Lesion Analysis/Biostatistics Core

核心A -项目总结/摘要 病变分析/生物统计学核心将继续为三个中心提供支持。 研究设计和评估动脉粥样硬化病变发展的项目。核心 确保对动脉粥样硬化病变进行一致的定量和定性评估， 充分把握的实验设计和适当的实验结果分析 PPG的所有三个项目。具体而言，核心将提供最先进的专业知识， A）动脉粥样硬化病变的定量; B）病变组成的定性评估; C）细胞凋亡和原位细胞凋亡测定; D）细胞粘附和炎症的标志物; E） 用于细胞特异性定量基因表达分析的激光捕获显微切割（LCM）;以及 F）生物统计学支持，包括研究设计和功效分析。此外，核心将 为全基因组转录组和染色质分析提供生物统计支持， 生物统计学教授魏英博士的专业知识。

Core A – Project Summary/Abstract The Lesion Analysis/ Biostatistics Core will continue to provide support to each of the three projects in study design and assessment of atherosclerotic lesion development. The Core ensures consistent quantitative and qualitative assessment of atherosclerotic lesions, adequately powered experimental design and appropriate analysis of experimental results across all three projects of the PPG. Specifically, the Core will provide state-of-the-art expertise in A) quantification of atherosclerotic lesions; B) qualitative assessment of lesion composition; C) apoptosis and in situ efferocytosis assays; D) markers of cell adhesion and inflammation; E) laser-capture microdissection (LCM) for cell-specific quantitative gene expression analyses; and F) biostatistical support including study design and power analyses. In addition, the Core will provide biostatistical support for genome-wide transcriptomic and chromatin analyses via the expertise of Dr. Ying Wei, Professor of Biostatistics.