Core K - Substance Use Research Core

项目总结 不健康的物质使用(SU)在美国是导致死亡和残疾的主要原因，也是一种常见的共病 艾滋病毒携带者(PLWH)，其中它始终与延迟接触艾滋病毒有关 护理，更差的护理保持，更低的抗逆转录病毒治疗依从性，以及更差的病毒和免疫结果。因此，艾滋病毒 研究必须使用严格的方法来说明研究设计和分析中的SU，并测试SU 干预措施。物质使用研究核心(SURC)是创新的和定义的特征 普罗维登斯/波士顿艾滋病研究中心(P/B CFAR)，将催化SU/HIV研究和创新 加强P/B CFAR在脆弱人群中解决艾滋病毒问题的使命。支持……发展 基础、临床和转化性研究，以解决SU对HIV流行的影响，Surc有 以下具体目标：1)向CFAR调查员提供制定下列研究项目的专门知识 解决国内和全球艾滋病病毒/艾滋病毒优先问题上的差距。该基金将确保CFAR项目 适当考虑并纳入SU对研究结果的影响；将SU调查人员与艾滋病毒联系起来 调查人员通过正式和非正式机会制定合作项目；并与CFAR合作 研究人员制定创新的、科学合理的SU/HIV研究问题。2)支持CFAR 调查人员在进行严格的艾滋病毒研究时考虑到了苏。SURAC将提供服务 帮助调查人员确定最合适的工具来评估消费、严重性、后果和 与SU相关的耻辱以及提供使用有效的自我报告量表的培训，结构化的 访谈，实验室和生态瞬时评估，以及对SU的生物学测试。外科医生已经有了 在SU药物治疗、行为干预、移动健康(MHealth)应用和慢性疾病方面的专业知识 疾病管理。该领域的核心服务将包括SU干预选拔和培训、保真 评估技术、干预手册和对新人口的适应。海军部还将审查 并就对SU研究特别重要的伦理问题提供指导，例如 保密保护，并为活跃吸毒者提供赔偿。由提供的服务 SURC将确保CFAR调查人员拥有最佳装备，以开展考虑以下因素的研究项目 并阐述了SU在艾滋病毒预防、艾滋病毒护理连续性和艾滋病毒共生方面的主要影响。

PROJECT SUMMARY Unhealthy substance use (SU) is a leading cause of death and disability in the US and a common comorbidity of people living with HIV (PLWH), among whom it is consistently associated with delays to engagement in HIV care, worse retention in care, lower ART adherence, and worse viral and immunologic outcomes. Therefore, HIV research must use rigorous methods to account for SU in study designs and analyses and to test SU interventions. The Substance Use Research Core (SURC) is an innovative and defining feature of the Providence/Boston Center for AIDS Research (P/B CFAR) that will catalyze innovations in SU/HIV research and strengthen the P/B CFAR's mission to address HIV in vulnerable populations. To support the development of basic, clinical, and translational research that addresses the impact of SU on the HIV epidemic, the SURC has the following Specific Aims: 1) To provide CFAR investigators expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally. The SURC will ensure that CFAR projects appropriately consider and incorporate the impact of SU on study outcomes; connect SU investigators and HIV investigators through formal and informal opportunities to develop collaborative projects; and work with CFAR investigators to formulate innovative and scientifically sound SU/HIV research questions. 2) To support CFAR investigators in the conduct of rigorous HIV research that takes SU into account. The SURC will provide services to help investigators identify the most appropriate tools to assess consumption, severity, consequences and associated stigma of SU as well as provide training on utilization of validated self-report scales, structured interviews, laboratory and ecological momentary assessments, and biological tests of SU. The SURC has expertise on SU pharmacotherapy, behavioral interventions, mobile health (mHealth) applications, and chronic disease management. Core services in this realm will include SU intervention selection and training, fidelity assessment techniques, intervention manuals, and adaptation to new populations. The SURC will also review relevant IRB protocols and provide guidance on ethical issues of particular importance to SU research, such as confidentiality protections and providing compensation to people actively using drugs. The services provided by the SURC will ensure that CFAR investigators are optimally equipped to pursue research projects that consider and address the major impact of SU on HIV prevention, the HIV Care Continuum, and HIV comorbidities.