Advisory Committees

咨询委员会

• 批准号: 7691385
• 负责人: Janan T. EPPIG
• 金额: $ 3.93万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7691385
• 关键词: Advisory Committees; Bioinformatics; Biological; Biological Models; Biology; Collaborations; Communities; Community Outreach; Computer software; Computers; Consensus; Controlled Vocabulary; Data; Data Analyses; Data Set; Databases; Disease; Disease model; Funding; Future; Gene Mutation; Genes; Genetic; Genetic Variation; Genome; Genomics; Goals; Grouping; Human Biology; International; Link; Mammals; Maps; Memory; Mission; Modeling; Mus; Phenotype; Process; Program Evaluation; Proteins; Purpose; Quantitative Trait Loci; Recruitment Activity; Reporting; Research; Resources; Rotation; Schedule; Scientist; System; Work; comparative; data management; day; design; genome database; member; mouse genome; programs; software development; symposium; tool; trait; user-friendly

The primary mission of the Mouse Genome Database (MGD) is to facilitate the use of the mouse as a model system for understanding human biology and disease. To achieve this objective we: 1) create and maintain an integrated representation of mouse genetic, genomic, and phenotypic data; 2) expertly curate and annotate data to develop definitive reference data sets and consensus views; 3) gather and synthesize comparative genomic data between mouse and other mammals; 4) maintain a rich set of links and collaborations with other bioinformatics resources; 5) develop and support analysis and data submission tools; 6) develop user-friendly interfaces for public access to mouse genomic data; 7) provide extensive technical support for our community of database users; 8) actively participate in a coordinate with the global research community. This renewal proposes a Program revolving around the themes of sequences, genes, and phenotypes. Sequences and Sequence Maps: We will enhance the representation of sequence data and maps. Sequences and sequence feature maps will be integrated into MGD, gene models will be collected to biological context, and map of objects will become an important mechanism for viewing and exploring MGD. Genes and Gene Products: We will continue curation of MGD's core data and expand these to include gene products and gene groupings. Core data include information about genes and variants, function and process, and mammalian homologies. Phenotypes: We will enhance the representation of phenotypes in MGD, develop controlled vocabularies for describing phenotypes, and gather and annotate phenotype data. Phenotypic data about single gene mutations, multigenic traits, QTL, disease models and strains data will be emphasized. Database and Software Development: We will provide a unified software effort and design and implement database and software changes to MGD to achieve the overall goals of the Program Project. Community Outreach: As the scientific community database for the mouse, MGD places high priority on community involvement. We provide technical support for our database users and encourage community input, submissions, annotations, and collaborations.

小鼠基因组数据库（Mouse Genome Database， MGD）的主要任务是促进将小鼠作为理解人类生物学和疾病的模型系统。为了实现这一目标，我们：1)创建并维护小鼠遗传、基因组和表型数据的集成表示；2)熟练地整理和注释数据，以形成明确的参考数据集和共识观点；3)收集和合成小鼠与其他哺乳动物的比较基因组数据；4)与其他生物信息学资源保持丰富的联系和合作；开发和支持分析和数据提交工具；6)开发用户友好界面，供公众访问小鼠基因组数据；7)为数据库用户社区提供广泛的技术支持；8)积极参与与全球研究界的协调。这个更新提出了一个围绕序列，基因和表型主题的程序。序列和序列图：我们将加强序列数据和序列图的表示。序列和序列特征图谱将被整合到MGD中，基因模型将被收集到生物学背景中，物体图谱将成为观察和探索MGD的重要机制。基因和基因产物：我们将继续管理MGD的核心数据，并将其扩展到包括基因产物和基因分组。核心数据包括有关基因和变异、功能和过程以及哺乳动物同源性的信息。表型：我们将增强表型在MGD中的代表性，开发用于描述表型的受控词汇表，并收集和注释表型数据。将着重介绍单基因突变、多基因性状、QTL、疾病模型和菌株的表型数据。数据库和软件开发：我们将为MGD提供统一的软件工作，并设计和实施数据库和软件更改，以实现计划项目的总体目标。社区外展：作为老鼠的科学社区数据库，MGD高度重视社区参与。我们为数据库用户提供技术支持，并鼓励社区输入、提交、注释和协作。