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Neural Encoding and Auditory Perception in Cochlear Implant

人工耳蜗中的神经编码和听觉感知

基本信息

批准号：
10197094
负责人：
Shuman He
金额：
$ 45.94万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-01-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10197094
关键词：
Acoustic Nerve Acoustic Stimulation Acoustics Action Potentials Adult Adverse effects Affect Age Age-Years Auditory Auditory Evoked Potentials Auditory Perception Auditory area Auditory system Basic Science Behavioral Clinical Clinical Management Cochlear Implants Cognitive Cues Detection Deterioration Early identification Elderly Electric Stimulation Electrophysiology (science)Event-Related Potentials Evoked Potentials Foundations Goals Habilitation Hearing Impaired cognition Implant Individual Knowledge Lead Measures Modification Noise Outcome Outcome Measure Patients Pattern Performance Peripheral Procedures Process Property Protocols documentation Psychophysics Pulse Rates Reaction Time Recovery Research Speech Speech Perception Stimulus Testing Time Variant Voice Work clinical practice cognitive function comparison group deafness design evidence base experimental study improved individual variation insight neuroadaptation neurophysiology older patient programs rehabilitation strategy relating to nervous system response signal processing speech processing tool young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Cochlear implant (CI) users who are 65 years or older typically show poorer speech perception performance than younger adult CI users, especially in competing background noise. The underlying mechanisms remain unclear. Whereas declined cognitive function has been proposed as the major factor, deteriorations in the auditory system have also been suggested to be the primary reason. As a result, there is no robust indicator for optimizing programming settings or habilitation strategies for older implanted patients. This study is designed to better understand underlying neurophysiological mechanisms of speech perception deficits in older CI users. Older listeners are known to have temporal processing deficits, and temporal cues are particularly important for discriminating speech in CI users. Therefore, the proposed study will focus on comparing peripheral and central auditory neural encoding of, and perceptual sensitivity to, temporal envelope cues between younger and older adult CI users. Aim 1 will assess group differences in temporal responsiveness of the auditory nerve in younger (< 60 years) and older (between 65 and 85 years) adult CI users. The group comparison will be done for three temporal properties of the auditory nerve: peri-stimulus neural adaptation, adaptation recovery and the accuracy of amplitude modulation encoding. Aim 2 will assess group differences in neural representation at the auditory cortex (i.e. cortical encoding) of, and perceptual sensitivity to, temporal gaps and voice onset time, as well as their association with speech perception in younger and older adult CI users. Aim 3 will evaluate contributions of differences in AN temporal responsiveness and cortical encoding of temporal gaps and amplitude modulation to variations in perceptual envelope sensitivity in individual adult CI users. For experiments in Aims 2 and 3, psychophysical procedures and electrophysiological measures of peripherally and centrally generated evoked potentials will be combined and applied in concert in the same CI users. In addition, cognitive functions will be evaluated and used as one of the predictors for behavioral results. Results of this study have substantial significance from both a basic science and a clinical management point of view. For example, these results will provide information about the contributions of peripheral vs central auditory functions, as well as auditory vs cognitive factors to perceptual sensitivity to temporal gaps and amplitude modulations, which is crucial for understanding underlying mechanisms of these auditory processes. These results will also provide information about whether the accuracy of neural encoding and processing of electrical hearing declines in older CI users, as well as at which level of the auditory system this decline, if any, exists. This information could potentially lead to developing objective tools for early identification of older CI patients who may need additional rehabilitation strategies. Given the importance of temporal processing for speech perception and the rapidly increasing number of older CI patients, experiments proposed in this application are of high scientific and translational significance.

项目总结/文摘

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models.

DOI：
10.1016/j.heares.2022.108643
发表时间：
2022-12
期刊：
HEARING RESEARCH
影响因子：
2.8
作者：
Skidmore, Jeffrey;Ramekers, Dyan;Bruce, Ian C.;He, Shuman
通讯作者：
He, Shuman

The Effect of Increasing Interphase Gap on N1 Latency of the Electrically Evoked Compound Action Potential and the Stimulation Level Offset in Human Cochlear Implant Users.

DOI：
10.1097/aud.0000000000000919
发表时间：
2021
期刊：
Ear and hearing
影响因子：
3.7
作者：
Skidmore J;He S
通讯作者：
He S

Prediction of the Functional Status of the Cochlear Nerve in Individual Cochlear Implant Users Using Machine Learning and Electrophysiological Measures.

DOI：
10.1097/aud.0000000000000916
发表时间：
2021
期刊：
Ear and hearing
影响因子：
3.7
作者：
Skidmore J;Xu L;Chao X;Riggs WJ;Pellittieri A;Vaughan C;Ning X;Wang R;Luo J;He S
通讯作者：
He S

A new method for removing artifacts from recordings of the electrically evoked compound action potential: Single-pulse stimulation.

一种从电诱发复合动作电位记录中去除伪影的新方法：单脉冲刺激。