and reporting of clinical and laboratory studies. For more than 30 years, the BB core has been and continues to be an integral part of the research accomplishments of the individual projects of this P01 application.

生物统计学核心 项目摘要 生物统计和生物信息学核心(“BB核心”)资源将提供全面的生物统计 对拟议的约翰·霍普金斯骨髓中的所有研究项目进行咨询和合作 人类疾病中的移植项目资助。此外，它还将为数据存储提供支持， 信息学和计算，并协助识别和解决 项目活动的进程。核心成员将在广泛的范围内与项目调查人员合作 活动，包括数据采集(包括研究设计、目标的可行性、公众可获得性-- 获取基因组信息和数据存储)、统计质量控制(包括人工产物检测和 来自基因组技术的数据的预处理)、数据分析(包括可视化、生物统计建模、 并协助撰写手稿)，以及开发创新的定制生物统计学和 如果特定项目需要，生物信息学方法和工具。生物统计学核心资源是 约翰霍普金斯大学肿瘤学系生物统计和生物信息学系 医学院。该司由一个积极致力于生物统计和生物信息学的小组组成。 教员以及非教员生物统计学家和生物信息学家，可以使用最先进的设备 以及广泛的专业知识。此核心资源是长期资源在 正在进行的BMT P01。核心成员对这一P01有着强烈的承诺，源于30多年 与BMT计划的合作。所有拟议的项目在每个目标中都利用了这一核心资源。 BB核心的主要目标是指导和协助项目调查人员设计、实施、 以及对本P01中提出的实验室和临床研究的分析。这个核心是由拉维·瓦拉丹博士领导的， 肿瘤学、生物统计学和生物信息学副教授。核心中心的工作重点是帮助这两个 临床和实验室研究人员将他们的临床前研究转化为临床研究，通过提供 通过统计咨询和合作进行最先进的实验设计和分析 关于临床和实验室研究的方法学、可行性、安全性监测、分析和报告。 30多年来，BB核心一直是并将继续是研究的一个组成部分 本P01申请的个别项目完成情况。