Clinical Research Design, Epidemiology and Biostatistics Core

项目总结：设计、流行病学和生物统计学核心 临床研究设计、流行病学和生物统计学关键组成部分的总体目标 路易斯安那州临床和转化科学中心（LA CaTS）的活动（DEB KCA）旨在确保所有 在LA CaTS范围内进行的临床和转化研究符合最高的科学要求， 研究设计和分析的标准。在最初的融资期间，我们成功地利用了现有的 主要合作机构院系的DEB专业知识，并实施了综合DEB 支持网络，现在可供所有参与LA CaTS机构的研究者使用。我们现在提供 DEB服务和咨询COBRE/INBRE学员在整个国家，我们的路线图和功勋 学者和其他研究人员寻求扩大他们的研究对翻译的努力。满足 需要额外的生物信息学专业知识，DEB KCA主任领导创建了东南 信息学联盟（SIC）确定具体要求，制定共享资源和工作的方法 共同推进生物信息学在临床和转化研究中的应用。洛杉矶猫队的领导层， 以及他们各自的机构，提供了大量的资源，使DEB KCA能够扩大我们的 生物统计能力，增加额外的流行病学专业知识，并提供独特的生物信息学能力 接近。我们是一个全面的DEB资源洛杉矶猫调查员，我们提供了一个最 在洛杉矶CaTS中心内请求服务。目标1。通过开发和扩展DEB KCA， 实施战略研究设计，强调我们的研究的严谨性、可重复性、有效性和可持续性。 调查结果。这将使用适当的对照和比较条件来实现，减少偏倚， 通过部署最先进的数据分析、客观和 透明地解释研究结果，发表新发现，并寻求资金支持 我们研究的下一步目标二。创建和实施新颖的统计分析、推理和 数据挖掘、精准医学和分子流行病学等领域的建模解决方案 传统的实验性和观察性研究，重点是路易斯安那州的特殊人群。目标3。 通过为教师、学员和教师提供教育机会，促进和提供专业发展。 研究人员。因此，DEB KCA努力通过以下方式证明临床和转化研究结论的合理性： 在完善的基础设施内，严格追求和客观解释调查结果， 得出可持续的推论结论。

PROJECT SUMMARY: DESIGN, EPIDEMIOLOGY, AND BIOSTATISTICS CORE The overall goal of the Clinical Research Design, Epidemiology, and Biostatistics Key Component Activity (DEB KCA) of the Louisiana Clinical and Translational Science Center (LA CaTS) is to ensure that all clinical and translational research conducted within the LA CaTS purview meets the highest scientific standards for study design and analysis. During the initial funding period, we successfully leveraged existing DEB expertise from the faculties of the Primary Collaborating Institutions and implemented an integrated DEB support network that is now available to investigators at all participating LA CaTS institutions. We now provide DEB services and consultation to COBRE/INBRE mentees across the state, to our Roadmap and Meritorious scholars, and to other investigators seeking to expand their research toward translational efforts. To meet the needs for additional bioinformatics expertise, the DEB KCA director led the creation of the Southeast Informatics Consortium (SIC) to identify specific requirements, formulate ways to share resources and work together to advance the use of bioinformatics in clinical and translational research. The LA CATS leadership, and their respective institutions, provided considerable resources enabling the DEB KCA to expand our biostatistics capacity, add additional epidemiology expertise, and provide unique proficiency in bioinformatics approaches. We are a comprehensive DEB resource for LA CaTS investigators and we offer one of the most requested services within the LA CaTS Center. Aim 1. Enhance and expand the DEB KCA by developing and implementing strategic study designs, emphasizing rigor, reproducibility, validity, and sustainability of our findings. This will be accomplished using appropriate controls and comparison conditions, reducing bias, and increasing study power efficiency followed by deploying state-of-the-art data analyses, objective and transparent interpretation of research findings, publishing new discoveries, and seeking funding to support the next steps in our research pursuits. Aim 2. Create and implement novel statistical analytics, inferential and modeling solutions in data mining, precision medicine and molecular epidemiology in addition to more traditional experimental and observational research with strong emphasis on special Louisiana cohorts. Aim 3. Promote and deliver professional development by providing educational opportunities for faculty, trainees, and research staff. Thus, the DEB KCA strives to justify clinical and translational research conclusions through rigorous pursuit and objective interpretation of investigative findings within a well-established infrastructure for arriving at sustainable inferential conclusions.