Core K - Substance Use Research Core

核心 K - 药物使用研究核心

• 批准号: 10454399
• 负责人: Karsten Lunze
• 金额: $ 22.49万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10454399
• 关键词: AIDS prevention; Accounting; Acquired Immunodeficiency Syndrome; Address; Adherence; Applications Grants; Basic Science; Behavior Therapy; Behavioral Sciences; Biological Testing; Boston; Cardiovascular Diseases; Caring; Cause of Death; Chronic Disease; Clinical; Clinical Research; Consultations; Consumption; Continuity of Patient Care; Data Analyses; Development; Disease Management; Drug usage; Ecological momentary assessment; Ensure; Epidemic; Ethical Issues; Ethics; Financial compensation; Functional disorder; Funding; Goals; HIV; HIV Infections; Heavy Drinking; Immunologics; Institution; Institutional Review Boards; Intervention; Interview; Knowledge; Laboratories; Leadership; Life; Liver diseases; Longitudinal Studies; Malignant Neoplasms; Manuals; Manuscripts; Medicine; Methods; Mission; Mobile Health Application; National Institute on Alcohol Abuse and Alcoholism; Neurocognitive; Neurokinin A; Outcome; Outcome Study; Patient Self-Report; Persons; Pharmacotherapy; Population; Protocols documentation; Public Health Practice; Publications; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Services; Severities; Site; Smoking; Structure; Techniques; Testing; Training; Translational Research; Treatment outcome; Universities; Viral; Vulnerable Populations; Work; addiction; alcohol research; alcohol tobacco and other drug use; base; cocaine use; comorbidity; disability; injection drug use; innovation; mortality risk; social stigma; sound; stimulant use; substance use; tool; transmission process; treatment disparity

PROJECT SUMMARY Unhealthy substance use (SU) is a leading cause of death and disability in the US and a common comorbidity of people living with HIV (PLWH), among whom it is consistently associated with delays to engagement in HIV care, worse retention in care, lower ART adherence, and worse viral and immunologic outcomes. Therefore, HIV research must use rigorous methods to account for SU in study designs and analyses and to test SU interventions. The Substance Use Research Core (SURC) is an innovative and defining feature of the Providence/Boston Center for AIDS Research (P/B CFAR) that will catalyze innovations in SU/HIV research and strengthen the P/B CFAR's mission to address HIV in vulnerable populations. To support the development of basic, clinical, and translational research that addresses the impact of SU on the HIV epidemic, the SURC has the following Specific Aims: 1) To provide CFAR investigators expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally. The SURC will ensure that CFAR projects appropriately consider and incorporate the impact of SU on study outcomes; connect SU investigators and HIV investigators through formal and informal opportunities to develop collaborative projects; and work with CFAR investigators to formulate innovative and scientifically sound SU/HIV research questions. 2) To support CFAR investigators in the conduct of rigorous HIV research that takes SU into account. The SURC will provide services to help investigators identify the most appropriate tools to assess consumption, severity, consequences and associated stigma of SU as well as provide training on utilization of validated self-report scales, structured interviews, laboratory and ecological momentary assessments, and biological tests of SU. The SURC has expertise on SU pharmacotherapy, behavioral interventions, mobile health (mHealth) applications, and chronic disease management. Core services in this realm will include SU intervention selection and training, fidelity assessment techniques, intervention manuals, and adaptation to new populations. The SURC will also review relevant IRB protocols and provide guidance on ethical issues of particular importance to SU research, such as confidentiality protections and providing compensation to people actively using drugs. The services provided by the SURC will ensure that CFAR investigators are optimally equipped to pursue research projects that consider and address the major impact of SU on HIV prevention, the HIV Care Continuum, and HIV comorbidities.

项目摘要 不健康物质使用（SU）是美国死亡和残疾的主要原因，也是常见的合并症 艾滋病毒感染者（PLWH），其中它始终与艾滋病毒感染者的延迟接触有关 护理，更差的护理保留，更低的ART依从性和更差的病毒和免疫结果。因此，HIV 研究必须使用严格的方法来解释研究设计和分析中的SU，并测试SU 干预措施。物质使用研究核心（SURC）是一个创新和定义的功能， 普罗维登斯/波士顿艾滋病研究中心（P/B CFAR）将促进SU/HIV研究的创新， 加强P/B CFAR的使命，以解决弱势群体中的艾滋病毒问题。支持发展 基础，临床和转化研究，解决了SU对HIV流行的影响，SURC已经 以下具体目标：1）为CFAR调查人员提供开发研究项目的专业知识， 解决国内和全球艾滋病毒特别股优先事项方面的差距。分区域资源中心将确保经常资源报告项目 适当考虑并纳入SU对研究结局的影响;将SU研究者和HIV 调查人员通过正式和非正式的机会开发合作项目;并与CFAR合作 研究人员制定创新和科学合理的SU/HIV研究问题。2)支持CFAR 研究人员在进行严格的艾滋病毒研究时考虑到了SU。SURC将提供服务 帮助调查人员确定最适当的工具，以评估消费，严重程度，后果， 相关的污名SU，以及提供培训，利用经验证的自我报告量表，结构化 访谈，实验室和生态瞬时评估，以及SU的生物学测试。SURC已 SU药物治疗、行为干预、移动的健康（mHealth）应用和慢性 疾病管理。这一领域的核心服务将包括SU干预选择和培训， 评估技术、干预手册和适应新人口。SURC还将审查 相关的IRB方案，并提供对SU研究特别重要的伦理问题的指导，例如 保密保护和向积极使用毒品的人提供补偿。提供的服务 分区域资源中心将确保CFAR调查人员拥有最佳装备，以开展研究项目，这些项目考虑到 并解决SU对艾滋病毒预防、艾滋病毒护理连续体和艾滋病毒合并症的主要影响。