Clinical Research Design, Epidemiology and Biostatistics Core

项目摘要：设计、流行病学和生物统计学核心 临床研究设计的总体目标，流行病学和生物统计学的关键组成部分 路易斯安那州临床和转化科学中心(LA CATS)的活动(DEB KCA)是为了确保所有 在洛杉矶猫的权限内进行的临床和翻译研究符合最高科学研究 研究设计和分析的标准。在最初的融资期间，我们成功地利用了现有的 开发计划署从主要合作机构的教职人员那里获得专门知识，并实施了一个综合的发展计划署 支持网络，现在可供所有参与洛杉矶CATS机构的调查人员使用。我们现在提供 为全州的Cobre/INBRE学员、我们的路线图和功勋公司提供DeB服务和咨询 学者，以及其他寻求将他们的研究扩展到翻译努力的调查人员。为了满足 需要更多的生物信息学专业知识，DEB KCA主任领导创建了东南 信息学联盟(SIC)，以确定具体需求，制定共享资源和工作的方法 共同推动生物信息学在临床和转译研究中的应用。洛杉矶猫队的领导， 和他们各自的机构提供了大量的资源，使发展局KCA能够扩大我们的 生物统计能力，增加更多的流行病学专业知识，并提供独特的生物信息学熟练程度 接近了。我们是洛杉矶猫科动物研究人员的综合DEB资源，我们提供了最多的 在洛杉矶猫中心内请求的服务。目标1.通过发展和扩大发展与合作伙伴关系，加强和扩大可持续发展基金 实施战略研究设计，强调严谨、可重复性、有效性和可持续性 调查结果。这将通过使用适当的控制和比较条件、减少偏差和 提高研究效率，然后部署最先进的数据分析、客观和 透明地解释研究结果，发布新发现，并寻求资金支持 我们研究工作的下一步。目标2.创建和实施新的统计分析、推论和 数据挖掘、精准医学和分子流行病学等领域的建模解决方案 传统的实验和观测研究，特别强调路易斯安那州的特殊队列。目标3. 通过为教师、实习生和 研究人员。因此，DEB KCA努力通过以下方式证明临床和转化性研究结论的合理性 在完善的基础设施内严格追求和客观解释调查结果 得出可持续的推论结论。

PROJECT SUMMARY: DESIGN, EPIDEMIOLOGY, AND BIOSTATISTICS CORE The overall goal of the Clinical Research Design, Epidemiology, and Biostatistics Key Component Activity (DEB KCA) of the Louisiana Clinical and Translational Science Center (LA CaTS) is to ensure that all clinical and translational research conducted within the LA CaTS purview meets the highest scientific standards for study design and analysis. During the initial funding period, we successfully leveraged existing DEB expertise from the faculties of the Primary Collaborating Institutions and implemented an integrated DEB support network that is now available to investigators at all participating LA CaTS institutions. We now provide DEB services and consultation to COBRE/INBRE mentees across the state, to our Roadmap and Meritorious scholars, and to other investigators seeking to expand their research toward translational efforts. To meet the needs for additional bioinformatics expertise, the DEB KCA director led the creation of the Southeast Informatics Consortium (SIC) to identify specific requirements, formulate ways to share resources and work together to advance the use of bioinformatics in clinical and translational research. The LA CATS leadership, and their respective institutions, provided considerable resources enabling the DEB KCA to expand our biostatistics capacity, add additional epidemiology expertise, and provide unique proficiency in bioinformatics approaches. We are a comprehensive DEB resource for LA CaTS investigators and we offer one of the most requested services within the LA CaTS Center. Aim 1. Enhance and expand the DEB KCA by developing and implementing strategic study designs, emphasizing rigor, reproducibility, validity, and sustainability of our findings. This will be accomplished using appropriate controls and comparison conditions, reducing bias, and increasing study power efficiency followed by deploying state-of-the-art data analyses, objective and transparent interpretation of research findings, publishing new discoveries, and seeking funding to support the next steps in our research pursuits. Aim 2. Create and implement novel statistical analytics, inferential and modeling solutions in data mining, precision medicine and molecular epidemiology in addition to more traditional experimental and observational research with strong emphasis on special Louisiana cohorts. Aim 3. Promote and deliver professional development by providing educational opportunities for faculty, trainees, and research staff. Thus, the DEB KCA strives to justify clinical and translational research conclusions through rigorous pursuit and objective interpretation of investigative findings within a well-established infrastructure for arriving at sustainable inferential conclusions.