Clinical Core

临床核心

• 批准号: 10203770
• 负责人: Aimee Pierce
• 金额: $ 99.66万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10203770
• 关键词: African American; Aged, 80 and over; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Attention; Behavior monitoring; Biological; Biological Markers; Blood; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Collaborations; Communities; Computers; Conduct Clinical Trials; DNA; Data; Dementia; Development; Disease; Education; Elderly; Ensure; Environment; Fostering; Goals; Health; Home; Image; Individual; Infrastructure; Investigator-Initiated Research; Knowledge; Liquid substance; Magnetic Resonance Imaging; Measures; Methods; Monitor; Octogenarian; Oregon; Outcome; Participant; Peripheral; Pharmacology; Phase; Population; Positron-Emission Tomography; Procedures; Research; Research Activity; Research Design; Research Personnel; Research Subjects; Resources; Science; Scientist; Severity of illness; Sister; Sleep; Specimen; Standardization; Technology; Telemedicine; Testing; Time; Tissues; Training; Training and Education; Work; aging brain; aging in place; base; brain tissue; career; cohort; collaborative environment; community clinic; computer generated; cooperative study; data acquisition; data management; data sharing; dementia risk; digital; education research; follow-up; high risk; improved; innovation; interest; neuroimaging; neuroimaging marker; neuropathology; novel; outreach; pre-clinical; prevent; programs; recruit; remote monitoring; repository; sensor; statistics; tool; volunteer

Project Summary: Clinical Core The Clinical Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to ADRD; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Clinical Core is organized facilitate the study of transitions from normative function to preclinical and early Alzheimer’s disease (AD), as well as providing the core infrastructure to facilitate developing needed treatments to prevent or moderate these transitions across the spectrum of disease severity. It is additionally the responsibility of this core to provide the infrastructure for a wide array of innovative and evolving research activities ranging from providing clinical study design expertise (in concert with the Data Management and Statistics Core) to support of treatment studies. In being continually responsive to its research community, the Clinical Core has developed focused special units to further enhance the provision of leading edge imaging, telemedicine and clinical trials conduct. Within this context the Clinic Core Specific Aims are to: 1. Identify, recruit, and longitudinally assess individuals necessary to provide a ready pool of well- characterized subjects for research emphasizing the presymptomatic to early AD spectrum. 2. Include the underserved African American older adult population in this research enterprise through an on- going coordinated Satellite Program, the African American Dementia Aging & Project (AADAPt). 3. Coordinate and assist in concert with its sister Cores, tissue, biospecimen (blood, CSF, DNA), neuroimaging, and digital biomarker data acquisition to facilitate research incorporating new and developing tools and methods in such rapidly progressing fields as neuroimaging, biomarkers, remote monitoring, telemedicine, and clinical trials. 4. Support investigator-initiated research pertaining to the dementias and foster research collaboration and data sharing both regionally and nationally.

项目摘要：临床核心 临床核心是为了支持OADRC的5个总体目标的总体具体目标：1) 促进和支持AD和相关痴呆(ADRD)方面的创新研究和发现 支持丰富协作环境的组织基础设施；2)将资源集中到特定的 重点领域：临床前痴呆和疾病活动性，重点是年龄最大的老年人； 通过研究外周生物标志物、神经成像和在家中持续进行，捕捉到有意义的变化 行为监测；脑老化和老年痴呆的神经病理学；新治疗方法的新测试； 并改善有关痴呆症的教育和知识；3)通过以下方式提供材料支持科学 充分描述研究参与者、生物标本、脑组织、数据提供和分析；4) 为与可持续发展研究有关的国家研究共享领域作出贡献；以及5)提供场所和机制 对新科学家进行教育和培训，并对主要利益攸关方进行教育和告知。 OADRC的临床核心是促进从标准功能到临床前功能的过渡研究 和早期阿尔茨海默病(AD)，以及提供核心基础设施，以促进发展所需 在疾病严重程度的范围内预防或缓和这些转变的治疗。它是另外的 这个核心的责任是为一系列创新和不断发展的研究提供基础设施 活动范围从提供临床研究设计专业知识(与数据管理和 统计核心)，以支持治疗研究。在不断响应其研究社区的过程中， 临床核心开发了专门的单位，以进一步加强前沿成像的提供， 进行远程医疗和临床试验。在这一背景下，诊所核心的具体目标是： 1.确定、招募和纵向评估提供现成的油井资源所需的个人 以研究对象为特征，强调症状前到早期AD的谱系。 2.将未得到充分服务的非裔美国老年人口纳入这项研究计划-- 非裔美国人痴呆症老龄化与项目(AADAPt)。 3.与其姊妹核心、组织、生物制品(血液、脑脊液、DNA)协调和协助， 神经成像和数字生物标记物数据获取，以促进结合新的和 在诸如神经成像、生物标记物、远程 监测、远程医疗和临床试验。 4.支持研究人员发起的与痴呆症有关的研究，促进研究协作和 区域和国家之间的数据共享。