Biocompatible Graphene Quantum Dots for Noninvasive Near-infrared Bioimaging
用于无创近红外生物成像的生物相容性石墨烯量子点
基本信息
- 批准号:10203022
- 负责人:
- 金额:$ 41.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse effectsAnimal ExperimentationAnimal ModelAnimal TestingAnimalsAreaBiologicalBiological AssayBiosensing TechniquesBiotechnologyCell SurvivalCellsChemicalsClinicalComplexContrast MediaDefectDevelopmentDiagnosisDiagnosticDrug Delivery SystemsDrug TransportExhibitsFluorescenceFluorescence MicroscopyFutureGlucosamineHealthHumanImageImage-Guided SurgeryIn SituIn VitroLightMagnetic Resonance ImagingMedical StudentsMicroscopicMinorMusNatural graphiteNear-infrared optical imagingOperative Surgical ProceduresOphthalmologyOpticsOrganOxidesOxygenPatientsPenetrationPharmaceutical PreparationsProcessPropertyQuantum DotsRare Earth MetalsResearchScienceSiteSliceStructureSystemTechniquesTestingTherapeuticTimeTissue imagingTissuesToxic effectUV Radiation ExposureVisible RadiationVisualizationWorkanimal imagingbasebioimagingbiomaterial compatibilitycareerdrug testingfeasibility testingfluorescence imagingfluorophorefunctional groupgrapheneimage guidedimage-guided drug deliveryimaging agentimaging platformin vivoin vivo imagingin vivo imaging systeminfrared microscopyluminescencemicrowave electromagnetic radiationmouse modelnanomaterialsnear infrared dyenoveloxidationozone exposurephysical propertyquantumreal-time imagessuccesstargeted treatmenttherapeutic evaluationtooltumorundergraduate studentuptakewater solubility
项目摘要
Project Summary/Abstract
Near-infrared (NIR) imaging is one of the most rapidly developing perspective techniques in
biomedical diagnostics enabling 10 - 100 times deeper tissue imaging than regular visible
fluorescence techniques. There is a significant clinical need for such imaging: high-depth CT and
MRI imaging strategies are complex and less suitable for low-depth biosensing and intraoperative
applications. Furthermore, in animal studies NIR imaging can enable in situ fluorescence tracking
of tested therapeutics or tumor visualization inside a living small animal. However, as NIR imaging
field is still developing, there is a lack of biocompatible and multifunctional platforms suitable for
imaging, sensing and even drug transport highly desired in animal studies.
In this project we will develop and test the feasibility of a novel NIR imaging platform based on
graphene quantum dots (GQDs) addressing the critical needs of NIR bioimaging: fluorescence in
the NIR (above 950 nm) with NIR excitation, high biocompatibility, photostability, and capabilities
for drug tracing and in vivo NIR imaging in live animal models. This will be implemented in 3 steps:
(1) synthesizing NIR-emissive GQDs via bottom-up and top-down approaches and characterizing
their optical and physical properties, (2) testing GQDs for NIR in vitro imaging and assessing their
biocompatibility and (3) performing in vivo imaging of GQD NIR fluorescence in live animals as well
as ex vivo organ tissue imaging quantifying GQD content in excised organs. We will concomitantly
assess potential adverse effects to select non-toxic GQD candidates. Throughout this process a variety
of synthesized GQD structures will undergo rigorous 3-step selection for the capabilities of (1) high
yield NIR fluorescence, (2) high biocompatibility and NIR imaging in cells, (3) NIR imaging inside a live
sedated animal with minimal/no toxicity. The selected GQD candidates will enable in vivo animal
testing of therapeutic delivery with noninvasive real-time image tracking reducing the number of
animals sacrificed. In a longer term, we expect these GQD platforms to become a basis of the
noninvasive NIR in vivo sensing in patients. As a result, the proposed initiative will address several
significant areas of biotechnology and its development will ultimately contribute to the
improvement of human health.
项目总结/文摘
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Detection of Pancreatic Cancer miRNA with Biocompatible Nitrogen-Doped Graphene Quantum Dots.
- DOI:10.3390/ma15165760
- 发表时间:2022-08-20
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Automated Approach to In Vitro Image-Guided Photothermal Therapy with Top-Down and Bottom-Up-Synthesized Graphene Quantum Dots.
- DOI:10.3390/nano13050805
- 发表时间:2023-02-22
- 期刊:
- 影响因子:0
- 作者:Lee B;Stokes GA;Valimukhametova A;Nguyen S;Gonzalez-Rodriguez R;Bhaloo A;Coffer J;Naumov AV
- 通讯作者:Naumov AV
Doped Graphene Quantum Dots as Biocompatible Radical Scavenging Agents.
- DOI:10.3390/antiox12081536
- 发表时间:2023-07-31
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Cancer Therapeutic siRNA Delivery and Imaging by Nitrogen- and Neodymium-Doped Graphene Quantum Dots.
- DOI:10.1021/acsbiomaterials.3c00369
- 发表时间:2023-05
- 期刊:
- 影响因子:5.8
- 作者:Alina Valimukhametova;B. Lee;U. C. Topkiran;Klara Gries;R. Gonzalez-Rodriguez;J. Coffer;G. Akkaraju;A. Naumov
- 通讯作者:Alina Valimukhametova;B. Lee;U. C. Topkiran;Klara Gries;R. Gonzalez-Rodriguez;J. Coffer;G. Akkaraju;A. Naumov
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Anton Naumov其他文献
Anton Naumov的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
- 批准号:
10591918 - 财政年份:2023
- 资助金额:
$ 41.01万 - 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
- 批准号:
23K15383 - 财政年份:2023
- 资助金额:
$ 41.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
- 批准号:
23H03556 - 财政年份:2023
- 资助金额:
$ 41.01万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
- 批准号:
23K17212 - 财政年份:2023
- 资助金额:
$ 41.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
- 批准号:
22H03519 - 财政年份:2022
- 资助金额:
$ 41.01万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
- 批准号:
563657-2021 - 财政年份:2022
- 资助金额:
$ 41.01万 - 项目类别:
Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 41.01万 - 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10671022 - 财政年份:2022
- 资助金额:
$ 41.01万 - 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
- 批准号:
10670918 - 财政年份:2022
- 资助金额:
$ 41.01万 - 项目类别:
Adverse Effects of Using Laser Diagnostics in High-Speed Compressible Flows
在高速可压缩流中使用激光诊断的不利影响
- 批准号:
RGPIN-2018-04753 - 财政年份:2022
- 资助金额:
$ 41.01万 - 项目类别:
Discovery Grants Program - Individual














{{item.name}}会员




