Core K - Substance Use Research Core

项目概要 不健康物质使用 (SU) 是美国死亡和残疾的主要原因，也是一种常见的合并症 艾滋病毒感染者 (PLWH) 的人数，其中艾滋病毒感染始终与延迟接触艾滋病毒有关 护理、护理保留率较差、ART 依从性较低以及病毒和免疫结果较差。因此，艾滋病毒 研究必须使用严格的方法来解释研究设计和分析中的 SU 并测试 SU 干预措施。物质使用研究核心 (SURC) 是该研究的一项创新性和决定性特征 普罗维登斯/波士顿艾滋病研究中心 (P/B CFAR) 将促进 SU/HIV 研究和创新 加强 P/B CFAR 解决弱势群体艾滋病毒问题的使命。为支持发展 SURC 开展了基础、临床和转化研究，以解决 SU 对 HIV 流行的影响 以下具体目标： 1) 为 CFAR 研究人员提供开发研究项目的专业知识 解决国内和全球在 SU/HIV 优先问题方面的差距。 SURC 将确保 CFAR 项目 适当考虑并纳入 SU 对研究结果的影响；连接 SU 调查员和 HIV 研究人员通过正式和非正式的机会开发合作项目；并与 CFAR 合作 研究人员制定创新且科学合理的 SU/HIV 研究问题。 2) 支持恒虚警 研究人员在进行严格的 HIV 研究时将 SU 考虑在内。 SURC将提供服务 帮助调查人员确定最合适的工具来评估消费、严重程度、后果和 SU 的相关耻辱，并提供有关使用经过验证的自我报告量表、结构化的培训 访谈、实验室和生态瞬时评估以及 SU 的生物测试。 SURC 有 SU 药物治疗、行为干预、移动健康 (mHealth) 应用和慢性病方面的专业知识 疾病管理。该领域的核心服务将包括 SU 干预选择和培训、保真度 评估技术、干预手册以及对新人群的适应。市委还将审查 相关的 IRB 协议，并就对 SU 研究特别重要的伦理问题提供指导，例如 保密保护并向积极吸毒者提供补偿。提供的服务 SURC 将确保 CFAR 调查人员具备最佳能力来开展考虑到的研究项目 并解决 SU 对艾滋病毒预防、艾滋病毒护理连续体和艾滋病毒合并症的主要影响。

PROJECT SUMMARY Unhealthy substance use (SU) is a leading cause of death and disability in the US and a common comorbidity of people living with HIV (PLWH), among whom it is consistently associated with delays to engagement in HIV care, worse retention in care, lower ART adherence, and worse viral and immunologic outcomes. Therefore, HIV research must use rigorous methods to account for SU in study designs and analyses and to test SU interventions. The Substance Use Research Core (SURC) is an innovative and defining feature of the Providence/Boston Center for AIDS Research (P/B CFAR) that will catalyze innovations in SU/HIV research and strengthen the P/B CFAR's mission to address HIV in vulnerable populations. To support the development of basic, clinical, and translational research that addresses the impact of SU on the HIV epidemic, the SURC has the following Specific Aims: 1) To provide CFAR investigators expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally. The SURC will ensure that CFAR projects appropriately consider and incorporate the impact of SU on study outcomes; connect SU investigators and HIV investigators through formal and informal opportunities to develop collaborative projects; and work with CFAR investigators to formulate innovative and scientifically sound SU/HIV research questions. 2) To support CFAR investigators in the conduct of rigorous HIV research that takes SU into account. The SURC will provide services to help investigators identify the most appropriate tools to assess consumption, severity, consequences and associated stigma of SU as well as provide training on utilization of validated self-report scales, structured interviews, laboratory and ecological momentary assessments, and biological tests of SU. The SURC has expertise on SU pharmacotherapy, behavioral interventions, mobile health (mHealth) applications, and chronic disease management. Core services in this realm will include SU intervention selection and training, fidelity assessment techniques, intervention manuals, and adaptation to new populations. The SURC will also review relevant IRB protocols and provide guidance on ethical issues of particular importance to SU research, such as confidentiality protections and providing compensation to people actively using drugs. The services provided by the SURC will ensure that CFAR investigators are optimally equipped to pursue research projects that consider and address the major impact of SU on HIV prevention, the HIV Care Continuum, and HIV comorbidities.