Northwestern University Molecular and Translational Cardiovascular Training Program

这项建议是西北大学心血管基础研究培训的新应用 范伯格医学院。我们见证了科学知识的快速发展 心血管(CV)疾病，这为新的 这些发现可能会带来更好的治疗选择。西北大学的办学目标 分子和转化性心血管培训计划(NMTCTP)是为一项独特的 旨在培养对简历感兴趣的下一代研究人员的全面计划 生理学和疾病。这是第一次提出提案请求，此时正值经济大幅和持续增长之际 在心血管研究和范伯格医学院的研究事业中。NMTCTP为 独一无二的是，它将包括三个不同的CV集中领域：基因组学/蛋白质组学，生物学 血管和新陈代谢。该计划将包括23名杰出的研究科学家作为导师，他们已经 有丰富的博士后和博士后培训经验，并与其他导师或科学家合作 国内和国际上，以及一位统计导师。我们的计划还将利用一组 研究人员将担任翻译顾问，以帮助我们的指导对象了解以下临床影响 他们的基本科学发现，并为他们提供职业建议。这将提供一个培训环境 这使受训者能够获得他们成为下一个所需的全方位的接触和培训 一代心血管疾病的研究人员和领导者。目前还没有一个计划强调基本的 西北大学心血管疾病的发病机制。博士前实习生将来自德里斯基尔 生命科学研究生课程(DGP)和医学科学家课程(MSTP)，博士后 受训人员将成为博士和医学博士研究员。该计划将定期进行严格的评估，使用 不同的机制，包括由执行委员会、外部咨询委员会、 通过跟踪以前受训人员的进展情况，对受训人员进行评估。我们已经开始了简历教学课程和一个 西北简历研究日，它将突出我们学员的成就，并将允许近距离 我们的学员和受邀演讲者之间的互动。NMTCTP还制定了以下机制 促进我们的受训人员与其他机构的科学家之间的互动(通过支持我们的受训人员 参加国家会议)，并允许他们邀请和主持外部演讲者。该程序请求 在第一年每年支持2名博士后研究员和1名博士后学生，以及4名博士后和 2名博士前实习生，为期2-5年。每名实习生将获得为期两年的支持。资金来源 NMTCTP将为西北大学提供刺激跨学科合作的手段，并培训 下一代科学家将工作在简历研究的前沿，并了解 他们的发现的翻译含义。

This proposal is a new application for basic cardiovascular Research Training at Northwestern University Feinberg School of Medicine. We have witnessed rapid advances in the scientific knowledge in cardiovascular (CV) disease in the past few years, and this has created unparalleled opportunities for new discoveries that can potentially lead to better treatment options. The objective of the Northwestern University Molecular and Translational Cardiovascular Training Program (NMTCTP) is to request funding for a unique and comprehensive program that is designed to train the next generation of researchers interested in CV physiology and disease. This first time proposal request comes at a time of substantial and sustained growth in cardiovascular research and the research enterprise of the Feinberg School of Medicine. NMTCTP is unique in that it will encompass three distinct areas of CV concentration: genomics/proteomics, biology of vessels, and metabolism. The program will include 23 outstanding research scientists as mentors, who have extensive experience in pre- and postdoctoral training and have collaborated with other mentors or scientists nationally and internationally, and a statistical mentor. Our program will also use the expertise of a group of investigators who will serve as translational advisors to assist our mentees with the clinical implications of their basic science findings, and to provide career advice to them. This will provide a training environment that enables trainees to obtain the full range of exposure and training they need to become the next generation of researchers and leaders in CV disease. There is no current program that emphasizes the basic mechanisms of CV disease at Northwestern University. Predoctoral trainees will come from the Driskill Graduate Program in Life Sciences (DGP) and the Medical Scientist Program (MSTP), while postdoctoral trainees will be PhD and MD research fellows. The program will be regularly and rigorously evaluated using different mechanisms, including evaluation by an Executive Committee, an External Advisory Committee, the trainees, and by tracking the progress of former trainees. We have started a CV didactic course and a Northwestern CV Research Day, which will highlight the accomplishments of our trainees and will allow close interaction between our mentees and the invited speaker. NMTCTP also has mechanisms in place to catalyze interactions between our trainees with scientists at other institutions (by supporting our trainees to attend national conferences) and by allowing them to invite and host outside speakers. The program requests support for 2 postdoctoral fellows and 1 predoctoral student per year in the first year, and 4 postdoctoral and 2 predoctoral trainees in years 2-5 of the grant. Each trainee will be supported for a total of 2 years. Funding of NMTCTP will provide Northwestern with the means to stimulate cross-disciplinary collaboration, and train the next generation of scientists that will work at the forefront of CV research, and understand the translational implication of their findings.