Lesion Analysis/Biostatistics Core

病变分析/生物统计学核心

• 批准号: 10197187
• 负责人: NAN WANG
• 金额: $ 32.27万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197187
• 关键词: Apoptosis; Arterial Fatty Streak; Atherosclerosis; Automobile Driving; Biological Assay; Biometry; Biostatistics Core; Cell Adhesion; Cells; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chromatin; Coronary heart disease; Data Analyses; Development; Diabetes Mellitus; Disease; Ensure; Experimental Designs; Gene Expression Profiling; Genomic approach; Heart Diseases; Human; In Situ; Incidence; Inflammation; Insulin Resistance; Lesion; Life Expectancy; Link; Obesity; Obesity Epidemic; Public Health; Reporting; Research Design; atherogenesis; experimental analysis; genome-wide; laser capture microdissection; power analysis; professor; stroke incidence; transcriptomics

Core A – Project Summary/Abstract The Lesion Analysis/ Biostatistics Core will continue to provide support to each of the three projects in study design and assessment of atherosclerotic lesion development. The Core ensures consistent quantitative and qualitative assessment of atherosclerotic lesions, adequately powered experimental design and appropriate analysis of experimental results across all three projects of the PPG. Specifically, the Core will provide state-of-the-art expertise in A) quantification of atherosclerotic lesions; B) qualitative assessment of lesion composition; C) apoptosis and in situ efferocytosis assays; D) markers of cell adhesion and inflammation; E) laser-capture microdissection (LCM) for cell-specific quantitative gene expression analyses; and F) biostatistical support including study design and power analyses. In addition, the Core will provide biostatistical support for genome-wide transcriptomic and chromatin analyses via the expertise of Dr. Ying Wei, Professor of Biostatistics.

核心A--项目摘要/摘要 损害分析/生物统计核心将继续为三个中心中的每一个提供支持 动脉粥样硬化病变发展的研究设计和评估项目。《核心》 确保对动脉粥样硬化病变进行一致的定量和定性评估， 充分动力的实验设计和实验结果的适当分析 在PPG的所有三个项目中。具体地说，核心将提供最先进的专业知识 A)动脉粥样硬化病变的量化；B)病变成分的定性评估； C)细胞凋亡和原位胞吐试验；D)细胞黏附和炎症标记物；E) 激光捕获显微切割(LCM)用于细胞特异性定量基因表达分析；以及 F)生物统计支持，包括研究设计和力量分析。此外，核心将 为全基因组转录和染色质分析提供生物统计学支持 生物统计学教授应伟博士的专业知识。