Neuroimaging Core

项目摘要：神经影像核心 俄勒冈州阿尔茨海默病研究中心（OADRC）有20多年的实质性纵向研究历史， 神经影像学研究，重点是健康老龄化，轻度认知障碍（MCI）和MRI标记物， 老年人早期痴呆症，并包括一个广泛的纵向数据库，超过3700 MRI的，从超过 1000名受试者，其中大多数年龄为80岁或以上。OADRC已经实施了先进的成像技术， 序列和分析技术，以进一步了解与年龄相关的MRI标记物， 认知和运动功能的变化，包括健康老龄化、早期认知衰退和成像标记物 血管疾病和白色物质的完整性。这些进步使OADRC能够合作， 促进脑老化的MRI研究在OHSU内外。OADRC神经影像核心 巩固了最古老的纵向神经成像的长期历史， 神经影像学的合作和创新。Neuroimaging Core支持体内3T MRI采集 和分析研究调查阿尔茨海默病和相关疾病的研究，并额外关注 血管性认知障碍和痴呆（VCID）。除了先进的体内MRI方案外， Neuroimaging Core开发了一种7T死后（PM）人脑组织成像协议， MRI定义的组织病理学感兴趣区域的靶向采样。支持的成像研究主题 核心将包括：1）健康老龄化和认知障碍的早期成像标志物，2） 脑血管疾病对认知功能和痴呆风险的影响，以及3）旨在 维持老年人的认知能力。神经影像学核心将提供必要的资源， 为当前和未来的衰老研究开发新的MRI序列和分析技术， 提高我们对与年龄相关的认知变化的理解。核心将继续巩固 并且基本上建立在包括体内和PM MRI方法的先前进展的基础上， 老年痴呆症风险人群中与认知能力下降相关的大脑变化的具体目标 拟议的神经影像学核心是： 1.获取并提供用于研究、最新技术水平、神经成像采集和高级 来自OADRC受试者的MRI处理，包括：健康对照、MCI、AD和其他 痴呆症， 2.获取并提供OADRC受试者的神经影像学数据用于研究， 3.促进涉及神经影像学的合作研究，并提高其他核心 资源 !

Project Summary: Neuroimaging Core The Oregon Alzheimer’s Disease Research Center (OADRC) has a 20+ year history of substantive longitudinal neuroimaging research, with a focus on healthy aging, mild cognitive impairment (MCI) and MRI markers of early dementia in the elderly, and includes an extensive longitudinal database of over 3700 MRI’s from over 1000 subjects, most of whom are 80 years of age, or older. The OADRC has implemented advanced imaging sequences and analysis techniques to further our understanding of MRI markers associated with age-related changes in cognitive and motor function, including healthy aging, early cognitive decline, and imaging markers of vascular disease and white matter integrity. These advances have allowed the OADRC to collaborate and foster MRI research in brain aging both within and outside of OHSU. The OADRC Neuroimaging Core consolidates the long-standing history of longitudinal neuroimaging of the oldest old, and more recent collaborations and innovations in neuroimaging. The Neuroimaging Core supports in vivo 3T MRI acquisition and analysis of studies investigating Alzheimer’s disease and related disorders, with an additional focus on vascular cognitive impairment and dementia (VCID). In addition to advanced in vivo MRI protocols, the Neuroimaging Core has developed a 7T post-mortem (PM) imaging protocol of human brain tissue for the targeted sampling of MRI-defined regions of interest for histopathology. Imaging research themes supported by the core will include: 1) healthy aging and early imaging markers of cognitive impairment, 2) the role of cerebrovascular disease on cognitive function and dementia risk, and 3) treatment and prevention trials aimed at maintaining cognition in the elderly. The Neuroimaging Core will provide essential resources to pursue and develop novel MRI sequence and analysis techniques for current and future aging studies and facilitate our ability to advance our understanding of age-related cognitive changes. The core will continue to consolidate and substantially build upon previous advances that include both in vivo and PM MRI methods to detect early brain changes associated with cognitive decline in elderly at risk for dementia. The Specific Aims of the proposed Neuroimaging Core are: 1. To obtain and make available for research, state of the art, neuroimaging acquisition and advanced MRI processing from OADRC subjects, including: healthy controls, MCI, and those with AD and other dementias, 2. To obtain and make available for research, neuroimaging data on OADRC subjects, and 3. To foster collaborative research involving neuroimaging, and enhance utilization of other core resources. !