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Neural Encoding and Auditory Perception in Cochlear Implant

人工耳蜗中的神经编码和听觉感知

基本信息

批准号：
10197094
负责人：
Shuman He
金额：
$ 45.94万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-01-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10197094
关键词：
Acoustic Nerve Acoustic Stimulation Acoustics Action Potentials Adult Adverse effects Affect Age Age-Years Auditory Auditory Evoked Potentials Auditory Perception Auditory area Auditory system Basic Science Behavioral Clinical Clinical Management Cochlear Implants Cognitive Cues Detection Deterioration Early identification Elderly Electric Stimulation Electrophysiology (science)Event-Related Potentials Evoked Potentials Foundations Goals Habilitation Hearing Impaired cognition Implant Individual Knowledge Lead Measures Modification Noise Outcome Outcome Measure Patients Pattern Performance Peripheral Procedures Process Property Protocols documentation Psychophysics Pulse Rates Reaction Time Recovery Research Speech Speech Perception Stimulus Testing Time Variant Voice Work clinical practice cognitive function comparison group deafness design evidence base experimental study improved individual variation insight neuroadaptation neurophysiology older patient programs rehabilitation strategy relating to nervous system response signal processing speech processing tool young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Cochlear implant (CI) users who are 65 years or older typically show poorer speech perception performance than younger adult CI users, especially in competing background noise. The underlying mechanisms remain unclear. Whereas declined cognitive function has been proposed as the major factor, deteriorations in the auditory system have also been suggested to be the primary reason. As a result, there is no robust indicator for optimizing programming settings or habilitation strategies for older implanted patients. This study is designed to better understand underlying neurophysiological mechanisms of speech perception deficits in older CI users. Older listeners are known to have temporal processing deficits, and temporal cues are particularly important for discriminating speech in CI users. Therefore, the proposed study will focus on comparing peripheral and central auditory neural encoding of, and perceptual sensitivity to, temporal envelope cues between younger and older adult CI users. Aim 1 will assess group differences in temporal responsiveness of the auditory nerve in younger (< 60 years) and older (between 65 and 85 years) adult CI users. The group comparison will be done for three temporal properties of the auditory nerve: peri-stimulus neural adaptation, adaptation recovery and the accuracy of amplitude modulation encoding. Aim 2 will assess group differences in neural representation at the auditory cortex (i.e. cortical encoding) of, and perceptual sensitivity to, temporal gaps and voice onset time, as well as their association with speech perception in younger and older adult CI users. Aim 3 will evaluate contributions of differences in AN temporal responsiveness and cortical encoding of temporal gaps and amplitude modulation to variations in perceptual envelope sensitivity in individual adult CI users. For experiments in Aims 2 and 3, psychophysical procedures and electrophysiological measures of peripherally and centrally generated evoked potentials will be combined and applied in concert in the same CI users. In addition, cognitive functions will be evaluated and used as one of the predictors for behavioral results. Results of this study have substantial significance from both a basic science and a clinical management point of view. For example, these results will provide information about the contributions of peripheral vs central auditory functions, as well as auditory vs cognitive factors to perceptual sensitivity to temporal gaps and amplitude modulations, which is crucial for understanding underlying mechanisms of these auditory processes. These results will also provide information about whether the accuracy of neural encoding and processing of electrical hearing declines in older CI users, as well as at which level of the auditory system this decline, if any, exists. This information could potentially lead to developing objective tools for early identification of older CI patients who may need additional rehabilitation strategies. Given the importance of temporal processing for speech perception and the rapidly increasing number of older CI patients, experiments proposed in this application are of high scientific and translational significance.

项目概要/摘要 65 岁或以上的人工耳蜗 (CI) 用户通常表现出较差的言语感知能力性能优于年轻的成年 CI 用户，尤其是在竞争背景噪音方面。底层的机制仍不清楚。尽管认知功能下降被认为是主要因素，听觉系统的恶化也被认为是主要原因。结果，有没有可靠的指标来优化老年植入患者的编程设置或康复策略。这项研究旨在更好地理解言语感知的潜在神经生理机制老年 CI 用户的缺陷。众所周知，年长的听众有时间处理缺陷和时间线索对于 CI 用户的言语辨别尤其重要。因此，拟议的研究将集中于比较外周和中枢听觉神经编码以及颞叶包络的感知敏感性年轻和老年 CI 用户之间的线索。目标 1 将评估时间上的组间差异年轻（< 60 岁）和年长（65 至 85 岁）成人 CI 中听觉神经的反应性用户。将针对听神经的三个时间特性进行组比较：周围刺激神经适应、适应恢复和调幅编码的准确性。目标 2 将评估听觉皮层（即皮层编码）和知觉神经表征的群体差异对时间间隔和发声时间的敏感性，以及它们与语音感知的关系年轻和年长的 CI 用户。目标 3 将评估 AN 时间差异的贡献时间间隙的反应性和皮质编码以及对感知变化的幅度调制单个成年 CI 用户的包络敏感性。对于目标 2 和 3 中的实验，心理物理学程序外周和中枢产生的诱发电位的电生理测量将被结合起来并在相同的 CI 用户中协同应用。此外，认知功能将被评估并用作一项行为结果的预测因子。这项研究的结果无论从基础还是从基础上都具有重大意义科学和临床管理的观点。例如，这些结果将提供有关外周听觉功能与中枢听觉功能以及听觉因素与认知因素对知觉的贡献对时间间隙和幅度调制的敏感性，这对于理解底层至关重要这些听觉过程的机制。这些结果还将提供有关是否老年 CI 用户神经编码和电听力处理的准确性下降，以及听觉系统水平的这种下降（如果有的话）是存在的。这些信息可能会导致开发早期识别可能需要额外康复策略的老年 CI 患者的客观工具。鉴于时间处理对语音感知的重要性以及老年人数量的迅速增加对于CI患者，本申请提出的实验具有很高的科学和转化意义。

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models.

DOI：
10.1016/j.heares.2022.108643
发表时间：
2022-12
期刊：
HEARING RESEARCH
影响因子：
2.8
作者：
Skidmore, Jeffrey;Ramekers, Dyan;Bruce, Ian C.;He, Shuman
通讯作者：
He, Shuman

The Effect of Increasing Interphase Gap on N1 Latency of the Electrically Evoked Compound Action Potential and the Stimulation Level Offset in Human Cochlear Implant Users.

DOI：
10.1097/aud.0000000000000919
发表时间：
2021
期刊：
Ear and hearing
影响因子：
3.7
作者：
Skidmore J;He S
通讯作者：
He S

Prediction of the Functional Status of the Cochlear Nerve in Individual Cochlear Implant Users Using Machine Learning and Electrophysiological Measures.

DOI：
10.1097/aud.0000000000000916
发表时间：
2021
期刊：
Ear and hearing
影响因子：
3.7
作者：
Skidmore J;Xu L;Chao X;Riggs WJ;Pellittieri A;Vaughan C;Ning X;Wang R;Luo J;He S
通讯作者：
He S

A new method for removing artifacts from recordings of the electrically evoked compound action potential: Single-pulse stimulation.

一种从电诱发复合动作电位记录中去除伪影的新方法：单脉冲刺激。