Administrative Core

抽象核心A 老年科学假说是基于这样一种观察，即健康寿命在生命接近尾声时通常会下降 表现为单一的与年龄相关的疾病，随后与年龄相关的并发症迅速积累 在相对较短的时间内。根据这一假设，在不治疗上述任何一种情况下 治疗衰老的基本生物学只会导致它被另一种生物学所取代。虽然肺炎 导致老年人死亡率过高，大多数获得现代医疗保健的老年患者存活下来 然而，在出院后的一年里，这些老年肺炎幸存者患肺炎的风险增加。 发生与年龄相关的疾病，包括持续性肺损伤，骨骼肌功能障碍导致 行动不便、心肌梗死、慢性肾脏疾病、痴呆症和认知障碍。因此， 肺炎是一种复杂的发病率，限制了生命末期的健康寿命。在第一个周期中 对于这一奖项，我们使用了无偏见的转录组和蛋白质组方法来表明与年龄相关的韧性可以 通过激活整合应激反应部分抑制线粒体新陈代谢来恢复 转录因子4(ATF4)。核心A将协助PPG调查人员测试这一核心假设 这一PPG通过一系列高度集成和创新的实验，专注于五个具体目标： 具体目标1.支持项目调查人员、核心领导之间的沟通，协作 调查人员以及内部和外部咨询委员会成员。 具体目标2.为各国之间分享材料和传播信息提供一个结构 项目调查员、核心领导及其合作者。 具体目标3.向项目和核心领导提供财务和监管监督，并协调 他们与机构核心服务的互动。 具体目标4.通过出版物传播方案项目调查人员的发现， 向其他机构和其他调查人员介绍和分享试剂和技术。 具体目标5.营造协作的跨学科研究和指导环境 学生、博士后研究员和研究人员。

ABSTRACT CORE A The Geroscience hypothesis is based on the observation that healthspan decline toward the end of life often presents with a single age-related illness that is followed by the rapid accumulation of age-related complications over a relatively short period of time. According to this hypothesis, treating any one of these conditions without treating the fundamental biology of aging will only result in its substitution by another. Although pneumonia causes excess mortality in older people, most elderly patients with access to modern health care survive However, in the year after hospital discharge these older pneumonia survivors have an increased risk of developing age-related disorders including persistent lung injury, skeletal muscle dysfunction leading to immobility, myocardial infarction, chronic kidney disease, dementia and cognitive impairment. As such, pneumonia is a gateway for the compounding morbidity that limits healthspan at the end of life. In the first cycle of this award, we used unbiased transcriptomic and proteomic approaches to suggest age-related resilience can be restored by partial inhibition of mitochondrial metabolism through the integrated stress response via Activating Transcription Factor 4 (ATF4). Core A will assist the PPG investigators as they test this central hypothesis of this PPG through a highly integrated and innovative set of experiments by focusing on five Specific Aims: Specific Aim 1. To support communication between the Project Investigators, the Core Leaders, Collaborating investigators, and the Internal and External Advisory Committee members. Specific Aim 2. To provide a structure for the sharing of materials and dissemination of information between the Project Investigators, Core Leaders and their Collaborators. Specific Aim 3. To provide financial and regulatory oversight to the Project and Core Leaders and coordinate their interactions with Institutional Core Services. Specific Aim 4. To disseminate the discoveries made by the program project investigators through publications, presentations and the sharing of reagents and techniques to other institutions and other investigators. Specific Aim 5. To foster an environment of collaborative interdisciplinary research and mentoring of students, post-doctoral fellows and investigators.