Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders

摘要 睡眠和昼夜节律紊乱对公共卫生有重大影响。几乎所有的睡眠和 昼夜节律是遗传的，就像普通的睡眠和昼夜节律紊乱一样。因此，有一个重大的机会 研究睡眠/昼夜节律和不同睡眠障碍的遗传基础。基因组方法， 包括开发新的生物标志物，是另一个机会领域。虽然这些主要的科学 机会是存在的，但我们没有必要的科学劳动力来解决这些问题。为了解决这个 根据需要，在睡眠和昼夜节律的遗传/基因组学方面建立了多机构培训赠款 紊乱它需要一个国家的视角，而不是单一的机构视角。该计划是由教师在 宾夕法尼亚大学，拥有最先进的研究培训基础设施。的网站 研究员在约翰霍普金斯大学、密歇根大学和斯坦福大学接受培训。一 已招聘多学科、有才能的教员提供培训。这包括专家在不同的睡眠 人类遗传学中的疾病，基因组方法，包括RNA测序，以及多模型系统的使用 比如斑马鱼和老鼠。后者允许受训者评估所鉴定的基因变异的功能作用 在人类研究中。该方案协调了所有受训者参加的活动。其中包括研究工作- 正在进行的会谈、赠款讲习班和关于睡眠和昼夜节律紊乱的遗传学/基因组学的讲座。的 项目共招收了8名优秀的博士、博士博士后研究生，其中4名已提交 职业发展赠款。所有进入该计划的人都将继续从事生物医学研究， 学术环境。

ABSTRACT Sleep and circadian disorders have a major impact on public health. Almost all aspects of sleep and circadian rhythm are heritable as are common sleep and circadian disorders. Thus, there is a major opportunity to study the genetic basis of sleep/circadian rhythm and different sleep disorders. Genomic approaches, including development of novel biomarkers, are another area of opportunity. While these major scientific opportunities are available, we do not have the scientific workforce necessary to address them. To address this need, a multi-institutional training grant has been established in genetic/genomics of sleep and circadian disorders. It takes a national, rather than single institutional, perspective. The program is led by faculty at the University of Pennsylvania, which has the most advanced infrastructure for research training. The sites that fellows train at are Johns Hopkins University, University of Michigan and Stanford University. A multidisciplinary, talented faculty has been recruited to provide training. This includes experts in different sleep disorders, in human genetics, in genomic approaches, including RNA seq, and use of multiple model systems such as zebrafish and mice. The latter allows trainees to evaluate the functional role of gene variants identified in human studies. The program has coordinated events that all trainees attend. These include research work- in-progress talks, a grant workshop and lectures on genetics/genomics of sleep and circadian disorders. The program has recruited 8 outstanding MD and PhD postdoctoral trainees, four of whom have already submitted career development grants. All individuals who have entered the program remain in biomedical research in academic settings.