Northwestern University Molecular and Translational Cardiovascular Training Program

西北大学分子与转化心血管培训项目

• 批准号: 10197196
• 负责人: Elizabeth M McNally
• 金额: $ 33.5万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197196
• 关键词: Cardiovascular system; Molecular; Training Programs; Universities

This proposal is a new application for basic cardiovascular Research Training at Northwestern University Feinberg School of Medicine. We have witnessed rapid advances in the scientific knowledge in cardiovascular (CV) disease in the past few years, and this has created unparalleled opportunities for new discoveries that can potentially lead to better treatment options. The objective of the Northwestern University Molecular and Translational Cardiovascular Training Program (NMTCTP) is to request funding for a unique and comprehensive program that is designed to train the next generation of researchers interested in CV physiology and disease. This first time proposal request comes at a time of substantial and sustained growth in cardiovascular research and the research enterprise of the Feinberg School of Medicine. NMTCTP is unique in that it will encompass three distinct areas of CV concentration: genomics/proteomics, biology of vessels, and metabolism. The program will include 23 outstanding research scientists as mentors, who have extensive experience in pre- and postdoctoral training and have collaborated with other mentors or scientists nationally and internationally, and a statistical mentor. Our program will also use the expertise of a group of investigators who will serve as translational advisors to assist our mentees with the clinical implications of their basic science findings, and to provide career advice to them. This will provide a training environment that enables trainees to obtain the full range of exposure and training they need to become the next generation of researchers and leaders in CV disease. There is no current program that emphasizes the basic mechanisms of CV disease at Northwestern University. Predoctoral trainees will come from the Driskill Graduate Program in Life Sciences (DGP) and the Medical Scientist Program (MSTP), while postdoctoral trainees will be PhD and MD research fellows. The program will be regularly and rigorously evaluated using different mechanisms, including evaluation by an Executive Committee, an External Advisory Committee, the trainees, and by tracking the progress of former trainees. We have started a CV didactic course and a Northwestern CV Research Day, which will highlight the accomplishments of our trainees and will allow close interaction between our mentees and the invited speaker. NMTCTP also has mechanisms in place to catalyze interactions between our trainees with scientists at other institutions (by supporting our trainees to attend national conferences) and by allowing them to invite and host outside speakers. The program requests support for 2 postdoctoral fellows and 1 predoctoral student per year in the first year, and 4 postdoctoral and 2 predoctoral trainees in years 2-5 of the grant. Each trainee will be supported for a total of 2 years. Funding of NMTCTP will provide Northwestern with the means to stimulate cross-disciplinary collaboration, and train the next generation of scientists that will work at the forefront of CV research, and understand the translational implication of their findings.

这份提案是西北大学基础心血管研究培训的新申请 范伯格医学院。我们目睹了科学知识的迅速发展， 心血管（CV）疾病在过去几年中，这创造了前所未有的机会， 这些发现可能会带来更好的治疗选择。西北大学的目标 分子和转化心血管培训计划（NMTCTP）是为了申请资金， 该计划旨在培养下一代对CV感兴趣的研究人员 生理学和疾病。这是第一次提出建议要求，在一个时间的实质性和持续增长 心血管研究和范伯格医学院的研究企业。NMTCTP是 它的独特之处在于它将涵盖CV浓度的三个不同领域：基因组学/蛋白质组学，生物学， 血管和新陈代谢。该计划将包括23名杰出的研究科学家作为导师，他们 在博士前和博士后培训方面有丰富的经验，并与其他导师或科学家合作 在国内和国际上，以及一个统计导师。我们的计划还将利用一组专业知识， 研究人员将作为翻译顾问，协助我们的学员了解以下方面的临床意义： 他们的基础科学发现，并为他们提供职业建议。这将提供一个培训环境 使学员能够获得成为下一个 CV疾病的一代研究人员和领导者。目前没有一个方案强调基本的 西北大学的CV疾病机制。博士前培训生将来自德里斯基尔 生命科学研究生课程（DGP）和医学科学家课程（MSTP），而博士后 学员将是博士和医学博士研究员。该计划将定期进行严格的评估， 不同的机制，包括执行委员会、外部咨询委员会、 学员，并通过跟踪前学员的进展。我们已经开始了一个简历教学课程， 西北CV研究日，这将突出我们的学员的成就，并将允许关闭 我们的学员和受邀演讲者之间的互动。NMTCTP还建立了机制， 促进我们的学员与其他机构的科学家之间的互动（通过支持我们的学员， 参加国家会议），并允许它们邀请和接待外部发言者。程序请求 第一年每年资助2名博士后研究员和1名博士前学生， 2名博士前实习生在第2-5年的赠款。每名受训人员将得到总共两年的支助。资金 NMTCTP将为西北大学提供促进跨学科合作的手段，并培训 下一代科学家将在CV研究的最前沿工作，并了解 他们的发现的翻译含义。

项目成果

Aortic annular dimensions by non-contrast MRI using k-t accelerated 3D cine b-SSFP in pre-procedural assessment for transcatheter aortic valve implantation: a technical feasibility study.

• DOI: 10.1007/s10554-020-02038-6
• 发表时间: 2021-03
• 期刊: The international journal of cardiovascular imaging
• 作者: Aouad P;Jarvis KB;Botelho MF;Serhal A;Blaisdell J;Collins L;Giri S;Kim D;Markl M;Ricciardi MJ;Davidson CJ;Collins J;Carr J
• 通讯作者: Carr J

Risk Differences in Secondary Prevention Patients Who Present With Acute Coronary Syndrome and Implications of Guideline-Directed Cholesterol Management.

• DOI: 10.1016/j.amjcard.2020.07.039
• 发表时间: 2020-10-15
• 期刊: The American journal of cardiology
• 作者: Kong NW;Bavishi A;Amaral AP;Tibrewala A;Jivan A;Silberman P;Stone NJ
• 通讯作者: Stone NJ