Clinical Core

临床核心

基本信息

  • 批准号:
    10369035
  • 负责人:
  • 金额:
    $ 105.24万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-01 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

Project Summary: Clinical Core The Clinical Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to ADRD; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Clinical Core is organized facilitate the study of transitions from normative function to preclinical and early Alzheimer’s disease (AD), as well as providing the core infrastructure to facilitate developing needed treatments to prevent or moderate these transitions across the spectrum of disease severity. It is additionally the responsibility of this core to provide the infrastructure for a wide array of innovative and evolving research activities ranging from providing clinical study design expertise (in concert with the Data Management and Statistics Core) to support of treatment studies. In being continually responsive to its research community, the Clinical Core has developed focused special units to further enhance the provision of leading edge imaging, telemedicine and clinical trials conduct. Within this context the Clinic Core Specific Aims are to: 1. Identify, recruit, and longitudinally assess individuals necessary to provide a ready pool of well- characterized subjects for research emphasizing the presymptomatic to early AD spectrum. 2. Include the underserved African American older adult population in this research enterprise through an on- going coordinated Satellite Program, the African American Dementia Aging & Project (AADAPt). 3. Coordinate and assist in concert with its sister Cores, tissue, biospecimen (blood, CSF, DNA), neuroimaging, and digital biomarker data acquisition to facilitate research incorporating new and developing tools and methods in such rapidly progressing fields as neuroimaging, biomarkers, remote monitoring, telemedicine, and clinical trials. 4. Support investigator-initiated research pertaining to the dementias and foster research collaboration and data sharing both regionally and nationally.
项目总结:临床核心 临床核心是一致的,以支持OADRC的5个首要目标的总体具体目标:1) 促进和维持AD和相关痴呆症(ADRD)的创新研究和发现, 组织基础设施支持丰富的协作环境; 2)将资源集中于特定的 重点领域:临床前痴呆和疾病活动,强调最古老的老年人; 通过外周生物标志物、神经影像学和连续居家研究捕获有意义的变化 行为监测;脑老化和老年痴呆症的神经病理学;新疗法的新测试; 改善有关痴呆症的教育和知识; 3)通过以下方式提供支持科学的材料: 特征鲜明的研究参与者、生物标本、脑组织、数据提供和分析; 4) 促进与ADRD相关的国家研究共享; 5)提供场地和机制, 教育和培训新的科学家,以及教育和告知主要利益攸关方。 OADRC的临床核心组织促进从规范功能到临床前的过渡研究 和早期阿尔茨海默病(AD),以及提供核心基础设施,以促进发展所需的 治疗以防止或缓和这些跨越疾病严重程度谱的转变。这是另外 这个核心的责任是为广泛的创新和不断发展的研究提供基础设施 活动范围包括提供临床研究设计专业知识(与数据管理和 统计核心),以支持治疗研究。在不断响应其研究界, 临床核心已经开发了重点特殊单位,以进一步加强提供前沿成像, 进行远程医疗和临床试验。在这种情况下,诊所的核心具体目标是: 1.确定、招募和纵向评估提供一个现成的良好的人才库所需的人员- 特征化的研究对象,强调症状前到早期AD谱。 2.包括服务不足的非洲裔美国老年人人口在这项研究企业通过一个对- 正在协调的卫星计划,非裔美国人痴呆症老龄化和项目(AADAPt)。 3.与其姐妹核心、组织、生物标本(血液、CSF、DNA)协调并协助, 神经成像和数字生物标志物数据采集,以促进研究, 在诸如神经成像、生物标志物、远程成像、神经成像和神经成像等快速发展的领域中开发工具和方法。 监测、远程医疗和临床试验。 4.支持由专家发起的有关痴呆症的研究,促进研究合作, 区域和国家数据共享。

项目成果

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Aimee Pierce其他文献

Aimee Pierce的其他文献

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{{ truncateString('Aimee Pierce', 18)}}的其他基金

Clinical Core
临床核心
  • 批准号:
    10641028
  • 财政年份:
    2020
  • 资助金额:
    $ 105.24万
  • 项目类别:
Clinical Core
临床核心
  • 批准号:
    10203770
  • 财政年份:
    2020
  • 资助金额:
    $ 105.24万
  • 项目类别:
Core E: Outreach, Recruitment & Education
核心 E:外展、招聘
  • 批准号:
    9053426
  • 财政年份:
  • 资助金额:
    $ 105.24万
  • 项目类别:
Core E: Outreach, Recruitment & Education
核心 E:外展、招聘
  • 批准号:
    8849260
  • 财政年份:
  • 资助金额:
    $ 105.24万
  • 项目类别:
Core E: Outreach, Recruitment & Education
核心 E:外展、招聘
  • 批准号:
    9256419
  • 财政年份:
  • 资助金额:
    $ 105.24万
  • 项目类别:
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